This document discusses transdermal drug delivery systems (TDDS). It begins by defining TDDS as topically administered medicaments in the form of patches that deliver drugs systemically at predetermined rates. It then lists key advantages like avoidance of first-pass metabolism and improved compliance, as well as disadvantages like limitations on drug size and dose. The document proceeds to describe skin anatomy, permeation pathways, and factors affecting permeation. It outlines design components and classifications of TDDS. Evaluation methods including drug release and skin permeation studies are presented. Finally, examples of marketed TDDS products are provided.