The podcast discusses the four main types of macromolecules: carbohydrates, lipids, proteins, and nucleic acids. Each are polymers made up of carbon that are formed through condensation reactions and broken down through hydrolysis. Carbohydrates include monosaccharides, disaccharides, and polysaccharides. Lipids are hydrophobic and include fats, phospholipids, and steroids. Proteins have four levels of structure - primary, secondary, tertiary, and quaternary - and perform important functions. Nucleic acids, like DNA and RNA, are made up of nucleotides containing nitrogenous bases like cytosine, adenine, guanine, thymine, and uracil.