- Toxoplasma gondii is an apicomplexan parasite with a complex life cycle involving cats as the definitive host and intermediate hosts including nearly any mammal. Around one third of the world population is infected.
- While most infections are asymptomatic, it can cause serious illness in immunocompromised individuals or congenital infection passing from mother to fetus. Congenital infection poses risks of death or neurological and vision problems for the fetus.
- Diagnosis involves detecting antibodies, antigens, parasite DNA, or the parasite itself microscopically in tissues or body fluids. Treatment depends on the patient's immune status and includes pyrimethamine with sulfonamides for serious infections.
Zoonotic parasite; Toxoplasma is an opportunistic pathogen.
Infects animals, cattle, birds, rodents, pigs, and sheep.
and humans.
Causes the disease Toxoplasmosis
coccidian parasite is a very important topic for pg entrance........so every important point about it have been discussed in detail......take a look at it...
Zoonotic parasite; Toxoplasma is an opportunistic pathogen.
Infects animals, cattle, birds, rodents, pigs, and sheep.
and humans.
Causes the disease Toxoplasmosis
coccidian parasite is a very important topic for pg entrance........so every important point about it have been discussed in detail......take a look at it...
Everything you wanna know about Chagas disease and Trypanosoma cruzi in a nutshell, including the morphology and life-cycle of the parasite ,diagnosis treatment and prophylaxis of Chagas disease.
Toxoplasma Gondii.
Toxoplasmosis - Congenital Toxoplasmosis
The transition between tachyzoites and bradyzoites.
T.gondii as an Epigenator.
Immune Response Pathway.
Behavior Changer by T.gondii infection.
Echinococcus granulosus, also called hydatid worm belongs to class Cestoda
It causes cystic echinococcosis in livestock and humans being intermediate hosts and parasitize the small intestines of adult canids
It is a zoonotic disease
Definitive hosts are carnivorous predators like dogs, wolves, foxes and lions. While sheep, goat, cattle, pigs and rodents are intermediate hosts. Birds and arthropods act as mechanical vectors
Everything you wanna know about Chagas disease and Trypanosoma cruzi in a nutshell, including the morphology and life-cycle of the parasite ,diagnosis treatment and prophylaxis of Chagas disease.
Toxoplasma Gondii.
Toxoplasmosis - Congenital Toxoplasmosis
The transition between tachyzoites and bradyzoites.
T.gondii as an Epigenator.
Immune Response Pathway.
Behavior Changer by T.gondii infection.
Echinococcus granulosus, also called hydatid worm belongs to class Cestoda
It causes cystic echinococcosis in livestock and humans being intermediate hosts and parasitize the small intestines of adult canids
It is a zoonotic disease
Definitive hosts are carnivorous predators like dogs, wolves, foxes and lions. While sheep, goat, cattle, pigs and rodents are intermediate hosts. Birds and arthropods act as mechanical vectors
Toxoplasma gondii es una especie de protozoo parásito causante de la toxoplasmosis.
Enfermedad causada por protozoos que se presenta en diversos mamíferos, aves y reptiles y puede contagiarse al ser humano por contacto con animales afectados, especialmente gatos, o por el consumo de verduras contaminadas con las deyecciones de estos.
Este mal puede afectar a mujeres embarazadas y causar daños neurológicos y de otro tipo en el feto; es contagiada principalmente por un parásito hospedado en los gatos o en la carne cruda contaminada.
Putting the Cat in the Catalogue: A Feline-Inspired OPAC Theme For KohaGalen Charlton
Lightning talk at the Code4Lib British Columbia meeting on 27 November 2014, presenting a jQuery plugin for adding unAPI visibility (and cats!) to library catalogs.
تقديم شيتات وعملي مادة الباطنة لطلاب الفرقة السادسة بكلية الطب ليسهل عليهم التواصل مع المرضى وفهم الجانب العملي بشكل مبسط وكذلك لعمل خرائط ذهنية عن النقاط الاساسية في فحص المريض
Torch infections during pregnancy by dr alka mukherjee nagpur ms indiaalka mukherjee
TORCH Syndrome refers to infection of a developing fetus or newborn by any of a group of infectious agents. "TORCH" is an acronym meaning (T)oxoplasmosis, (O)ther Agents, (R)ubella (also known as German Measles), (C)ytomegalovirus, and (H)erpes Simplex. Infection with any of these agents (i.e., Toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex viruses) may cause a constellation of similar symptoms in affected newborns. These may include fever; difficulties feeding; small areas of bleeding under the skin, causing the appearance of small reddish or purplish spots; enlargement of the liver and spleen (hepatosplenomegaly); yellowish discoloration of the skin, whites of the eyes, and mucous membranes (jaundice); hearing impairment; abnormalities of the eyes; and/or other symptoms and findings. Each infectious agent may also result in additional abnormalities that may be variable, depending upon a number of factors (e.g., stage of fetal development
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
6. • Acute disease in adults:
• the majority are asymptomatic
or unrecognized.
Clinical Importance
7. • Immunocompromised Patients:
• Most frequently results from reactivation of latent
infection
• it can cause serious pathology including:
hepatitis, pneumonia, blindness, myocarditis
• the central nervous system is primarily involved
with diffuse encephalopathy, meningoencephalitis
or cerebral mass lesions. Toxoplasma encephalitis
has been reported as a life-threatening among
patients with AIDS.
Clinical Importance
8. • Congenital Toxoplasmosis:
• Total maternal-fetal transmission is about 30% throughout all of
gestation, but varies from 6% at 13 weeks to 72% at 36 weeks
• If the fetus is exposed during the first trimester, death nearly
always occurs as a result of CNS damage.
• Infection during the second trimester may result in hydrocephaly,
blindness, or other nervous system damage.
• Later infection may result in blindness or mild CNS defects.
• However, women who are exposed to this parasite before
pregnancy do not transmit the infection to the fetus.
Clinical Importance
9.
10. - Ocular disease (toxoplasmic retinochoroiditis)
• the most common sequelae of congenital
toxoplasmosis
• up to 2% of adults newly infected with T. gondii
develop ocular lesions
Clinical Importance
13. Tachyzoites vs bradyzoites
Tachyzoites
rapidly dividing stage
seen in body fluids in early,
acute infection
directly destroy cells,
particularly parenchymal
and reticuloendothelial cells
Bradyzoites
slowly dividing stage
contained in cysts in muscle
and brain tissue and in the eye
Released from ruptured tissue
cysts cause local inflammation
with blockage of blood vessels
and necrosis
14.
15. Life cycle
sexual asexual
• Intestinal
(enteroepithelial)
phases
• occurs in cats only (wild
as well as domesticated
cats)
• produces "oocysts."
• Extraintestinal phases
• occurs in all infected
animals (including cats)
• produces "tachyzoites"
and,eventually,"bradyzi
tes“ or "zoitocysts."
16.
17. Prevention measuresAction situation
Wash hands carefully after stroking a cat
Wear gloves when changing cat litter
Change litter frequently and wash the tray with hot water (> 60° C)
Avoid litter in the kitchen
Cat contact
Cook the meat well-done or stew
Avoid microwave cooking for meat
Avoid raw vegetables at restaurants
Avoid raw shellfish
Avoid raw goat milk
Meals
Wash vegetables, fruits and herbs thoroughly, especially if they grow
close to the ground
Wash hands, knives, any containers and table thoroughly after meat
manipulation or cutting
Preparation of
meals
Prefer mineral water to tap waterWater
Wash hands thoroughly and brush nails after any outdoor activities in
contact with soil
Wear gloves for gardening
Avoid ingestion of water during recreation activities in lakes or rivers
Gardening or
outdoor activities
Prevention of Toxoplasma infection
18. control
• It is difficult to control toxoplasmosis because of wide range
of animal reservoirs.
• Currently, there is no effective vaccine available for humans.
• A genetically engineered vaccine is under development for
use in cats.
19.
20. Microscopy
• Tachyzoites and tissue cysts can be detected
• Specimens: blood, sputum, bone marrow aspirate,
cerebrospinal fluid (CSF), aminiotic fluid, and biopsy
material from lymphnode, spleen, and brain.
Smear made from above specimens is stained by: Giemsa,
PAS, or Gomori methanamine silver (GMS) stain
Tachyzoites or cyst can also be demonstrated effectively by
fluroscent conjugated antibody technique in tissue biopsy
or impression smear.
Presence of only tissue cysts does not differentiate
between active and chronic infection.
The presence of cysts in placenta or tissues of newborn
establishes congenital toxoplasma infection.
21. Serodiagnosis
Antibody detection
Diagnosis of acute infection with T. gondii can be made by detection of the
simultaneous presence of IgM and IgG antibodies.
Tests for detecting IgG antibody include:
o Enzyme-linked immunosorbent assay (ELISA)
o Indirect fluorescent antibody test (IFAT)
o Latex agglutination test
o Sabin-Feldman dye test.
Positive IgG can be detected as early as 2–3 weeks after infection.
Peak level of antibody is observed in blood 4–8 weeks after infection.
Positive IgM antibody titer indicates an early primary infection. The serum IgM
titer can be measured by:
o sandwich IgM ELISA
o IgM immunosorbent assay (IgM-ISAGA).
Both assays are equally specific and sensitive.
Negative IgM titer and positive IgG titer indicate distant infection.
Sandwich IgA-ELISA test is used for detecting congenital infection in newborns.
22. Serodiagnosis
Antigen detection
Detection of antigen by ELISA indicates recent
Toxoplasma infection.
In AIDS and other immunocompromised
patients, antigen detection is very useful.
Detection of antigen in amniotic fluid is helpful
to diagnose congenital toxoplasmosis.
23. Molecular Methods
• DNA hybridization techniques and polymerase
chain reaction (PCR) are increasingly used to
detect Toxoplasma from different tissues and body
fluids.
B1 gene of T. gondii can be detected by PCR of the
amniotic fluid in case of congenital toxoplasmosis
24. Imaging
• Magnetic resonance imaging (MRI) and
computed tomography (CT) scan are used to
diagnose toxoplasmosis with central nervous
system involvement.
Ultrasonography (USG) of the fetus in utero at
20–24 weeks of pregnancy is useful for
diagnosis of congenital toxoplasmosis.
25. Animal Inoculation
• Toxoplasma can be isolated by
inoculating body fluids, blood, or
tissue specimens by intraperitoneal
inoculation in mice or in tissue culture.
• Mice should be examined for
Toxoplasma in their peritoneal
exudate after 7–10 days of inoculation.
26. Skin test of Frenkel
• Diluted toxoplasmin is injected intradermally and
delayed positive reaction appears after 48 hours.
• This test is not very reliable for diagnosis
27. Treatment
Congenital Toxoplasmosis:
• Oral pyrimethamine (1 mg/kg) daily and sulfadiazine (100 mg/ kg) with folinic
acid for 1 year. Systemic corticostoriod may be added to reduce chorioretinitis.
Immunocompetent Patients
who have only lymphadenopathy, do not require specific therapy unless they have
persistent, severe symptoms.
• Patients with ocular toxoplasmosis are treated for 1 month with pyrimethamine
plus either sulfadiazine or clindamycin
Immunocompromised Patients
AIDS patients who are seropositive for T. gondii and have a CD4+ Tlymphocyte
count below <100/μL, should receive primary prophylaxis against toxoplasma
encephalitis.
Trimethoprimsulfamethoxazole is the drug of choice. If
trimethoprimsulfamethoxazole cannot be tolerated by patients,
dapsonepyrimethamine is the recommended alternative drug of choice.
Prophylaxis against toxoplasma encephalitis should be discontionued in patients
who have responded to antiretroviral therapy (ART) and whose CD4+ T
lymphocyte count has been above 200/μL for 3 months.
28. References
MEDICAL AND CLINICAL LABORATORY PROFESSIONALS- John
W. Ridley, Ph.D.
DIAGNOSING MEDICAL PARASITES- A Public Health Officers
Guide to Assisting Laboratory and Medical Officers
MICROBIOLOGY DEMYSTIFIED- TOM BETSY, D.C.JIM KEOGH
Lippincott’s Illustrated Reviews: Microbiology Third Edition
Chapter 14 Toxoplasmosis: A Widespread Zoonosis Diversely
Affecting Humans and Animals-Florence Robert-Gangneux,
Dominique Aubert and Isabelle Villena
Paniker’s Textbook of Medical Parasitology-SEVEnth EDition
Apicomplexans have an apical complex of organelles that form an apex (tip).
This tip contains enzymes that enable it to penetrate the tissues of a host.
- It was found in the African rodent Ctenodactylus gondi which supplied the parasite species name
- The Genus name derived fron the Greek toxon, bow
Toxoplasma gondii has very low host specificity, and it will probably infect almost any mammal. It has also been reported from birds, and has been found in virtually every country of the world
Toxoplasmosis in the Middle East and North Africa
The most common recognized finding is cervical adenopathy usually painless accompanied with low grade fever
the other common presentation is mononucleosis-like syndrome
mononucleosis-like syndrome: characterized by fever headache malaise lymphoadenopathy hepatosplenomegaly myalgia and atypical lymhocytosis
-the symptomatic illness may persist for months
malignancies, organ transplants, leukemias and
patients with acquired immune deficiency syndrome (AIDS).
-the incedince of Reactivation of latent infection in AIDS is 30%
pulmonary
Although it can affect all organ systems, there is a remarkable predominance of toxoplasma encephalitis
Hydrocephalus is the least common but most dramatic result of toxoplasmosis
Elevated pale cotton like patches in the retina
Morphology varies during the developmental cycle
: There are two kinds of Toxoplasma trophozoites found in human infections:
. Tachyzoites, bradyzoites
includes two phases
1-Unsporulated oocysts are shed in the cat’s feces . Oocysts take 1-5 days to sporulate in the environment and become infective.
2- Intermediate hosts become infected after ingesting soil, water or plant material contaminated with sporulated oocysts
3-Oocysts transform into tachyzoites shortly after ingestion These tachyzoites localize in neural and muscle tissue and develop into tissue cyst bradyzoites
4- Cats become infected after consuming intermediate hosts harboring tissue cysts or directly by ingestion of sporulated oocysts.
5- Humans can become infected by any of several routes: eating undercooked meat of animals harboring tissue cysts
7- consuming food or water contaminated with cat feces or by contaminated environmental samples (such as fecal-contaminated soil or changing the litter box of a pet cat)
8-transplacentally from mother to fetus
9 In the human host, the parasites form tissue cysts; these cysts may remain throughout the life of the host
Serology is the main stay for diagnosis of toxoplasmosis