This presentation discusses the launch of Tibone® tablet by Masum Chowdhury. Some key points:
- Tibone® (tibolone) is a tissue-specific hormone replacement therapy for menopausal symptoms like hot flashes and osteoporosis.
- The presentation outlines Tibone®'s efficacy, safety profile, and effects on mood, sexuality, bones, cardiovascular system and more based on clinical experience.
- An action plan is proposed to position Tibone® as the first choice for menopausal symptom management and increase its prescription share over competitors like Livial and Uvilon.
ATOSIBAN Update In Preterm Labor Dr. Sharda Jain Lifecare Centre
PRETERM BIRTH
As defined by the WHO,
Preterm is defined as babies born alive before 37 weeks of
pregnancy are completed.
Sub-categories of preterm birth:
Extremely preterm (<28><32><34><37 weeks).
Ovulation induction protocols for unexplained infertility new advances 2019 f...Anu Test Tube Baby Centre
What are the new advances in assisted reproductive technologies with respect to ovulation induction for unexplained infertility ? - Intra uterine insemination (IUI) and in vitro fertilization (IVF)
Luteal phase insufficiency is one of the most important aspect of fertility treatment . But due to lack of proper understanding many unwanted medications are prescribed . This ppt will give an idea on the best evidence based luteal phase support for an ivf cycle.
Role of progesterone in rpl by dr alka mukherjee dr apurva mukherjeealka mukherjee
It is well known that progesterone plays a major role in the maintenance of pregnancy, particularly during the early stages, as it is responsible for preparing the endometrium for implantation and maintenance of the gestational sac. The management of pregnant women at risk of a threatened or idiopathic recurrent miscarriage is complex and critical.
Early pregnancy loss, also known as miscarriage, generally occurs in the first trimester. For some women and their partners, miscarriages can happen several times, also known as recurrent miscarriages. While there are sometimes causes for miscarriages that are found, often no clear reasons can be found. The hormone called progesterone prepares the womb (uterus) to receive and support the newly fertilized egg during the early part of pregnancy. It has been suggested that some women who miscarry may not make enough progesterone in the early part of pregnancy. Supplementing these women with medications that act like progesterone (these are called progestogens) has been suggested as a possible way to prevent recurrent miscarriage.
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
ATOSIBAN Update In Preterm Labor Dr. Sharda Jain Lifecare Centre
PRETERM BIRTH
As defined by the WHO,
Preterm is defined as babies born alive before 37 weeks of
pregnancy are completed.
Sub-categories of preterm birth:
Extremely preterm (<28><32><34><37 weeks).
Ovulation induction protocols for unexplained infertility new advances 2019 f...Anu Test Tube Baby Centre
What are the new advances in assisted reproductive technologies with respect to ovulation induction for unexplained infertility ? - Intra uterine insemination (IUI) and in vitro fertilization (IVF)
Luteal phase insufficiency is one of the most important aspect of fertility treatment . But due to lack of proper understanding many unwanted medications are prescribed . This ppt will give an idea on the best evidence based luteal phase support for an ivf cycle.
Role of progesterone in rpl by dr alka mukherjee dr apurva mukherjeealka mukherjee
It is well known that progesterone plays a major role in the maintenance of pregnancy, particularly during the early stages, as it is responsible for preparing the endometrium for implantation and maintenance of the gestational sac. The management of pregnant women at risk of a threatened or idiopathic recurrent miscarriage is complex and critical.
Early pregnancy loss, also known as miscarriage, generally occurs in the first trimester. For some women and their partners, miscarriages can happen several times, also known as recurrent miscarriages. While there are sometimes causes for miscarriages that are found, often no clear reasons can be found. The hormone called progesterone prepares the womb (uterus) to receive and support the newly fertilized egg during the early part of pregnancy. It has been suggested that some women who miscarry may not make enough progesterone in the early part of pregnancy. Supplementing these women with medications that act like progesterone (these are called progestogens) has been suggested as a possible way to prevent recurrent miscarriage.
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
Understanding your-menstrual-cycle and body systemRufus Yamoah
This Slide Show Presentation is Pastor Derashay Zorn for LADY CARE COACHING. Learn how to manage your body and take care of yourself as a lady during menstrual cycle.
Tibolone 2.5mg tablets pil, taj pharmaceuticals.Taj Pharma
Tibolone 2.5mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tibolone Dosage & Rx Info | Tibolone Uses, Side Effects , Tibolone 2.5mg Tablets: Indications, Side Effects, Warnings, Tibolone - Drug Information - Taj Pharma, Tibolone dose Taj pharmaceuticals Tibolone interactions, Taj Pharmaceutical Tibolone contraindications, Tibolone price, Tibolone , Taj Pharma Tibolone 2.5mg Tablets - Taj Pharma . Stay connected to all updated on Tibolone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Menopause is a biological stage in a woman's life that occurs when she stops menstruating and reaches the end of her natural reproductive life. This is not usually abrupt, but a gradual process during which women experience perimenopause before reaching post-menopause”
Fibromyalgia and its management by cupping therapynium
Cupping therapy is especially beneficial for people suffering from fibromyalgia. If you have fibromyalgia, you know how tender your muscles and joints are. Even a vigorous massage can send your body into spasm. Cupping, however, is a non-irritating type of treatment. It will not exacerbate your muscle pain in anyway, or compound any of your fibromyalgia symptoms...
কোভিড-১৯ সংক্রমনের সময় কীভাবে আপনি নিরাপদে রোজা রাখবেন। ইসলামিক সেন্টার ফর আয়ারল্যান্ড এর নীতিমালা শুধুমাত্র কোভিড-১৯ সংক্রান্ত পরিস্থিতির জন্য তৈরি করা হয়েছে।
Safe Ramadan Practices in the Context of the COVID-19 (WHO-COVID-19-Ramadan-2...Mohammad Masum Chowdhury
কোভিড-১৯ সংক্রমনের সময় কীভাবে আপনি নিরাপদে রোজা রাখবেন। ওয়াল্ড হেলথ্ অর্গানাইজেশন এর নীতিমালা শুধুমাত্র কোভিড-১৯ সংক্রান্ত পরিস্থিতির জন্য তৈরি করা হয়েছে।
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. Launching Tibone® Tablet By MD.
Masum Chowdhury 1
Launching Presentation
on Tibone® (Tibolone)
The Tissue-Specific effects
of Tibone® (tibolone)
Presented By:
Masum Chowdhury
Product Officer
Techno Drugs
2. This presentation was prepared in
the year 2005.
At that time I was a Product Officer
at Techno Drugs Ltd.
Launching Tibone® Tablet By MD.
Masum Chowdhury 2
3. Launching Tibone® Tablet By MD.
Masum Chowdhury 3
OUR CUSTOMERS IN THE
NEW AGE
• More Educated
• Wants to enjoy life in any age
• Aware of Competitive Product
(Livial, Uvilon)
• Aware about the adverse effects
of Conventional HRT
• Sensitive to Health and Social
issues
• Aware of Global Trand
4. • Choosing and tracking
appropriate customers for
Tibone
• Positioning your offering
• Interacting with those
customers who are Prescribe
and use Tibone
• Controlling the marketing
effort
• Continuity of performance
6. Launching Tibone® Tablet By MD.
Masum Chowdhury 6
Problems of Menopause
Vasomotor symptoms
Urogenital problems
Psychogenic problems
Osteoporosis
Coronary heart disease
Other problems
7. Launching Tibone® Tablet By MD.
Masum Chowdhury 7
VASOMOTOR SYMPTOM
Most women who seek medical
attention for menopausal symptoms
complain of vasomotor symptoms.
Hot Flashes or Flushes
Night Sweat
Hot Flushes: This is experienced
by about 65-85% of women for about
1-2 years in her Climacteric period
8. Launching Tibone® Tablet By MD.
Masum Chowdhury 8
Somatotrophic symptoms
These include: atrophic-inflammatory
changes of the vulva, vagina, bladder,
and urethra (urogenital atrophy),
atrophy of the skin and the breasts,
pruritus, pain on sexual intercourse,
urinary incontinence, dysuria (painful
urination).
9. Constilation of Symptoms
Preceded by an aura
Finger temperature raises about 6
degrees
Pulse rate increases about 10
beats
It is usually transient, but may last
upto 30 minutes. It is the major
cause of insomnia.
10. Launching Tibone® Tablet By MD.
Masum Chowdhury 10
Urogenital Problems
Vaginitis: Results from atrophy of the genital
epithelium.
Symptoms include:-
• Irritation
• Burning
• Pruritus
• Leucorrhoea
11. Launching Tibone® Tablet By MD.
Masum Chowdhury 11
Due to the vaginal mucosal changes.
Symptoms include:-
• Dyspaerunia
• Vaginitis
• Vaginismus
• Physical discomfort
• Loss of sexual interest
Sexual Dysfunctions
12. Launching Tibone® Tablet By MD.
Masum Chowdhury 12
Due to atrophy of lower urinary tract
mucosa
Symptoms include:-
• Dysuria
• Cystitis
• Urethral caruncles
• Urethritis
Urinary Dysfunction
14. Launching Tibone® Tablet By MD.
Masum Chowdhury 14
Osteoporosis
Exaggereted bone mass loss particularly
trabecular bone leads to disabilities, like
Back pain
Decreased height
Decreased mobility
Increased risk of fracture of
Vertebral body (spinal compression)
Hip bones
Ribs, Humerus, etc.
15. Launching Tibone® Tablet By MD.
Masum Chowdhury 15
Coronary Heart Disease
Incidence of
Cononary Heart disease (CHD),
Congestive Heart Failure (CHF),
Atherosclerotic Cardiovascular
Disease (ACD)
Are significantly lower in
premenopausal women than men, but
after menopause rise above those for
men.
Oestrogens level is the prime factor
that makes the difference.
16. Launching Tibone® Tablet By MD.
Masum Chowdhury 16
Other Problems
Marked thinning and wrinkling of skin
Loss of axillary and pubic hairs
Mild Hirsutism
Atrophy of Breast
Intraumbilical obesity due to fat
mobilization
Low HDL-Cholesterol and High LDL-
Cholesterol
17. Launching Tibone® Tablet By MD.
Masum Chowdhury 17
Metabolic Symptoms
In addition, metabolic changes may
also take place: a tendency to gain
weight, osteoporosis, rise in lipids
(blood fats), rheumatic changes, and
a tendency to gout.
18. Surgical Menopause occurs when ovaries
removed, usually during a hysterectomy
(removal of the uterus). Hysterectomy is the
second most common major surgical
procedure among reproductive-aged women.
Hormone therapy is the most effective FDA-
approved medicine for these menopausal
symptoms.
Why Surgical Menopause
Occurs
19. Launching Tibone® Tablet By MD.
Masum Chowdhury 19
Typical symptoms of Surgical Menopause
Hot flashes — flushing with a sensation of heat that
may include sweating often accompanied by an
increased pulse rate, palpitations, and sometimes
followed by chills
•Night sweats — hot flashes with drenching
perspiration occurring at night
Vaginal dryness — associated with itching, burning,
and irritation; sexual intercourse may also be more
difficult, or even painful. If you are experiencing only
vaginal symptoms
20. Launching Tibone® Tablet By MD.
Masum Chowdhury 20
What is Tibolone
• Tibolone is tissue specific hormone
replacement therapy. Tibolone’s
tissue specific activity may be
explained by the interplay of
several mechanisms,
21. Launching Tibone® Tablet By MD.
Masum Chowdhury 21
What is Tibolone
• Such as
– Metabolic Conversion of tibolone to
compounds with different biological
activity.
– Classical interaction with steroid
receptor.
– Specific local metabolism within the
target tissue.
22. Launching Tibone® Tablet By MD.
Masum Chowdhury 22
Tibone® (Tibolone):
Clinical Experience
•Efficacy
•Climacteric Complaints
•Mood and sexual well-being
•Urogenital System
•Bone
•Safety
•Endometrium
•Breast
•Cardiovascular System
24. Launching Tibone® Tablet By MD.
Masum Chowdhury 24
Tibone and climacteric
complaints
•Climacteric complaints are common
and affect quality of life and well-being
•Tibone is as effective as conventional
HRT in relieving hot flushes and
sweating
25. Launching Tibone® Tablet By MD.
Masum Chowdhury 25
Tibone: Effects on mood and sexual
well-being
•Tibone improves mood and libido in
postmenopausal women
•Tibone has a beneficial effect on sexual well-
being by increasing sexual desire, frequency
of arousability, sexual fantasies and vaginal
lubrication
•Tibone also produces significant
improvement in sexual enjoyment compared
with conventional HRT with regard to coital
frequency and satisfaction
26. Launching Tibone® Tablet By MD.
Masum Chowdhury 26
Tibone and the urogenital
system
• Gives Oestrogenic effect on
vagina
•Improves vaginal atrophy and
urogenital symptoms
27. Launching Tibone® Tablet By MD.
Masum Chowdhury 27
The effects of Tibone on bone
•Tibone increases bone mineral
density by reducing bone turnover
and prevents osteoporosis in a
similar manner to Oestrogens
28. Launching Tibone® Tablet By MD.
Masum Chowdhury 28
The effects of Tibone
•Tibone closely matches the ideal product
profile treatment of prevention of bone loss in
postmenopausal women
29. Launching Tibone® Tablet By MD.
Masum Chowdhury 29
Tibone: Tolerability
•Tibone has a different effect on
breast tissue compared with
conventional HRT; the incidence of
breast tenderness is lower
•Tibone shows a high amenorrhoea
rate and significantly less irregular
bleeding than seen with
conventional HRT
31. Launching Tibone® Tablet By MD.
Masum Chowdhury 31
Tibone and the endometrium
•Endometrium
•Tissue-Specific endometrial
conversion into D4-metabolite
•Progestogenic dominant effect on
the endometrium
•No endometrial stimulation
•No withdrawal bleeds
32. Launching Tibone® Tablet By MD.
Masum Chowdhury 32
Breast safety HRT and diagnosis of
breast cancer
•Mammography is the best
diagnostic test in women over 50
•HRT can induce mammographic
changes
33. Launching Tibone® Tablet By MD.
Masum Chowdhury 33
Tibone and the breast Conclusions
•Tibolone is a tissue-specific steroid with Oestrogenic,
progestogenic and androgenic activity
•In vitro studies show that Tibolone inhibits the
production of estradiol in breast cells.
•Tibone has an effect on the breast that is different from
that of Oestrogens
34. Launching Tibone® Tablet By MD.
Masum Chowdhury 34
How does Tibone works
Tibolone
Active Metabolites
3 - OH-Tibolone D 4 - Isomer
Oestrogenic receptors Progesterone receptors Androgenic Receptors
Bone: Decreases bone turnover
Improves bone density
Vagina: Improves vaginal
dryness
Reduce Dyspaerunia
Brain: Improves libido
Increase Sexual well- being
CVS: Stimulation cardiac output,
blood flow, vessel relaxation.
Reduce serum HDL
Endometrium:
No endometrial
proliferation
3 α - OH-Tibolone
35. Launching Tibone® Tablet By MD.
Masum Chowdhury 35
Tibone and the Cardiovascular System
•Stimulates cardiac output, blood flow, vessel
relaxation.
•Stimulates fibrinolysis, no effect on
coagulation
•Decreases total cholesterol, triglycerides and
lipoprotein(a)
•Animal studies suggest a strong anti-
atherosclerotic effect
•To date, there is no evidence of an increase in
CHD risk
36. Launching Tibone® Tablet By MD.
Masum Chowdhury 36
Tibone : Efficacy
•Efficacy
•Tibone is as effective as conventional HRT in relieving
hot flushes
•Tibone enhances mood and libido in postmenopausal
women
•Tibone has a beneficial effect on sexual well-being by
increasing sexual desire, vaginal lubrication and by
improving sexual enjoyment
•Tibone treats vaginal atrophy and improves urogenital
symptoms
•Tibone is as effective as conventional HRT in preventing
bone loss in postmenopausal women
•Tibone increases bone density in osteoporotic women
37. Launching Tibone® Tablet By MD.
Masum Chowdhury 37
Tibone: Clinical Experience
•Tolerability
•Tibone has a different effect on breast
tissue compared with conventional HRT;
the incidence of breast tenderness is
lower
•Tibone shows a significantly less
irregular bleeding than seen with
conventional HRT
38. Launching Tibone® Tablet By MD.
Masum Chowdhury 38
Tibone: Safety Profile
•Tolerability
•Tibone does not stimulate the
endometrium
•Tibone shows no stimulation of the
breast and no increase in mammographic
density has been observed
•Tibone has beneficial effects on several
cardiovascular parameters
•
39. Launching Tibone® Tablet By MD.
Masum Chowdhury 39
Action Plan
Tibone ®
• Tibone ®
(Tibolone lNN 2.5 mg) Tablet for oral
administration.
40. Launching Tibone® Tablet By MD.
Masum Chowdhury 40
Tibone ®
• Presentations: It is a white tablet.
Tibone (Tibolone lNN 2.5 mg)
• Dosage Form: Tablet
• Routes of Administrations: Oral
41. Launching Tibone® Tablet By MD.
Masum Chowdhury 41
Objectives
• 1. First you should need to know that our
vision is to enter new horizon. We are
optimistic to our Tibone® .
• 2. Establish Techno Products Tibone® as the
1st Choice in Menopausal symptoms
management.
• 3. Prescription is prestige. So you convince at
least 5 Gynaecologists or more at your territory
to prescribe our Tibone®
42. Launching Tibone® Tablet By MD.
Masum Chowdhury 42
Objectives
• 1. Take extra care on Tibone® for steady
growth of those presentations in every month
• 2. Try to increases 100% prescription share
and sales of Tibone® from General
Physicians, Medicine Doctors, Gynaecologists,
Orthopaedic Doctors and Endocrinologists etc.
• 3. To achieve the individual territorial target of
Tibone® Tablet in the month of
September’05 from the rural market and urban
market.
• 4. Highlight the product benefits to the Doctors.
43. Launching Tibone® Tablet By MD.
Masum Chowdhury 43
Target Doctors
• Medicine Doctors,
• Gynecologists (specially lady Gynecologists)
• Endocrinologists
• Orthopaeditricians
• General Physicians
44. Launching Tibone® Tablet By MD.
Masum Chowdhury 44
Positioning
• Tibone ® is the world famous hormone
replacement therapy for menopausal women.
• Tibone ® is the Drug of choice for
Menopausal symptoms such as
• 1. Vasomotor symptoms
• 2. Osteoporosis
• 3. Urogenital problems
• 4. Psychogenic problems
• 5. Coronary heart diseases etc.
45. Launching Tibone® Tablet By MD.
Masum Chowdhury 45
How to promote Tibone ® with Doctors
Refresh your product knowledge of Tibone ® ® by
reviewing the action plan to detail the brand confidently to
the target Doctors.
Select and make a list of Gynaecologists in your
territory for promoting Tibone ®
Request your genuine customers (Doctors) to
prescribe one more prescription per day.
Highlight the surprising news about HRT and
highlight that hormone replacement therapy is the
basic Right of every women
46. Launching Tibone® Tablet By MD.
Masum Chowdhury 46
• Highlight that Tibone® therapy during menopause
protects bone mass and helps protect against the risk
of osteoporotic fractures.
• Highlight that Tibone® successfully prevent the Hot
flushes, night sweats, Decreased libido, vaginal
dryness. Osteoporosis etc.
• Please identify the Doctors who are currently
prescribing Ubilon /Livial® offer them the benefits
and reasonable price of Tibone® and ensure
prescriptions generation from them.
How to promote Tibone ® with Doctors
48. Launching Tibone® Tablet By MD.
Masum Chowdhury 48
Pack size and Price Information's
Brand
Name
Generic
Name
Dosage
Form
Pack
Size
MRP
Tibone ® Tibolone
lNN 2.5 mg
Tablet 3x10
Tablets
Tk.
450.00
49. Launching Tibone® Tablet By MD.
Masum Chowdhury 49
Major Competitors
Brand
Name
Company
Name
Dosage
Form
Pack Size MRP
Livial Organon Tablet 1x28
Tablets
Tk.
1100.00
Ubilon Incepta Tablet 3x10
Tablets
Tk.
600.00
50. Launching Tibone® Tablet By MD.
Masum Chowdhury 50
Major Responsibility
Aggressive Promotion to the Doctors, Chemist
Shop, Selective Society is needed.
51. Launching Tibone® Tablet By MD.
Masum Chowdhury 51
A Final Note About Tibone
Tibone – Improves Lives
Tibone – Extands Lives
Tibone – Save Lives
Tibone – One Tablet a Day Keeps Menopause Away
52. Launching Tibone® Tablet By MD.
Masum Chowdhury 52
Thank You Very Much
Believe in Yourself,
Wish you a Great Success
Keep Win – Win Attitude
53. Present Position (June 7, 2013)
Masum Chowdhury
Manager,
Strategic Brand Management Department
Asiatic Laboratories Ltd.
masum.pha@gmail.com,
+880-0171-7642874, +880-0193 7990014