Dydrogesterone is a progestin hormone used to regulate the healthy growth and shedding of the womb lining. It was first introduced in 1961 and is now approved in over 100 countries. It works by selectively binding to progesterone receptors and has an active metabolite called 20α-dihydrodydrogesterone that is non-sedative. Dydrogesterone is used orally at doses of 5-40 mg daily or via intramuscular injection of 100 mg daily to treat menstrual disorders, prevent miscarriage, treat endometriosis, support fertility, and prevent thickening of the uterine lining during hormone replacement therapy. Common side effects include headaches, breast pain or tenderness, spotting, and changes to menstrual periods

1.  DYDROGESTERONE
Introduction-
 It is a progestin which is a female hormone.
 This works by regulating the healthy growth and normal
shedding of the womb lining.
 Firstly, introduced in 1961, now currently approves by
over 100 countries.

2. PHARMACODYNAMICS
1) INTERACTION –
It is highly selective progestogen.
Binds to Progesterone Receptor (PR)
PR-A, PR-B

3. 2) Active Metabolite
Non-sedative
20 α –
dihydrodydrogesterone
(20α-DHD)

4. 3) DOSAGE
Oral
dosage
• 5-40 mg/day
• On 5 days interval
Intramuscular
injection
• 100 mg/day
• As microcrystalline aqueous suspension.

5. PHARMACOKINETICS
(I) ABSORPTION-
Active
Cons.-
• 20α-DHD
Bio-Availability
• 28%
Peak - Availability
• 1.5 Hours after post dose

6. (II) DISTRIBUTION
Protein-Binding site
unknown
Probably - Albumin

7. (III) METABOLISM
In Liver • Completely
metabolised
Process • Hydrogenation
Complete
el. time
• 14-17
hours

8. (IV) EXCRETION
Through
Urine
Within 72
Hours
Complete
excretion

9. CHEMISTRY
 OVER-DOSE-
 No major side effects noted during clinical trails, as given 4,000 mg to mice.
 SYNTHESIS-
 Treatment of progesterone with UV light exposure.
 BRAND NAME-
 Marketed under Duphastone and Femoston.
 REFERNCE-
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10.  INDICATIONS OF DYDROGESTERONE-
 Menstrual disorders: it is used for treating menstrual disorders like absent or irregular
menstruation, painful menstruation, secondary amenorrhea and premenstrual symptoms.
 Prevent miscarriage: Since the drug helps in maintaining integrity of the endometrial
lining in a pregnant womb, it is used for preventing habitual and recurrent abortion.
 Endometriosis: Dydrogesterone relieves the pain during menstruation due to
endometriosis without inhibiting ovulation.
 Infertility: The drug is used during IVF (in-vitro fertilization) cycle to achieve successful
implantation.
 In combination with hormonal replacement therapy (HRT): Dydrogesterone prevents
thickening of the uterine lining in the patient taking HRT.

11. DOSAGE -
1. Dysfunctional bleeding – 10 mg twice daily for a week for stopping bleeding.
2. Painful menstruation and irregular Menstrual periods – 10 mg twice daily
starting from the 5th day of menstrual cycle to 25th day.
3. Abortion – In case of threatened abortion, 40mg immediately and then 10 mg dose
repeated every 8 hours till remission.
4. Infertility – 10mg once daily from the 14th day till 25th day of menstrual cycle.
What are the side effects of Dydrogesterone?
 Pulsating headache which can develop into a migraine
 Pain in breast and breast tenderness
 Occasional blood spotting
 Pain during periods
 Irregular period
 Heavy bleeding during periods
 Missed period
 Weight gain
 Depression
 Hypersensitivity