Speaker Presentation from U.S. News Healthcare of Tomorrow leadership summit, Nov. 1-3, 2017 in Washington, DC. Find out more about this forum at www.usnewshot.com.

1. Robert H. Vonderheide, MD, DPhil
Director
Abramson Cancer Center
Perelman School of Medicine
University of Pennsylvania

2. The Cancer Genetics Era
Peter C. Nowell, MD
1928-2016
Revolutionized our
understanding of cancer

3. Stroma
Metabolism
Epigenome
Germline
Big data
Deep data
Proteome
Genetics
Immune
System
Vasculature
Tumor cell
The Cancer Ecology Era

4. The Cancer Immune Revolution:
T cells attack cancer
T cell
Tumor
cell

5. CAR T cell FDA-approval Flash Mob at Penn
August 30, 2017

6. Find
Driver
Tumor
Mutations
Match to
Targeted
Therapies
Find
All
Tumor
Mutations
and
Proteins
Identify
Immune
Targets
Identify all the
surrounding
immune cells
and immune
checkpoints
Precision
Oncology
CANCER
WORKUP
Now
Next

7. Tumor Genetics Cancer Immunology

8. Routine Medical Workup
Echo
Blood
tests
EP test
EKG
Cath
HEART
Bronch
Chest
CT
Chest
Xray
PFTs
LUNG
Neuro-
psych
tests
EEG
MRI
Head
CT
BRAIN
Blood
tests
Ultra-
soundUrine
test
KIDNEY
Blood
tests
Ultra-
soundColon-
oscopy
GI TRACT
White
blood
count
IMMUNE

9. Immune profiling
Immunotherapy drugs
Biosamples
Cellular immunotherapy
“Immune Health”
Bioinformatics