Gravity model, Epidemiology and Real-time reproduction number (Rt) estimation...Bhoj Raj Singh
Coronavirus disease (COVID-19) originated in China during the mid of December 2019 caused global havoc. The World Health Organization (WHO) declared the COVID-19 as an International Public Health Emergency on 30th January 2020 and subsequently as a pandemic on 11th March 2020. The disease has affected almost all the countries of the world and as on 30th July 2020 there were 16.5 million cases and 0.65 million deaths are reported. The members of South Asian Association for Regional Cooperation (SAARC) are Afghanistan, Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka sharing 3% of the world's area and 21% of the world's population. We analysed the COVID-19 data as on 1st July 2020 retrieved from publically available databases. The gravity model is primarily used in the transportation industry and gaining importance in the modelling of the spread of infectious diseases. In this analysis, we observed that higher personal freedom or movement of people is having the greatest effect on the spread of COVID-19 (coefficient = 2.1). The correlation analysis was carried out with COVID-19 cases, health expenditure, poverty, and BCG vaccination, literacy, and population density of the SAARC countries. The COVID-19 positive cases showed a significant (p<0.001) positive correlation (r=0.99) with mortality rate. Similarly, the COVID-19 deaths showed a significant positive correlation with health expenditure (% GDP) (r = 0.58, p<0.05). The other epidemiological factors such as population density/sq km, literacy %, adult population %, and poverty % didn’t show any significant correlation with COVID-19 cases and deaths. The estimation of weekly Real-time reproduction number (Rt) among SAARC countries showed the highest Rt in India (Rt =2.1; 95% CI 2.05 – 2.2) followed by Bangladesh (Rt =1.6; 95% CI 1.5– 1.6). The comparison of Rt indicated that a decrease in the Rt value was noticed in the later stage of the period (past few weeks) among all the SAARC countries compared with the initial stage of infection except Nepal. The analysis indicates that implementation of restrictions, large scale screening and intensive monitoring is mandatory in all countries in order to reduce the Covid-19 spread.
Impact of covid 19 vaccination on reduction of covid-19 cases and deaths duri...Bhoj Raj Singh
The presentation details the analytical results of the impact of COVID-19 vaccination on the number of cases and number of deaths due to COVID-19 in India and at the global level. The presentation also discussed the ways to control the COVID-19 and the role of Herd-Immunity.
Comparative antimicrobial activity of aspirin, paracetamol, flunixin meglumin...Bhoj Raj Singh
• Some of the tested drugs (NSAIDs including aspirin, diclofenac, meloxicam & flunixin meglumine) possess broad-spectrum antimicrobial activity but not in therapeutically achievable non-toxic concentrations in the body. Paracetamol was the least effective as antimicrobial similar to pheniramine maleate.
• A few of the NSAIDs may be evaluated as topical use antimicrobials (aspirin, diclofenac & flunixin) being microbial growth inhibitors at 0.128% concentration, similar levels of antimicrobial drugs including antibiotics are often used in topical antiseptic preparations (gels/ ointments/creams/powders/ lotions).
• Studies should be conducted on synergism/ antagonism of NSAIDs with commonly used antibiotics and herbal antimicrobials so that antimicrobial potential of NSAIDs can be therapeutically utilized.
• Susceptibility of bacteria to NSAIDs may be an aid in the differentiation of a few bacteria like Klebsiella and Raoultella; Enterococcus and Streptococcus (meloxicam); Bacillus and Paenibacillus (Diclofenac). However, multicentric studies on a greater number of strains are essential to establish the difference.
Gravity model, Epidemiology and Real-time reproduction number (Rt) estimation...Bhoj Raj Singh
Coronavirus disease (COVID-19) originated in China during the mid of December 2019 caused global havoc. The World Health Organization (WHO) declared the COVID-19 as an International Public Health Emergency on 30th January 2020 and subsequently as a pandemic on 11th March 2020. The disease has affected almost all the countries of the world and as on 30th July 2020 there were 16.5 million cases and 0.65 million deaths are reported. The members of South Asian Association for Regional Cooperation (SAARC) are Afghanistan, Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka sharing 3% of the world's area and 21% of the world's population. We analysed the COVID-19 data as on 1st July 2020 retrieved from publically available databases. The gravity model is primarily used in the transportation industry and gaining importance in the modelling of the spread of infectious diseases. In this analysis, we observed that higher personal freedom or movement of people is having the greatest effect on the spread of COVID-19 (coefficient = 2.1). The correlation analysis was carried out with COVID-19 cases, health expenditure, poverty, and BCG vaccination, literacy, and population density of the SAARC countries. The COVID-19 positive cases showed a significant (p<0.001) positive correlation (r=0.99) with mortality rate. Similarly, the COVID-19 deaths showed a significant positive correlation with health expenditure (% GDP) (r = 0.58, p<0.05). The other epidemiological factors such as population density/sq km, literacy %, adult population %, and poverty % didn’t show any significant correlation with COVID-19 cases and deaths. The estimation of weekly Real-time reproduction number (Rt) among SAARC countries showed the highest Rt in India (Rt =2.1; 95% CI 2.05 – 2.2) followed by Bangladesh (Rt =1.6; 95% CI 1.5– 1.6). The comparison of Rt indicated that a decrease in the Rt value was noticed in the later stage of the period (past few weeks) among all the SAARC countries compared with the initial stage of infection except Nepal. The analysis indicates that implementation of restrictions, large scale screening and intensive monitoring is mandatory in all countries in order to reduce the Covid-19 spread.
Impact of covid 19 vaccination on reduction of covid-19 cases and deaths duri...Bhoj Raj Singh
The presentation details the analytical results of the impact of COVID-19 vaccination on the number of cases and number of deaths due to COVID-19 in India and at the global level. The presentation also discussed the ways to control the COVID-19 and the role of Herd-Immunity.
Comparative antimicrobial activity of aspirin, paracetamol, flunixin meglumin...Bhoj Raj Singh
• Some of the tested drugs (NSAIDs including aspirin, diclofenac, meloxicam & flunixin meglumine) possess broad-spectrum antimicrobial activity but not in therapeutically achievable non-toxic concentrations in the body. Paracetamol was the least effective as antimicrobial similar to pheniramine maleate.
• A few of the NSAIDs may be evaluated as topical use antimicrobials (aspirin, diclofenac & flunixin) being microbial growth inhibitors at 0.128% concentration, similar levels of antimicrobial drugs including antibiotics are often used in topical antiseptic preparations (gels/ ointments/creams/powders/ lotions).
• Studies should be conducted on synergism/ antagonism of NSAIDs with commonly used antibiotics and herbal antimicrobials so that antimicrobial potential of NSAIDs can be therapeutically utilized.
• Susceptibility of bacteria to NSAIDs may be an aid in the differentiation of a few bacteria like Klebsiella and Raoultella; Enterococcus and Streptococcus (meloxicam); Bacillus and Paenibacillus (Diclofenac). However, multicentric studies on a greater number of strains are essential to establish the difference.
coronavirus vaccine latest update and impact on people's lives.COVID vaccine race will win a huge market. what about poor countries, the vaccine will be available for developed countries, pharma companies already make their statement about vaccine availability price .
We Analyzed 1 Million Articles about Covid Vaccines. Here’s What We Found!Social Animal
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.
Ever since The World Health Organization (WHO) declared the Coronavirus outbreak as a Public Health Emergency of International Concern on 30 January 2020, and a pandemic on 11 March 2020, scientists from all over the world have been scrambling to create a vaccine.
During this period, vaccine development was expedited and scientists faced various challenges in creating a working vaccine.
The urgency to create a vaccine led to “compressed schedules” where trials for vaccines, which usually take years, were conducted over a period of months.
Since then, Several vaccines have been approved for mass vaccination drives against COVID-19 and have been distributed globally.
However, the community’s knowledge, attitudes, and perceptions towards these vaccinations are poorly understood.
We analyzed 1M articles that contained the mentions of various vaccines and here’s what we found.
✔✔ Conversations about Pfizer have received more engagement on Twitter as Pfizer has shown the highest efficacy rate of 95%.
✔✔ Moderna has an efficacy of 94.1% against covid infection and the engagement shows that articles that mention Moderna had lesser engagement than Pfizer but considerably more than other vaccines.
✔✔ AstraZeneca ranks third when it comes to Twitter engagement among popular vaccines.
✔✔ Russia’s Sputnik vaccine claims a 95% efficacy rate, even before beginning a Phase III trial. But conversations and engagement on Twitter have been minimal.
✔✔ Covaxin and Novavax have had some conversations and mentions on Twitter, unlike Janssen, a vaccine that has had the least engagement.
You can find more interesting data in our report!
(EN) 2021 COVID-19 Vaccines Social Buzz Insight Report [SM2Networks]디센트릭 DnA팀
This is a report that analyzes the responses and reputations of the COVID-19 vaccines by country.
We conducted in-depth data analysis such as engagement and correlation as well as simple quantitative analysis of social data generated in Korea, China, Japan and 7 countries with a large number of coronavirus confirmed cases.
If you have any questions about this report, please contact the SM2Networks Marketing Intelligence Team.
Web : www.sm2marketing.co.kr
E-mail : marketing@samhwa.com
Blog_1: https://blog.naver.com/synthesio
Blog_2 : https://blog.naver.com/dmktginsight
Tel : 031-478-1570
#COVID19 #coronavirus #corona vaccine #coronavirus vaccine #COVID vaccine #pfizer #astrazeneca #moderna #sinovac #sinopharm #janssen #novavax
Know your COVID-19 Vaccine (Philippines)AxcelPerez1
The content aims to contribute spreading right information about COVID-19 Vaccine. The information are from World Health Organization and Philippine Department of Health. This may help my fellow Filipino to build his/her confidence to get vaccinated.
Strength and weaknesses of fmd control programme going on in india dr. kale b...Bhoj Raj Singh
Foot and Mouth Disease (FMD) is a devastating disease in many of the developing countries including India despite control programs. The FMD in India is associated with loss of about Rs. 20000 crores per annually. Government of India and different provincial governments are spending hundreds of crore rupees per year to control the disease. The FMD control programme (FMD-CP) is running in India since more than 13 years but control of the FMD is still far away dream and the Disease is regularly visiting even the government farms managed by the India's leading Veterinary and Dairy Institutes. The pros and cons of FMD-CP has been discussed in the presentation.
These slides highlight the approved & widely used vaccines for immunization against COVID-19 (as of end Q1 2021). At the time of writing, there are 3 COVID-19 vaccines that have been granted Emergency Use Authorization by the US FDA, 2 of which are using mRNA platforms.
COVID-19 is certainly a newly emerged zoonosis, not yet understood properly thus cases need utmost care in its handling in both in human and animals.
More observations and studies can only elucidate the origin, intermediate host and definitive host (till date humans) and maintenance host of SARS CoV-2.
For control of emerging and re-emerging zoonoses potentiating one health environmental approach for understanding disease drivers and control strategies are essential elements.
Vaccines (Immunotherapy) along with COVID-19 Overview, Types of Vaccines, Adjuvants, Antigen Uptake Mechanism, COVID-19 Mechanism Of Action, and much more.
Current Status and Future Perspective of Rapid Diagnostic Kits Vaccine agains...ijtsrd
Coronavirus disease 2019 COVID 19 , which causes serious respiratory illness such as pneumonia and lung failure, was first reported in Wuhan, the capital of Hubei, China. The etiological agent of COVID 19 has been confirmed as a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 SARS CoV 2 , which is most likely originated from zoonotic coronaviruses, like SARS CoV, which emerged in 2002. Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus 2019 nCoV outbreak. Currently, various diagnostic kits to test for COVID 19 are available and several repurposing therapeutics for COVID 19 have shown to be clinically effective. In addition, global institutions and companies have begun to develop vaccines for the prevention of COVID 19. Here, we review the current status of, diagnosis, and vaccine development for COVID 19. M A Nandedkar | R A Shinde | S S Bansode "Current Status and Future Perspective of Rapid Diagnostic Kits / Vaccine against COVID-19" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd30977.pdf Paper Url :https://www.ijtsrd.com/pharmacy/analytical-chemistry/30977/current-status-and-future-perspective-of-rapid-diagnostic-kits--vaccine-against-covid19/m-a-nandedkar
The Future Landscape of Covid-19 Vaccine MarketMehdiMehdiyev4
We believe that assessing the potential market for COVID-
19 vaccines is necessary in terms of reevaluating the risk/reward ratio of certain vaccine developing companies.
In addition, an overly utopian outlook for a potential COVID-19 vaccine market may lead to
disappointment and negatively affect future vaccine developers. And this concerns us more.
Markets around the globe are rallying on news that Pfizer’s Covid-19 vaccine is more than 90% effective in preventing the disease. How can you best profit from the Covid-19 vaccine market rally?
https://youtu.be/G6Zd-uFbCNU
In this section of the coronavirus pandemic series, we discuss the current capacity of local healthcare systems and the need for effective treatment options as well as the pathogenesis of the coronavirus. Current treatment options include RNA, monoclonal antibodies (mAb), antibodies, convalescent plasma, and others. Critical stage implications such as cytokine storm and the need for immunomodulatory agents would also be discussed. Therapeutic pathways would are also compared.
MRC/info4africa KZN Community Forum | May 2012info4africa
Dr Shay Ganesh, Clinical Manager at medical Research Council in the HIV Prevention, Treatment and Wellness Unit presented on local and global HIV prevention efforts, focusing on previous, current and future programmes. Dr Ganesh looked towards Pre-Exposure Prophylaxis as a possible future prevention programme and gave some insight into possible programmatic and public health challenges involved in rolling out new HIV prevention programmes.
coronavirus vaccine latest update and impact on people's lives.COVID vaccine race will win a huge market. what about poor countries, the vaccine will be available for developed countries, pharma companies already make their statement about vaccine availability price .
We Analyzed 1 Million Articles about Covid Vaccines. Here’s What We Found!Social Animal
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.
Ever since The World Health Organization (WHO) declared the Coronavirus outbreak as a Public Health Emergency of International Concern on 30 January 2020, and a pandemic on 11 March 2020, scientists from all over the world have been scrambling to create a vaccine.
During this period, vaccine development was expedited and scientists faced various challenges in creating a working vaccine.
The urgency to create a vaccine led to “compressed schedules” where trials for vaccines, which usually take years, were conducted over a period of months.
Since then, Several vaccines have been approved for mass vaccination drives against COVID-19 and have been distributed globally.
However, the community’s knowledge, attitudes, and perceptions towards these vaccinations are poorly understood.
We analyzed 1M articles that contained the mentions of various vaccines and here’s what we found.
✔✔ Conversations about Pfizer have received more engagement on Twitter as Pfizer has shown the highest efficacy rate of 95%.
✔✔ Moderna has an efficacy of 94.1% against covid infection and the engagement shows that articles that mention Moderna had lesser engagement than Pfizer but considerably more than other vaccines.
✔✔ AstraZeneca ranks third when it comes to Twitter engagement among popular vaccines.
✔✔ Russia’s Sputnik vaccine claims a 95% efficacy rate, even before beginning a Phase III trial. But conversations and engagement on Twitter have been minimal.
✔✔ Covaxin and Novavax have had some conversations and mentions on Twitter, unlike Janssen, a vaccine that has had the least engagement.
You can find more interesting data in our report!
(EN) 2021 COVID-19 Vaccines Social Buzz Insight Report [SM2Networks]디센트릭 DnA팀
This is a report that analyzes the responses and reputations of the COVID-19 vaccines by country.
We conducted in-depth data analysis such as engagement and correlation as well as simple quantitative analysis of social data generated in Korea, China, Japan and 7 countries with a large number of coronavirus confirmed cases.
If you have any questions about this report, please contact the SM2Networks Marketing Intelligence Team.
Web : www.sm2marketing.co.kr
E-mail : marketing@samhwa.com
Blog_1: https://blog.naver.com/synthesio
Blog_2 : https://blog.naver.com/dmktginsight
Tel : 031-478-1570
#COVID19 #coronavirus #corona vaccine #coronavirus vaccine #COVID vaccine #pfizer #astrazeneca #moderna #sinovac #sinopharm #janssen #novavax
Know your COVID-19 Vaccine (Philippines)AxcelPerez1
The content aims to contribute spreading right information about COVID-19 Vaccine. The information are from World Health Organization and Philippine Department of Health. This may help my fellow Filipino to build his/her confidence to get vaccinated.
Strength and weaknesses of fmd control programme going on in india dr. kale b...Bhoj Raj Singh
Foot and Mouth Disease (FMD) is a devastating disease in many of the developing countries including India despite control programs. The FMD in India is associated with loss of about Rs. 20000 crores per annually. Government of India and different provincial governments are spending hundreds of crore rupees per year to control the disease. The FMD control programme (FMD-CP) is running in India since more than 13 years but control of the FMD is still far away dream and the Disease is regularly visiting even the government farms managed by the India's leading Veterinary and Dairy Institutes. The pros and cons of FMD-CP has been discussed in the presentation.
These slides highlight the approved & widely used vaccines for immunization against COVID-19 (as of end Q1 2021). At the time of writing, there are 3 COVID-19 vaccines that have been granted Emergency Use Authorization by the US FDA, 2 of which are using mRNA platforms.
COVID-19 is certainly a newly emerged zoonosis, not yet understood properly thus cases need utmost care in its handling in both in human and animals.
More observations and studies can only elucidate the origin, intermediate host and definitive host (till date humans) and maintenance host of SARS CoV-2.
For control of emerging and re-emerging zoonoses potentiating one health environmental approach for understanding disease drivers and control strategies are essential elements.
Vaccines (Immunotherapy) along with COVID-19 Overview, Types of Vaccines, Adjuvants, Antigen Uptake Mechanism, COVID-19 Mechanism Of Action, and much more.
Current Status and Future Perspective of Rapid Diagnostic Kits Vaccine agains...ijtsrd
Coronavirus disease 2019 COVID 19 , which causes serious respiratory illness such as pneumonia and lung failure, was first reported in Wuhan, the capital of Hubei, China. The etiological agent of COVID 19 has been confirmed as a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 SARS CoV 2 , which is most likely originated from zoonotic coronaviruses, like SARS CoV, which emerged in 2002. Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus 2019 nCoV outbreak. Currently, various diagnostic kits to test for COVID 19 are available and several repurposing therapeutics for COVID 19 have shown to be clinically effective. In addition, global institutions and companies have begun to develop vaccines for the prevention of COVID 19. Here, we review the current status of, diagnosis, and vaccine development for COVID 19. M A Nandedkar | R A Shinde | S S Bansode "Current Status and Future Perspective of Rapid Diagnostic Kits / Vaccine against COVID-19" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd30977.pdf Paper Url :https://www.ijtsrd.com/pharmacy/analytical-chemistry/30977/current-status-and-future-perspective-of-rapid-diagnostic-kits--vaccine-against-covid19/m-a-nandedkar
The Future Landscape of Covid-19 Vaccine MarketMehdiMehdiyev4
We believe that assessing the potential market for COVID-
19 vaccines is necessary in terms of reevaluating the risk/reward ratio of certain vaccine developing companies.
In addition, an overly utopian outlook for a potential COVID-19 vaccine market may lead to
disappointment and negatively affect future vaccine developers. And this concerns us more.
Markets around the globe are rallying on news that Pfizer’s Covid-19 vaccine is more than 90% effective in preventing the disease. How can you best profit from the Covid-19 vaccine market rally?
https://youtu.be/G6Zd-uFbCNU
In this section of the coronavirus pandemic series, we discuss the current capacity of local healthcare systems and the need for effective treatment options as well as the pathogenesis of the coronavirus. Current treatment options include RNA, monoclonal antibodies (mAb), antibodies, convalescent plasma, and others. Critical stage implications such as cytokine storm and the need for immunomodulatory agents would also be discussed. Therapeutic pathways would are also compared.
MRC/info4africa KZN Community Forum | May 2012info4africa
Dr Shay Ganesh, Clinical Manager at medical Research Council in the HIV Prevention, Treatment and Wellness Unit presented on local and global HIV prevention efforts, focusing on previous, current and future programmes. Dr Ganesh looked towards Pre-Exposure Prophylaxis as a possible future prevention programme and gave some insight into possible programmatic and public health challenges involved in rolling out new HIV prevention programmes.
Anti-microbial resistance has become a world health issue today. Therefore it is imperative to know about the methods of acquiring resistance and ways to deal with the situation and prevent resistance.
The International Journal of Engineering and Science (The IJES)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
From Discovery to Delivery: Benchwork to Global Health: Shiu-Lok HuUWGlobalHealth
Explores relationships and discrepancies between important research-based medical advancements and subsequent real world implementation. Advancements in the management and potential elimination of infectious diseases such as HIV and TB will be addressed, as related to development and implementation of effective diagnostics, vaccines, or treatments.
ABSTRACT- Human immunodeficiency virus (HIV) is a major contributor to the global burden of the disease, opportunistic infections, and tumors follow. HIV also directly attacks the immune system and affects certain body’s system (like Central Nervous System, Respiratory and Cardiovascular Systems, Digestive System etc). HIV transmission is complex and depends on the number of behavioral and biological co-factors. The hallmark of HIV infection is the progressive depletion of CD4 helper T cells because of reduced production and increased destruction. Although the typical HIV infected patient shows a sustained CD4 cell increase, a remarkable number of subjects never achieve normal ranges of CD4. HIV infection is also characterized by a marked increase in immune activation, which includes both the adaptive and innate immune systems and abnormalities in coagulation. Extraordinary efforts in the fields of clinical, pharmacology, and biology care have contributed to progressively turn HIV infection from an unavoidably fatal condition into a chronic manageable disease, at least in the countries where HIV infected people have full access to the potent anti-retroviral (ARV) drug combinations that permit a marked and sustained control of viral replication. Although their pathogenesis is still under discussed, they are likely to originate from immune dysfunction associated with HIV infection and chronic inflammation. The last consideration regards the dis-homogenous pattern of HIV disease worldwide. Key-words- Human immunodeficiency virus (HIV), simian immunodeficiency viruses (SIV), Antiretroviral (ARV) therapy, Acquired immunodeficiency syndrome (AIDS), Cell mediated immunity (CMI), Anti-retroviral agents
Sustaining community involvement in HIV prevention research:Experiences fro...wellcome.trust
Presented by William Kidega (UVRI-IAVI HIV Vaccine Program) at the Public Engagement Workshop, 2-5 Dec. 2008, KwaZulu-Natal South Africa, http://scienceincommunity.wordpress.com/