Epithelial tissue lines body surfaces and cavities and forms glands. It has several key characteristics: it protects underlying tissues, regenerates quickly, is avascular, and is polarized with selectively permeable cells. Epithelial tissue includes glandular epithelium which forms two types of glands - endocrine glands that release secretions into the bloodstream and exocrine glands that secrete into ducts leading outside or inside the body. Exocrine glands are classified by their secretory mechanisms and structures.
What is a Gland?
An organised collection of secretory epithelial cells. Most glands are formed during development by proliferation of epithelial cells so that they project into the underlying connective tissue. Some glands retain their continuity with the surface via a duct and are known as EXOCRINE GLANDS. Other glands lose this direct continuity with the surface when their ducts degenerate during development. These glands are known as ENDOCRINE glands.
epithelium covers body surfaces, lines body cavities and constitute glands.so it is important to know about epithelium in detail to deal with tissue of different type and origin.
What is a Gland?
An organised collection of secretory epithelial cells. Most glands are formed during development by proliferation of epithelial cells so that they project into the underlying connective tissue. Some glands retain their continuity with the surface via a duct and are known as EXOCRINE GLANDS. Other glands lose this direct continuity with the surface when their ducts degenerate during development. These glands are known as ENDOCRINE glands.
epithelium covers body surfaces, lines body cavities and constitute glands.so it is important to know about epithelium in detail to deal with tissue of different type and origin.
B.Pharm-Ist sem-HAP-Chapter 3-tissue level of organization.pptxSheetal Patil
Introduction
The term tissue is used to describe a group of cells found together in the body.
Types of tissues
1. Epithelial tissue:]
2. Connective tissue: ]
3. Muscular tissue: ]
4. Nervous tissue: ]
-Development of Tissues
Tissues of the body develop from three primary germ layers: Ectoderm, Endoderm and Mesoderm.
1. Epithelial cell
Epithelial tissue consists of cells arranged in continuous sheets, in either single or multiple layers.
Closely packed and held tightly together.
-General Features of Epithelial Cells:
1. Apical (free) surface
2. Lateral surfaces
3. Basal surface
Basement membrane
Basal lamina
Reticular lamina
-Classification of epithelial tissues
Epithelial tissues are classified according to :
Number of the cell layers formed
1. Simple epithelium (one layer)
2. Stratified epithelium(several layer)
-The shape of the cells
1. Squamous (flat cell)
2. Cuboidal (cube like)
3. Columnar (rectangular)
4. Transitional (variable)
- Glandular Epithelium and Glands
There are main two types of glands
1. Endocrine Glands
2. Exocrine Glands
-Structural Classification of Exocrine Glands
1. Simple gland
2. Compound gland
-Functional Classification of 1. Exocrine Glands
2. Merocrine glands
3. Aprocrine glands
4. Holocrine glands
2. Connective Tissue
-Functions of connective tissues
-Classification of Connective Tissues
Embryonic connective tissue
Mesenchyme
Mucous connective tissue
Mature connective tissue
Loose connective tissue
Areolar connective tissue
Adipose tissue
Reticular connective tissue
Dense connective tissue
Dense regular connective tissue
Dense irregular connective tissue
Elastic connective tissue
Cartilage
Hyaline cartilage
Fibrocartilage
Elastic cartilage
Bone tissue
-Blood and Lymph
--Characteristics of Connective Tissue
1. Extra cellular matrix
2. Fibers
3. Cells of various types
Extracellular matrix of Connective Tissue
-Connective Tissue Cells
1. Fibroblasts
2. Adipocytes (fat cells)
3. Mast cells
4. White blood cells
5. Macrophages
6. Plasma cells
-Connective Tissue Extracellular Matrix;
Ground substance and fibres make up the ECM.
a. Ground substance
-Complex combination of proteins and polysaccharides (hyaluronic acid, chondroitin sulphate dermatan sulphate and keratan sulphate).
b. Fibres
-Collagen fibers
-Elastic fibers
-Reticular fibers
3. Muscular Tissue
-Skeletal muscle tissue (Attached to bone by tendons)
-Cardiac muscle tissue (Heart wall)
-Smooth muscle tissue (Iris of eyes, walls of hollow internal structures such as blood vessels, airways of lungs, stomach, intestine, gall bladder, urinary bladder and uterus)
--Consists of elongated cells called muscle fibers or myocytes for contraction.
--Cells use ATP to generate force.
4. Nervous Tissue
-Neurons or nerve cells
-Neuroglia
--Exhibit sensitivity to various types of stimuli, converts them into nerve impulses (action potentials) and conducts nerve impulses to other neurons.
What is tissue?
Tissue is a group of cells which work together to perform a particular
functions.
Several kinds of tissue grouped together to form an organ.
Branch of biology that deals with the study of tissue is known as histology.
Word animal tissue was coined by – Bichat
Study of tissue – Histology
Histology word was given by – Mayar
Father of Histology – Bichat
Study of tissue is also called Microscopic anatomy.
Founder of microscopic anatomy – Marcello Malpighi
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
5. PSEUDOSTRATIFIED COLUMNAR EPITHELIUM
- is a falsely striated tissue (and therefore a
single layer of cells) composed of columnar
shaped cells that line an organ or cavity
space.
Function: Cilia may be present, along w/
mucus-secreting goblet cells, that line and
sweep debris from respiratory tubes.
Example: Lining of nasal cavity, trachea,
and bronchi: secretion of mucus by goblet
cells. These columnar cells have cilia that
move mucus toward the pharynx.
6. PSEUDOSTRATIFIED CILIATED AND NONCILIATED
Nonciliated cells lack cilia and goblet cells.
Ciliated cells secrete mucus and bear cilia.
7. SPECIAL SURFACE MODIFICATIONS ON EPITHELIAL CELLS
Cilia are motile structures found on certain cells in the uterine tubes, uterus,
efferent ducts in the testes, and conducting tubes of the respiratory system.
Microvilli are small, nonmotile projections th at cover the surfaces of all
absorptive cells in the small intestine and the proximal convoluted tubules in
the kidney.
Stereocilia are long, nonmotile, branched microvilli that line the cell surfaces
in the epididymis and vas deferens.
• The function of microvilli and stereocilia is absorption and Cilia for
movement.
8. PSEUDOSTRATIFIED CILIATED AND NONCILIATED
Nonciliated cells lack cilia and goblet cells.
Ciliated cells secrete mucus and bear cilia.
12. “Our body needs an order to function..”
“Organs and systems itself also
needs their PERSONAL SPACE”
13. PROPER EPITHELIUM
covers and lines your outer and inner body.
GLANDULAR EPITHELIUM
which forms glands and secretes hormones and other substances.
14. CHARACTERISTICS:
A. The epithelium does all to protect your deeper
layers of tissue from injury or infection.
B. All epithelial tissue is Avascular.
C.Epithelial tissue regenerates really quickly.
D.All of your epithelial cells are Polar.
E. They are selectively permeable.
15. C. EPITHELIAL TISSUE REGENERATES REALLY QUICKLY
• Epithelium have a high
regenerative capacity and
can reproduce rapidly as
long as they receive
adequate nutrition.
16. D. ALL OF YOUR EPITHELIAL CELLS ARE POLAR
• The apical or upper side is
exposed to either the outside of
your body or in lumen.
• The basal side or inner surface is
tightly attached to the basal
membrane, a thin layer of collagen
fibers that helps holds the
epithelium and anchor it to the
next deeper layer which is the
connective tissue.
17. E. THEY ARE SELECTIVELY PERMEABLE.
• Allowing for some level of
absorption, filtration and
secretion of substances.
19. GLANDULAR EPITHELIUM
Forms two kinds of glands:
Endocrine Glands: are ductless –
the connection with the surface
was obliterated during
development and they release their
secretory product (hormones) into
the bloodstream.
Exocrine Glands: the type that
secrete their juices into tubes or
ducts that lead to the outside of the
body, or the inside of your tube.
22. MECHANISMS OF EXOCRINE GLANDS SECRETION
1. Merocrine Gland: the
secretory product is released
by exocytosis; (e.g.
pancreas, salivary glands)
2. Holocrine Gland: the apical
part of cytoplasm of the cells
is lost together with the
secretory product; (e.g.
female mammary gland)
3. Apocrine Glands: breakdown
and discharge of the entire
secretory cell and its
product; (e.g. sebaceous
glands of the skin)
28. SUMMARY!
• how your epithelial tissue creates the
inner and outer boundaries that keep you
alive.
• how proper epithelial tissue is classified
by both layering (simple or stratified) and
shape (squamous cuboidal columnar)
• epithelial cells are polar (having both
apical and basal sides) and are selectively
permeable.
• a look at how our glandular epithelial
tissue forms both endocrine and exocrine
glands.
29. END. GOD BLESS
“Cells differentiate in the human body during development to perform their
special jobs. These specialized cells are grouped together as tissues. The
structures in the body have cellular arrangements that are closely related to
their functions showing again the hand of the Master Designer. The body is a
demonstration of Love. So it is expected that the lessons on the tissues would
be also the lessons of Love…”