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WHAT ARE THE
TABLETS ?
Tablet is defined as a
compressed solid dosage
form containing
medicaments with or
without excipients.
TYPES
OF
TABLETS
SUBLINGUAL
LOZENGES
EFFEVESCENT
HYPOD-
ERMIC
1)COMPRESSED TABLETS
2) MULTIPLE COMPRESSED TABLETS
3) MULTIPLE
COMPRESSED TABLETS
4) REPEAT ACTION
TABLET
7)CHOCOLATE COATED
8)FILM COATED
5)DELAYED ACTION AND
ENTERIC COATED TABLET
6) SUGAR COATED TABLET
9)AIR SUSPENSION
COATED
10) CHEWABLE
METHODS OF
MANUFACTUR
-ING TABLETS
1) WET GRANULATION:
(A)Weighing and blending the ingrediants.
(b)Preparing a damp mass.
(c)Screening the damp mass into pellets or
granules.
(d)Drying the granulation.
(e)Sizing the granulation by dry screening.
(f)Adding lubricant and blending .
(g) forming tablets by compression.
2) DRY GRANULATION:
By the dry granulation
method the powder mixture
is compacted in large pieces
and subsequently broken
down or sized into granules.
3) DIRECT COMPRESSION
TABLETING:
(a) Top punch is withdrawn from the die by the
upper cam bottom punch is low in the die so
powder falls in through the hole and fills the die.
(b) Bottom punch moves upto adjust the powder
weight it raises and expels some powder.
(c) Top punch is driven into the die by upper cam
bottom punch is raised by lower cam both punch
heads pass between heavy rollers to compress
powder.
(d) Top punch is withdrawn by the upper cam lower
punch is pushed up and expels the tablet is
removed from the die surface by surface plate.
Ingredients of tablets
Binders
Lubricants
Glidants
diluents
Flavourants
Colourants
ADVANTAGES
OF
TABLETS
simple and
convenient to use.
provide an accurately
measured dosage
of the active ingredient.
Their cost is
lowest of all oral
dosage form.
easy to mask the
part of bitter active
ingredient thus
make convenient
for patients.
formulated to contain
more than one
therapeutic ingredient
showing combination
thus reducing multiple
tablets use.
DISADVAN-
TAGES OF
TABLETS
1. Drugs w/c are amorphous & Low density character
are difficult to compress into tablets
2. Cost of production may be increase b/c of coating
& encapsulation to remove bitter & unpleasent
taste
3. Some tablets may cause problem in bioavailability
4. May be problematic for children and elder due to
difficulties in swallowing
5. Not suitable in emergency and unconscious
patients
6. Not appropriate if the patient suffers chronic
vomiting
Packaging of tablets:-
 It’s the science and art of protecting products
 Need of packaging
physical protection
barrier protection
agglomeration
security
convenience
dose control
Quality control of tablets
General appearance
Organoleptic properties
Quality control tests
for tablets
Tablet weight
Content uniformity
Tablet thickness
Tablet hardness and fribility
Tabelet disintegration

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Tablets