Defects of tablet.pdf

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This document lists various types of defects that can occur in tablet production including capping, lamination, chipping, cracking, sticking, picking, binding, mottling, double impression, weight variation, pitted surface, and film coating defects such as bridging, blistering, cratering, infilling, peeling, orange peel/roughness/pimpling, wrinkling, blushing, blooming, flaking and splitting. The document appears to be from Md. Jahidul islam in the Department of Pharmacy at JUST.

Education

Md. Jahidul islam
Department of Pharmacy, JUST

University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the tablets and its excipients and Ideal properties of tablet and the methods and equipment for there for manufacturing. Thank you for reading. Hope it was of help to you. UIPS,PU team

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Tablet Formulation Technology

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Tablets are solid dosage forms usually obtained by single or multiple compression of powders or granules. In certain cases tablets may be obtained by molding or extrusion techniques. They are uncoated or coated. Tablets are normally right circular solid cylinders, the end surfaces of which are flat or convex and the edges of which may be bevelled. They may have lines or break-marks (scoring), symbols or other markings.Tablets contain one or more active ingredients. They may contain excipients such as diluents, binders, disintegrating agents, glidants, lubricants, substances capable of modifying the behaviour of the dosage forms and the active ingredient(s) in the gastrointestinal tract, colouring matter authorized by the appropriate national or regional authority and flavouring substances. When such excipients are used it is necessary to ensure that they do not adversely affect the stability, dissolution rate, bioavailability, safety or efficacy of the active ingredient(s); there must be no incompatibility between any of the components of the dosage form. Tablets are single-dose preparations intended for oral administration. Some are intended to be swallowed whole, some after being chewed and some after being crushed, some are intended to be dissolved or dispersed in water before being taken and some are intended to be retained in the mouth where the active ingredient(s) is/are liberated.

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The most common method of drug delivery is oral dosage form of which tablet and capsule are predominant. Tablet is more accepted as compared to capsule due to many reason such as cost, tamper resistance, ease of handling, ease of identification and manufacturing efficiency. Tablet compression process understanding is resulted in development of formulation. Recent advances in the design of tablet compression equipment has conducted resulted in higher efficiency, minimized tablet variation, greater flexibility.

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