5. • Tablets: Solid preparations each containing
a single dose of one or more
ingredients and obtained by
uniform volumes of particles.
active
compressing
• They are used for local &
systemic effect.
• Usually used for oral administration.
6. Tablets are popular due to:
1. A convenient and safe way of drug
administration.
2. Compared to liquid dosage form they
more physically & chemically stable.
are
3. Enables more accurate dosing.
7. 4. Convenient to handle and can be
prepared in different ways according
their use.
to
5. They can be mass produced ,
with quality-controlled production
procedures giving an elegant
preparation of consistent quality
and low price.
8. Disadvantages of tablet:
1. It’s not suitable for poorly water-soluble
or poorly absorbable drugs
bioavailability.
less
2. Enhances local irritant effect
drugs or cause harm to the
gastrointestinal mucosa.
of some
3. Some drugs resist compression
into dense compacts.
9. Quality attributes of tablets:
1. The tablet should include the correct dose
of the drug.
2. The appearance of the tablet
elegant and its weight, size
and appearance should be
consistent.
should be
3. The drug should be released
from the tablet in a controlled
and reproducible way.
10. 4. The tablet should be biocompatible .
5. The tablet should be of sufficient
mechanical strength to withstand
fracture and erosion during handling.
6. The tablet should be
chemically, physically and
microbiologically stable
13. Tablet Manufacturing
Tablet Compression Machine
Design:
Hopper for holding and feeding granules or
powder to be compressed.
•
1.
2. Dies that define the size and shape
tablet.
Punches for compressing the
granules within the dies.
Cam tracks for guiding the
movement of the punches.
A feeding mechanism for
moving granules from the
hopper into the dies.
of the
3.
4.
5.
15. Tablet machine or tablet press
1,>pp er-----
anules�---�•
Eccontrlo
Clln"I
l.owc:ir punch
Plnotion
oollur
....,...,....,...,...C"'C".....:iF--,.,""""--Lift
Ino block
roguhHlllg
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-Weight
rc:,gul oll na
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16. Stages of Tablet Formation
(Compaction Cycle)
Die filling
Gravitational flow of the powder from
hopper via the die table into the die .
(The die is closed at its lower
punch).
end by the lower
Tablet formation
The upper punch descends,
enters the die ,the powder is
compressed until a tablet is formed.
- after maximum applied force is reached,
the upper punch leaves the powder.
17. Tablet ejection
The
the
The
the
lower punch rises until its tip reaches
level of the top of the die.
tablet is subsequently removed from
die and die table by
a pushing device.
18. The compression cycle for a single
punch tablet machine
First
Hopper
stage Second stage Third stage
1',.
Lower
Collection and filling
punch holder
Compression Ejection
20. Stages of Tablet Formation
(Compaction Cycle)
1. Forcing particles into close proximity to
each other by powder compression.
2. Compression takes place in a die by the
action of two punches (lower & upper).
Powder compression
The reduction in volume of a powder
owing to the application of a force.
compaction
The formation of a porous specimen of
defined geometry by powder compression.
22. 1. Single Punch press (Eccentric Press):
bench-top models that make one tablet at
a time (single-station presses)
Disadvantages: Production of
small batches of tablets
(200 tablets per minute).
23. 2. Rotary Press( Multi station Press):
• It was developed to increase the output of
tablets (10 000 tablets per minute), used for
Large scale production.
• It consists of a number of dies and sets
punches ( from 3 up to 60).
of
• The dies are mounted in a circle
table and both the die table &
the punches rotate together
in the die
during operation of the machine.
26. • The powder is held in a hopper whose lower
opening is located just above the die table.
• The powder flows on to the die table
die by a feed frame.
& fed into the
• During powder compression both
punches operate by vertical
movement.
• After tablet ejection, the tablet is
knocked away as the die passes the
feed frame.
29. Tablets Excipients
• Their role: To ensure that tablets of
specified quality are prepared.
• The common types
of tablet’s excipients
are described
figure.
in the
Filler
Disintegr
ant
Binder
Glidant
Lubricant
Anti-
adherent
Sorbent
Flavor
Colorant
&
Sweetene
rs
30. • Use: Increase the bulk volume of the
powder and hence the size of the tablet
suitable for handling .
Therefore, is not necessary if the
the drug per tablet is high.
Most common fillers in tablets:
Lactose.
Sugar or sugar alcohol (glucose,
sucrose, sorbitol and mannitol).
dose of
•
1.
2.
3.
4.
Cellulose and microcrystalline cellulose.
Dicalcium phosphate dihydrate.
31. •
1.
2.
3.
Requirements for a good filler:
Chemically inert, biocompatible, cheap.
Non-hygroscopic.
Good biopharmaceutical properties.
(water soluble or hydrophilic).
Good technical properties
(compactability )
Have an acceptable taste.
4.
5.
32. • Role: To ensure that the tablet, when in
contact with a liquid, breaks up into
small fragments, which promotes rapid
drug dissolution.
33. Steps of the disintegration process
• First: The liquid wets the solid and
penetrates the pores of the tablet
tablet breaks into smaller fragments
(aggregates of primary particles).
the
• Second: The aggregates will
deaggregate into their primary
powder particles.
34. Mode of action:
1. Facilitate water uptake into the pores of tablet,
e.g. surface active agents
2. Facilitate rupture of tablet by swelling
water sorption,
e.g. starch, modified cellulose
Release of gases to disrupt the
tablet structure, normally
carbon dioxide, in contact
with water. e.g. effervescent
tablets.
during
3.
4. Recovery of deformed particles
shape in contact with water.
to their original
35. The Method of Disintegrant Addition:
1. Mixed with other ingredients prior to
granulation & thus incorporated within the
granules (intragranular addition).
2. Mixed with the dry granules before the
complete powder mix is compacted
(extragranular addition).
3. Incorporated as both an
intragranular and an extragranular
portion.
36. Commonly Used Disintegrants:
1.Starch.
2.Cellulose (e.g. sodium
carboxymethyl cellulose).
- Typical concentration of 1-5%
weight
3. High swelling disintegrants
(Modified Starch or Modified
cellulose, in concentration of
by
1-2%
37. Starch
The typical concentration range of
•
starch in a tablet formulation
10%.
Mode of Action:
is up to
•
1. Starch particles swell in contact
with water and this swelling can
subsequently disrupt the tablet.
2. Facilitate disintegration by
particle-particle repulsion.
38. • Role: Ensure that granules and tablets
can be formed with the required
mechanical strength ( glue that holds
powders together to form granules ).
• Starch Paste
• Glucose
• Gelatin Solution
• Acacia
• Sucrose
• Sodium Alginate
39. Incorporation of binder
1. Dry Powder
- As dry powder mixed with other ingredient before wet
granulation
- As a dry powder in dry granulation (roller compaction,
slugging)
2. Solution binder
As a solution in wet granulation. Binder can be added
either dry with other excipients for granulation or already
dissolved in the granulating fluid; water is the most
common granulating fluid, very occasionally in a co-
solvent system with, e.g. ethanol.
40. • Typical binder concentration is 2 –
by weight
Binders can be:
10%
•
–
–
–
Insoluble in water, e.g. starch
Soluble in water e.g. HPMC
Soluble in water and ethanol e.g.
Povidone
41. • Role:
Lubricants prevent adherence of granule/powder
to die wall and to promote smooth
the die after compaction
ejection from
•
1.
2.
Mechanisms of Action :
Fluid lubrication.
Boundary lubrication.
42. •
•
1. Fluid lubrication
A layer of fluid is located between the
moving surfaces separating them from
each other & thus reduces the
e.g. liquid paraffin.
2. Boundary lubrication:
friction,
•
• The sliding surfaces are separated
by only a very thin film of lubricant.
So, the nature of the solid surfaces
will therefore affect friction.
43. Disadvantages of lubricants
• 1. Lubricants tend to be hydrophobic, so their
levels (typically 0.3 – 2%) need to be
optimised:
– Under-lubricated blends tend to flow poorly
and show compression sticking problems
Over-lubricated blends can adversely affect
tablet hardness and dissolution rate, as well
as tablet strength.
To overcome these problems;
- optimum conc. < 1%
- Addition of SAA
- order of mixing, in the last step
–
–
45. • Role: Improve flowability of the powder &
added during direct compaction and to
granulation before tabletting
interparticulate friction).
( they reducing
•
1.
2.
Common Glidants:
Talc ( at concentration
Colloidal silica ( 0.2 %
1-2 % ).
46. • Role: Reduce adhesion between the
powder and the punch faces &thus
prevent particles sticking to the punches;
due to excess moisture or engraved
embossed punch face.
and/or
• Many lubricants, such as
magnesium stearate, have
also antiadherent properties.
Also talc and starch can act
as antiadherents.
47. • Def.: Are substances that are capable of
sorbing some quantities of
apparently dry state.
Thus, oils or oil-drug solutions
incorporated into a powder
mixture which is granulated
& compacted into tablets.
fluids in an
can be
e.g. Microcrystalline cellulose
& silica.
48. • Give the tablet a more pleasant taste or to
mask an unpleasant one.
• Flavouring agents are often thermolabile
and so cannot be added prior
operation involving heat.
to an
• They are often mixed with the
granules as an alcohol solution.
49. • It is added to tablets to aid
and patient compliance.
identification
• It is added during coating.
• It can also be added prior to
compaction. (can be added as an
Insoluble powder or dissolved in the
granulation liquid).
50. • They are used in chewable tablet to exclude
limit the use of sugar in the tablets.
or
e.g. Mannitol, 72% as sweet as sucrose.
Saccharin, 500 times sweeter than
sucrose. Disadv.: has a bitter taste after
and carcinogenic.
time
Aspartame, Largely replace saccharin.
Disadv.: Lack of stability in the
presence of moisture.
51.
52. The Tablet Manufacturing Process
• The tablet manufacturing process is the step
by step, individual operations required to
make powders into a tablet.
This is known as individual units of operation;
or commonly referred to as
Unit Operations.
Weighing, Blending and Tableting
are unit operations in the tablet
manufacturing process.
•
•
53. The Tablet Manufacturing Process
• Powders must Flow and Compress in order to
make a good tablet.
We may need to add many unit operations to
make the powders perform.
•
• Each different formula may have a
different number of unit operations,
which is based completely on the
ability to Flow and Compress and
then eject from the tablet press.
54. •
•
•
Tablets are prepared either
Pre-granulation.
Direct compression
by:
• Granulation:
– Wet granulation
– Dry granulation
55. Reasons for granulating powders before
Tabletting:
Increase the bulk density of the powder.
Improve powder’s flowability, i.e. uniform
die feed.
Reduce segregation .
Improve powder’s compactability
1.
2.
3.
4.
by adding a solution binder.
5. Avoid the hazard of generation of
toxic dust.
Avoid caking of hygroscopic
powder on storage.
6.
56. Segregation
Segregation (demixing) is due to:
Differences in size.
Differences in density of the components of the
N.B.The smaller &/or denser particles at the base of the
•
1.
2. mix.
container & larger &/or less dense ones above them.
57. • Ideal granulation : each granule will
contain all the constituents of the mix.
in the correct proportion.
It is important to control particle size
distribution of the granules,
why???
•
58. Granulation overview
A process of size enlarging a mix of active
ingredient and excipient powder particles
•
into
stable aggregates
properties of:
Compressibility
Cohesiveness
Flowability
Bulk density
exhibiting desired
•
•
•
•
• Granules may be a final product
or an intermediate product that
needs further processing
59. Primary powder
particles
adhere
Granules
(larger free flowing multiparticles)
• Granules size 0.2 - 4 mm (depending on the use)
• Intermediate product • Larger granules
(When used as a Dosage form)
(In tablets & capsules
production) typical size
is 0.2-0.5mm.
60. Granulation Steps
- Initial dry mixing of powdered
ingredients
distribution
through the
(to
of
mix.).
achieve uniform
each ingredient
- Granulation.
- Mixing with other
tablet compaction
excipients prior to
or capsule filling).
61.
62. WET GRANULATION
It involves massing of a mix of dry
primary powder particles using a
granulating fluid.
The fluid contain a solvent that must
volatile and non-toxic e.g water,
ethanol.
•
• be
• The granulating solvent may contain a
binding agent to ensure particle
adhesion after drying.
63. Tablet Production via Wet Granulation:
Process description:
• Agitation of a powder by convection in the
presence of a liquid.
• It forms the granules by binding the powders
together with an adhesive.
•Once the granulating liquid has been
added, mixing continues until uniform
dispersion is attained (15 min. to an hour).
64. The mass should merely (just) become
moist rather than wet or pasty (there is a
limit to the amount of solvent that may be
employed).
Overly wet material would block the
screens & prolong the drying
processing.
End point is tested by pressing
a portion of the mass in the
palm, if it crumbles (passed)
under moderate pressure then,
the mixture is ready for wet
screening.
•
-
65. • The moist mass is broken up into coarse,
granular aggregates (using screens with large
perforations).
• The purpose is to increase surface area
facilitate removal of moisture.
Sreening the dry granules
Mixing with other tablet excipients
(lubricant, glidant, remaining of
disintegrant) and then compaction.
to
•
•
68. Drying process
• A process of evaporating the liquid
contained within aggregates
produced by a wet granulation
process to a predetermined moisture
content
Accomplished via direct (tray dryer)
or indirect (fluidized bed dryer)
contact of the product with the
heating medium
•
71. Single Step Technology for Wet
Granulation
wet granulation and drying process in
one unit operation.
Use Fluid Bed Dryer (FBD)
It is a multiple step process performed
in the same vessel to mix, granulate
and dry the powders.
Combines wetting the powders to
• Single machines utilized for both the
•
•
•
form granules &then, drying them in
the same piece of equipment.
72. Advantages of FBD
•
•
Reduced product handling
Closed process suitable to:
�
�
Potent compounds
Minimizing product/operator
exposure
Minimizing cross contamination
product loss
Reduced cleaning and overall
process time
� and
�
• Reduced equipment and floor space
requirements
73. FBD
• Powder bed is fluidized
for dry mixing and is
wetted with an
agglomeration solution
introduction as a fine
mist.
• The agglomerated
material remains
fluidized during hot air
drying
74. Spray Drying
Best granules, regarding homogeneity,
•
flowability and compactability.
• The tablet components are suspended
/or dissolved in a suitable vehicle
according
to their nature.
The slurry is pumped to an atomizing
wheel which whirls the material into a
stream of hot air Under constant stirring
to maintain good distribution.
The heat removes the liquid carrier and
the solids fall to the bottom of the dryer
as a fine spherical granulate (10 – 250
µm).
•
•
77. Tablet Produced by Compression
Granulation (Dry Granulation):
• Advantage:
(1) Avoid exposure of
moisture and heat.
the powder to
(2) Used for powders of very low
bulk density to ↑ their bulk density.
• Disadvantages:
– Tablet disintegration and dissolution
may be retarded due to double
lubrication and compaction
78. Steps of Dry Granulation:
• The blend of finely divided powders is
forced into the dies of a large capacity
tablet press.
Then, compacted by means of flat faced
punches (Compacted masses are called slugs
and the process is slugging) or roll
compactor to produce sticks or
sheets.
Slugs or sheets are then milled/screened
to produce granules (flow more than
the original powder mixture).
•
•
80. (solvent)
sieve
T
o produce a
drying
between 2
heavy duty
produce a
press
particles.
Dry granulation Wet granulation
Primary powder particles
aggregated under high
pressure.
Slugging Roller
compaction
large tablet Powder is
(slug) in a squeezed
tabletting rollers to
sheet of
material
Intermediate product
Mix of dry primary powder particles
Granulating fluid
Wet mass
Forced through a
Wet granules
Dry granules
Screening stage
Break agglomerates of
granules & remove fine
81. by drying.
Typical liquids include:
stability, causing hydrolysis ,it
process. The advantage :non-
used with water sensitive drugs
Intermediate product
broken
(suitable
milling
technique)
Granular material
sieved
Separate the
desired size
fraction.
• The fluid contains a solvent, which
must be :
1. volatile so that it can be removed
2. be non-toxic.
1. water : may adversely affect drug
needs a longer drying time. This
increases the length of the
flammable and economic.
2. Ethanol, Isopropanol ,or
combination (organic solvents)
,alternative to dry granulation or
when rapid drying time is
required.
82.
83. • It involves only two unite operations
powder mixing and tabletting.
•
1.
2.
Advantages of Direct Compaction:
Reduced production time &cost.
Product stability can
be improved.
Faster drug dissolution due to fast
disintegration into primary particles.
3.
84. Disadvantages of Direct Compaction:
1. Large particles must be used → (acceptable
flowability and bulk density)
2. If the drug powder has low compactabilty,
difficult to form into tablets.
it is
3. Needs directly compressible filler that
is usually expensive, e.g. microcrystalline
cellulose (Avicel), spray dried lactose.
85. •
1.
Drugs used in Direct Compaction:
Soluble drugs which can be processed as
coarse particles (to ensure good flowability).
Potent drugs which are present in a few
mgs in each tablet (mixed with relatively
coarse excipient particles).
2.
86. Steps of Tablet Production by Direct
Compaction:
+
- Drug
- Filler
• Dry binder
• Disintegrant
• Lubricant
Mixing
Tableting
87. N.B.
Every granulation should start with
materials that have been ground to the
same approximate particle size, so that
they will blend uniformly in the mixing
step.
89. 1. Binding:
It is the adhesion of the granules to the die wall
and this cause the resistance of the tablet to
eject from the die, it is usually due to insufficient
lubrication, which produce tablets with
and vertical score marks on the edges.
rough
•
•
•
Solution:
1.
2.
3.
Increasing lubrication.
Improve lubricant distribution.
Increasing the moisture content
of the granulation.
90. 2. Sticking, Picking & Filming:
Adhesion of the material to the punch faces.
Sticking : (whole adhesion)
•
Is usually due to improperly(incorrectly) dried or
lubricated granulation causing the whole tablet
surface to stick to the punch faces → dull,
scratched, or rough tablet faces.
• Picking : (localized adhesion)
Is a form of sticking in which a small
portion of granulation sticks to
the punch face & a portion of the
tablet surface is missed.
93. Filming: is a slow form of sticking and is largely
due to excess moisture in the granulation.
94. 3. Capping & Laminating:
Capping occurs when the upper
segment of the tablet separates from the
main portion of the tablet & comes
a cap.
It is usually due to air entrapped
in the granulation which is
compressed in the die during the
compression & then expands
when the pressure is released.
off as
•
95.
96. • Reasons of capping : 1. large amount of fines in
the granulation &/or the lack of sufficient
clearance between the punch and the die wall.
In new punches and dies that are tight fitting.
2.
3. Too much or too little lubricant
moisture.
or excessive
Lamination is due to the same
causes as capping except that
the tablet splits at the sides into
two or more parts.
If tablets laminate only at certain
stations, the tooling is usually the cause.
97. • Solutions for capping & laminating:
1.
2.
Increasing the binder.
Adding dry binder such as gum acacia
PVP or powdered sugar.
Decreasing the upper punch
diameter.
,
3.
98. 4. Mottling:
It is an unequal distribution of color on the surface
of the tablet.
99. • Cause : 1. A drug that differs in color from its
excipients or whose degradation products
are highly colored.
2. Migration of a dye during drying
of a granulation (change the solvent
system, reduce the drying temperature,
or grind to a smaller particle size).
100. • Tablets can be classified according to
0
their drug-release characteristics into:
Tablets Types
101. Immediate-release tablets
The drug is intended to be released rapidly
after administration, or the tablet is
dissolved and administered as a solution.
This is the most common type of tablet
includes disintegrating, chewable,
effervescent, sublingual & buccal
tablets.
Modified-release tablets
&
- Should normally be swallowed intact.
- Different excipients than
immediate release tablets.
102. The drug is released from an extended-release
tablet slowly at a nearly constant rate.
Delayed-release tablets
The drug is liberated from the tablet some time
after administration.
After this period has elapsed, the release
normally rapid.
e.g. Enteric tablet, for which the drug is
released in the upper part of
the small intestine after the
preparation has passed the stomach.
is
103. A delayed-release can also be
combined with a slow drug release, e.g.
of
for local treatment in the lower
colon.
part
the intestine or in the
105. 1. Disintegrating tablets
Most common type is intended to be
swallowed and release the drug in a relatively
short time after disintegration and dissolution
thus fast & complete drug release in vivo
(conventional or plain tablets).
A disintegrating tablets include the following
•
•
types of excipients: filler (if the dose of drug
low), disintegrant, binder, glidant, lubricant
and antiadherent.
is
Steps of drug release from disintegrating tablets
Tablet
disintegration
Drug
dissolution
Drug
absorption
106. 2. Chewable tablets
They are chewed so mechanically disintegrated in the
mouth.
The drug is not dissolved in the mouth but swallowed
and dissolves in the stomach or intestine.
•
•
Uses of chewable tablets:
1. Quick and complete disintegration of the tablet - and
hence obtain a rapid drug effect e.g. antacid tablets.
2. Facilitate the intake of the tablet for elderly and
children who have difficulty in swallowing e.g. vitamin
tablets.
Can be taken when water is not available.
3.
They are similar in composition to conventional tablets
except that a disintegrant is normally not included.
107. 3. Effervescent tablets
Effervescent tablets are dropped into a glass of water
before administration,
liberated.
during which carbon dioxide is
facilitates tablet
disintegration and drug
dissolution; the dissolution
of the tablet should be
complete within a few
minutes.
Carbonate
or
Bicarbonate
Weak acid
(citric) CO2
108. Uses of effervescent tablets:
1. Rapid drug action, e.g. analgesic drugs .
2. Facilitate the intake of the drug, e.g. vitamins.
temporarily
increases the pH
of the stomach.
rapid emptying
of the stomach
and shortening
the residence
time
Dissolution of
tablets
buffered
solution
water
fast drug bioavailability
(As drugs are absorbed
more effectively in the
small intestine than
stomach) e.g.
analgesics
in the
Drug-induced gastric irritation can
be avoided (due to short residence
time) e.g. aspirin tablets
109. Effervescent tablets
contain
usually
colourant
A water-soluble
lubricant is
preferable in
order to avoid
a film of a
hydrophobic
lubricant on
the surface of
the water after
tablet
dissolution.
disintegrant are
included in the
N.B. binder and
normally not
composition
Flavor and a
Carbonate or
bicarbonate and
a weak acid such
as citric or tartaric.
The amount of
sodium
bicarbonate in an
effervescent
tablet is often
quite high (about
1 g )
110. Effervescent tablets
by:
are prepared
Compaction via
granulation;
Direct compaction
traditional
granulation
used.
wet
is rarely
Effervescent tablets
packaging:
They must be protected against moisture by using
waterproof containers, often including blister packs
aluminium foils, otherwise it will be self destructed.
or
111.
112. 4. Lozenges
• They are tablets that dissolve slowly in the
mouth and so release the drug dissolved in
the saliva.
They can thus be described as slow-release
tablets for local drug treatment.
•
Use of lozenges:
Local medication in the mouth or
common cold, to treat cough by
1.local anesthesia,
2.antiseptic
3.antibiotic drugs.
throat in
113. Lozenges are usually contain:
They are similar in composition to conventional
tablets.
Disintegrants are not used.
Colour and flavour.
High concentration of Fillers which are mainly sugars,
such as glucose, sorbitol or mannitol.
High concentration of binder; e.g. gelatin.
Lozenges are prepared by
1.
2.
3.
4.
5.
Compaction at high applied pressures in order to
obtain a tablet of high mechanical strength and low
porosity which can dissolve slowly in the mouth.
114. 5. Sublingual and buccal tablets
Used for drug release in the mouth followed
by systemic uptake of the drug.
Rapid systemic drug effect can thus be
obtained without first-pass liver metabolism.
Sublingual tablets are placed under the
tongue and buccal tablets are placed in
the side of the cheek.
They are often small and porous, the latter
facilitating fast disintegration and drug
release.
•
•
•
•
115. 6. Soluble tablets
• Soluble tablets are uncoated
film-coated tablets. They are
or
intended to be dissolved in
water before administration. The
solution produced may be
slightly opalescent due to the
added excipients used in the
manufacture of the tablets.
116.
117. • This test may be official or unofficial.
•
1.
3.
Official tests are:
Weight variation 2. Content uniformity
Dissolution. 4. Disintegration.
•
1.
2.
Non official
Friability .
Hardness.
tests are:
3.Thickness .
118. 1.
•
Weight Variation:
Collecting a sample of tablets(normally 20)
and determining their individual weights.
• The average weight of the tablets is
calculated.
The sample complies with the
standard if the individual weights
don’t deviate from the mean more
than is permitted in terms of
percentage.
then
•
120. • If the drug forms the greater part
of the tablet mass, any weight
variation reflects variations in the
content of active ingredients.
• In case of potent drugs, the
excipients from the greatest part
of the tablet weight & so the
correlation between tablet
weight and amount of active
ingredient can be poor.
121. • What is the significance of the
weight variation test????
• If tablet batch not pass the test,
what processing factors are the
cause for such Failure?? And
what is the possible solution????
122. Causes of Weight Variation:
1. The size & distribution of the granules being
compressed (presence of too large or too fine
granules).
2.
3.
Poor flow (cause incomplete filling of the die).
glidants
Poor mixing. (Sometimes the lubricants
have not been well distributed).
When lower punches are of
unequal lengths the fill of each
die varies because the fill is volumetric.
Solution: (Only a good punch & die
control program can provide tooling
&
4.
of uniform dimensions). Change lubricate
glidant.
and/or
123. 2. Content Uniformity:
• Determining the
tablets (10 ).
amount of drug in a sample of
•
•
The average drug content is calculated.
The content of the individual
tablets should fall within
specified limits in terms of % deviation
from the mean (85 – 115%). If not comply
repeat using 20 more tablets.
No one should be 75 – 125% deviation
Causes: ???
Solution: ????
124. 3. Disintegration:
The test is carried out by:
• Agitating a given number of tablets in an aqueous
medium at a defined temperature & the time to
reach the end-point of the test is recorded.
• The end-point of the test is the
point which all visible parts of the tablets
have been eliminated from tubes in which
the tablets has been held during agitation.
• The preparation complies with
the test if the time to reach this
end-point is below given limit; 15-30 minutes
uncoated immediate release tablets.
for
127. •
•
Special cases
Effervescent tablets
• Place 1 tablet in a beaker
containing 200 ml of water at 25°C;
the tablet should evolve bubbles
and disintegrate within 5 minutes,
use 6 tablets
Soluble tablets
•
• Soluble tablets disintegrate within 3
min when placed in water at 25°C.
129. • What is the significance of
the disintegration test???
• If tablet batch not pass the
test, what processing
factors are the cause for
such failure?? And what is
the possible solution???
130. 4. Dissolution:
• It is an important tool to assess
factors that affect the
bioavailability of a drug from
a solid preparation.
131. • Dissolution tests are carried out for several
reasons :
1. To evaluate the possible effect of
formulation & process variables
bioavailability of a drug.
on the
2. To indicate the performance
of the preparation under in vivo
conditions.
132. •
•
The Dissolution test:
To study the cumulative amount of drug
that passes into solution as a function of
time.
Locate the tablet in a chamber
containing a flowing dissolution medium.
All factors that can affect the dissolution
process must be standardized.
This includes factors that affect
the solubility of the substance
(i.e. the composition, rotation &temperature of
the dissolution medium)
•
•
133. • Dissolution tests can be classified
two main groups:
Stirred-vessel methods.
Continuous-flow methods.
into
1.
2.
• The most important Stirred
methods are:
Vessel
1.
2.
Rotating-basket method (Apparatus I).
Paddle method (Apparatus II).
135. Paddle
Method
Rotating Basket
Method
Both use the same type of vessel, which is filled
with a dissolution medium of controlled volume
and temperature.
The tablet is placed in
the vessel & the
dissolution medium is
agitated by a rotating
paddle.
The tablet is placed in a
small basket formed
from a screen. This is
then immersed in the
dissolution medium
& rotated at a given
speed.
139. • The amount of drug dissolved within a
certain time period is determined by
taking samples from the dissolution
medium and analyzed after specified
time intervals.
Limit: 75% of the drug should be dissolved
within 30 minutes, unless otherwise
specified by the manufacturer.
•
141. 1. Hardness (Fracture-resistance test):
Tablets require a certain amount of
strength or hardness. Why?
1. Withstand mechanical shocks of
handling in manufacture, packaging
and shipping.
2. Withstand reasonable abuse
when in the hands of the consumer.
3. The relationship of hardness
to tablet disintegration, dissolution .
142. • Tablet Hardness: The force required to break a
tablet along its diameter by applying compression
loading.
•
A
Test Description:
tablet is placed between two anvils,
force is applied to the anvils, & the
crushing strength that just causes
the tablet to break is recorded (in kg).
Hence, Hardness is thus sometimes
termed the tablet crushing strength.
- Tablet hardness should be between
6 – 10 kg
143.
144. . Hardness Variation:
• It depends on:
- compression force,
- concentration and type of binding agent
If the tablet initially is too hard, it may not
•
disintegrate in the requisite period of time.
• If it is too soft, it may not withstand
the necessary multiple shocks
occurring during handling,
shipping, and dispensing.
• N.B. Hardness generally increase with
normal storage of tablets.
145. 2. Friability (attrition-resistance test):
It's another measure of a tablet's strength.
Why measure friability?
Tablets that tend to powder, chip &
fragment when handled:
lack elegance & consumer acceptance,
Create excessively dirty
processes in areas of manufacturing as
coating & packaging.
Can also add to a tablet's weight
variation or content uniformity problems.
1.
2.
3.
146. • The laboratory friability tester is known as the
Roche friabilator.
• It subjects a number of tablets to the
combined effects of abrasion & shock by
utilizing a plastic chamber that revolves
rpm, dropping the tablets with each
revolution.
at 25
• A preweighed tablet sample is
placed in the friabilator, which is
then operated for 100 revolutions.
150. • Tablets are then dusted and reweighed.
• Conventional compressed tablets that
lose less than 1.0% of their weight are
generally considered acceptable.
• % friability = (W0 – Wf / W0) x %.
W0 = initial weight.
Wf = final weight.
151. 3. Tablet's Thickness:
• Thickness can vary with no change in
weight due to difference in the density of
to
the
the
granulation & the pressure applied
tablets.
• If the tablets are thicker than
specified, a given number no longer
may be contained in the volume
of a given size bottle.
153. What is the rationale for coating a solid
dosage form?
Therapy
• To minimise irritation of the oesophagus and stomach.
• Minimise inactivation in the stomach.
• Improve drug effectiveness.
• Improve patient compliance e.g. easier to swallow,
masks unpleasant taste.
154. What is the rationale for coating a
dosage form?
Technology
solid
• Minimise
to tablets.
dust formation and contamination with respect
• Masks batch differences in the appearance of raw
materials.
• Facilitates their handling on high speed automated filling
and packaging equipment.
• Improves drug stability e.g. Protection of active ingredient
from environment such as sunlight, moisture.
155. What is the rationale for coating
dosage form?
Marketing
a solid
• Aid sales appeal as improved
appearance and acceptability with
respect to gloss and colouration.
• Mask unpleasant taste.
• Improve product identity.
156. Definition
• Coated tablets are defined as
or
of
tablets
more
various
covered with one
layers of mixture
with
substances the
intention of (adding) conferring
benefits
dosage
and properties to the
the
form over
uncoated one.
159. Sugar coating
• Traditionally sugar coatings formed the bulk of coated tablets but today
film coatings are the more modern technology in tablet coating.
Description of tablets: Smooth, rounded and polished to a high gloss.
Process: Multistage process involving 6 separate operations.
•
•
1.
2.
3.
4.
5.
6.
Seal tablet core
Sub coating
Smoothing
Colouring
Polishing
Printing
160. Multistage process
Sealing tablet core- application of a water impermeable
polymer such as Shellac, cellulose acetate phthalate and
polyvinyl acetate phthalate, which protects the core from
moisture, increasing its shelf life.
1.
Sub coating -by adding bulking agents such as calcium
carbonate or talc in combination with sucrose solution.
2.
Smoothing process -remove rough layers formed in step
2 with the application of sucrose syrup.
3.
161. Multistage process
Colouring - for aesthetic purposes often
pigments are included.
4. titanium based
5. Polishing - effectively polished to give characteristic
shine, commonly using beeswax, carnauba wax.
Printing -permanent ink for characterization.
6.
163. Example of sugar coated tablets
Brufen® POM
– Available in 200mg and
400mg strength
Premarin® POM
– Conjugated oestrogens
625mcg (maroon) and
1.25mcg (yellow)
Colofac ® P
– Mebeverine hydrochloride
100mg Round, white,
sugar coated
164. Simplified representation of
coating process
sugar
Spraying Wetting/distribution Recrystallisation Sugar coated particle
Particle
Coating droplets
Layer build-up
165. • Ideal properties of sugar coating
-
-
-
Perfect smooth rounded
Even colour coverage
Polish to high gloss
countour
•
•
Coating faults
Coat splitting caused by
coat during application
inadequate drying of
166. Film coating
• Modern approach to coating tablets, capsules, or pellets by
surrounding them with a thin layer of polymeric material.
• Description of tablets: Shape dictated by contour of original core.
• Process: Single stage process, which involves spraying a coating
solution containing the following;
Polymer
Solvent
Plasticizer
Colourant
1.
2.
3.
4.
The solution is sprayed onto a rotating tablet bed followed
by drying, which facilitates the removal of the solvent
leaving behind the deposition of thin film of coating
materials around each tablet.
167. Film coating
Advantages
Produce tablets in a single step
process
time.
in relatively short period of
Process enables functional
coatings to be incorporated into the
dosage form.
Disadvantages
There are environmental and safety
implications of using organic solvents
as well as their financial expense.
169. The vast majority of film coated tablets are produced by a process
which involves spraying of the coating material onto a bed of tablets.
Accela Cota is one example of equipment used for film coating.
Accela Cota
171. Mechanism of Film Formation
latex particles dispersed
in liquid vehicle
formation of thin film with
water evaporation through film
continuous film
172. Polymer used in film
Examples;
coating
• Cellulose derivatives;
Hydroxypropyl
methylcellulose (HPMC),
HPC, water soluble
- Ethylcellulose is water
insoluble
Methacrylate amino ester
copolymers;
- pH selective polymer
MC,
•
173. Plasticizer used in film coating
-
-
•
Reduce film brittleness
Examples;
Polyols
400
- Polyethylene glycol
• Oils/glycerides
coconut
oil
- fractional
174. Colourants
Examples;
used in film coating
•
•
•
Iron oxide pigments
Titanium dioxide
Aluminium lakes.
Water insoluble pigments are more favourable than
water soluble colours for the following reasons;
Better chemically stability in light
Optimised impermeability to water vapour
Better opacity
Better covering ability
175. Solvents
Traditionally, organic solvents had been used to
dissolve the polymer but modern techniques rely on
water because of significant drawbacks. Below lists
some of the problems associated with organic
solvents.
•
•
•
•
Environmental
Safety
Financial
Solvent residues
178. Solvents
Financial
The hazards associated with
organic solvents necessitates the
need for building
proof
flame- and
explosive-
addition,
facilities. In
the cost of their
are
storage
relatively
and ingredients
expensive.
180. Ideal characteristics of film-coated tablets
• Even coverage of film and
colour,
No abrasion of tablet edges,
Logos and break lines should
distinct and not filled,
•
• be
• Comply with the pharmacopeial
requirement.
181. Problems of Film Coating
• picking/chipping
• roughness
• sticking
• film cracking/peeling
182. Why is film coating favoured over
sugar coating ?
Sugar coating
Tablet appearance
Film coating
Tablet appearance
Rounded with high degree of
polish
Larger weight increase 30-50%
due to coating material
Retains shape of original core
Small weight increase of 2-3%
due to coating material
logo or ‘break lines’ possible
Logo or ‘break lines’
impossible
Process
are
Process
Can be
Cota
automated e.g. Accela Difficult to automated e.g.
traditional coating pan
Easy training operation
Single stage process
Easily adaptable for controlled
Considerable training operation
Multistage process
Not able to be used for controlled
release apart from enteric coating.
release allows for
coatings.
functional
183. Press coating
Press coating process involves compaction of coating material around a preformed
core. The technique differs from sugar and film coating process.
Advantages
This coating process enables incompatible materials to be formulated together, such
that one chemical or more is placed in the core and the other (s) in the coating
material.
Disadvantages
Formulation and processing of the coating layer requires some care and
complexities of the mechanism used in the compressing equipment.
relative
184. Functional coatings
Functional coatings are coatings, which perform a
pharmaceutical function.
These include;
Enteric coating
•
• Controlled release coating
185. Enteric coating
The technique involved in enteric coating is protection of the
tablet core from disintegration in the acidic environment of the
stomach by employing pH sensitive polymer, which swell or
solubilize in response to an increase in pH to release the drug.
Aims of Enteric protection:
Protection of active ingredients, from
the stomach.
the acidic environment of
Protection from local irritation of the stomach mucosa.
Release of active ingredient in specific target area within
gastrointestinal tract.
186. •
Enteric coating
An enteric coating is a barrier
applied to oral medication
controls the location in the
digestive system where it is
absorbed.
Enteric refers to the small
intestine, therefore enteric
coatings prevent release of
that
•
medication before it reaches
the small intestine.
used for drugs that are
unstable, irritating to stomach
•
187. Examples of enteric coated OTC products
• Enteric coated aspirin E.g.
Micropirin® 75mg EC
tablets
• Enteric coated peppermint
oil E.g. Colpermin®
188. Summary of Polymers used in pharmaceutical formulations
as coating materials.
targeting to distal small
Sustained Release Coatings
Polymer Trade name Application
Shellac EmCoat 120 N
Marcoat 125
Enteric Coatings, pH 7
intestine
Cellulose acetate
phthalate
Aquacoat CPD®
Aquacoat® ECD
Enteric Coatings
Sustained release coating
Sub coat moisture and
barrier sealant pellet coating
Polyvinylacetate
phthalate
Sureteric® Enteric Coatings
Methacrylate Eudragit® Enteric Coatings
Rapidly disintegrating Films
189. Film coating of Beads
spheres
and
• Fluid bed dryer is used