intro&suzuki.pptx
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The document discusses four reaction types: Suzuki, Heck, Sonogashira, and Biginelli reactions. The Suzuki, Heck, and Sonogashira reactions are classified as cross-coupling reactions that are palladium-catalyzed and base-catalyzed. They are used to create C-C bonds. The Suzuki reaction specifically involves an organohalide and organoboron reactant with a palladium catalyst and base to form a coupled C-C product. The Biginelli reaction is a one-pot, three component cyclocondensation reaction that is acid-catalyzed.
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Suzuki Reaction.pptx
Suzuki Reaction and its Mechanism, Akira Suzuki, Trans metalation, Reductive Elimination, Merits, Green synthesis
Suzuki reaction
The Suzuki reaction is a palladium-catalyzed cross-coupling reaction between boronic acids or esters with organic halides, triflates, or other boron-containing compounds. This reaction occurs under basic conditions and leads to the formation of carbon-carbon single bonds, typically between an aryl or vinyl group and another aryl or vinyl group. It is commonly used to synthesize biaryl compounds. The reaction proceeds through oxidative addition, transmetallation, and reductive elimination steps. Key advantages are mild reaction conditions and availability of boronic acids. The Suzuki reaction has applications in synthesizing pharmaceuticals, agrochemicals, and natural products.
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The Suzuki-Shapiro reaction, also known as the Suzuki coupling, is a widely used organic reaction for the formation of carbon-carbon bonds between aryl or vinyl halides and boronic acids or boronate esters. It was discovered independently by Akira Suzuki and Barry Shapiro in the 1970s and has since become a versatile and valuable tool for synthesizing a variety of organic compounds, including natural products, pharmaceuticals, and materials.
The Suzuki-Shapiro reaction involves the use of a palladium catalyst, typically a palladium complex with a phosphine ligand, in the presence of a base, such as potassium carbonate, and a solvent, such as an ether or DMF. The reaction proceeds through a series of steps, including oxidative addition of the aryl or vinyl halide to the palladium catalyst, transmetallation with the boronic acid or boronate ester, and reductive elimination to form the desired carbon-carbon bond.
One of the advantages of the Suzuki-Shapiro reaction is its broad substrate scope, including aryl and vinyl halides of different electronic and steric properties, as well as boronic acids and boronate esters with various functional groups. The reaction is also tolerant of a wide range of reaction conditions, making it compatible with a variety of reaction setups and scales.
The Suzuki-Shapiro reaction has many applications in organic synthesis, including the preparation of conjugated polymers, biaryl compounds, and natural product derivatives. It has also been used in the synthesis of drugs, such as the anticancer agent bortezomib, and in the development of new materials, such as OLEDs and semiconductors.
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Suzuki reaction
The Suzuki reaction is a palladium-catalyzed cross-coupling reaction between boronic acids or esters with organic halides, triflates, or other boron-containing compounds. This reaction occurs under basic conditions and leads to the formation of carbon-carbon single bonds, typically between an aryl or vinyl group and another aryl or vinyl group. It is commonly used to synthesize biaryl compounds. The reaction proceeds through oxidative addition, transmetallation, and reductive elimination steps. Key advantages are mild reaction conditions and availability of boronic acids. The Suzuki reaction has applications in synthesizing pharmaceuticals, agrochemicals, and natural products.
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The Suzuki-Shapiro reaction, also known as the Suzuki coupling, is a widely used organic reaction for the formation of carbon-carbon bonds between aryl or vinyl halides and boronic acids or boronate esters. It was discovered independently by Akira Suzuki and Barry Shapiro in the 1970s and has since become a versatile and valuable tool for synthesizing a variety of organic compounds, including natural products, pharmaceuticals, and materials.
The Suzuki-Shapiro reaction involves the use of a palladium catalyst, typically a palladium complex with a phosphine ligand, in the presence of a base, such as potassium carbonate, and a solvent, such as an ether or DMF. The reaction proceeds through a series of steps, including oxidative addition of the aryl or vinyl halide to the palladium catalyst, transmetallation with the boronic acid or boronate ester, and reductive elimination to form the desired carbon-carbon bond.
One of the advantages of the Suzuki-Shapiro reaction is its broad substrate scope, including aryl and vinyl halides of different electronic and steric properties, as well as boronic acids and boronate esters with various functional groups. The reaction is also tolerant of a wide range of reaction conditions, making it compatible with a variety of reaction setups and scales.
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- 1. Suzuki, Heck, Sonogashira and Biginelli Reactions Presented by Mai Samir Lotfy Under Supervision of Prof. Dr. Fathy Abdelrazek
- 2. Introduction In this part we will study 4 types of reactions. Suzuki, Heck, Sonogashira and Biginelli reactions. Suzuki, Heck and Sonogashira reactions are classified as: • Cross-Coupling Reactions. • Palladium Catalyzed Reactions. • Base Catalyzed Reactions. Biginelli Reaction is classified as: • Cyclocondensation Reaction. • Acid Catalyzed Reaction. •One-pot, three components reaction (Multicomponent Reaction).
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