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1. ADVANCEMENT ON SUSTAIN
TYPE OF DRUG DELIVERY SYSTEM
Presented by:-
Bhupendra M. Mahale
Yogesh S. Mali
Varsha Girase.
Guided by:-
Mr. Arvind Pawara.
(Assistant Professor)

2. Contents
❖ Introduction
❖ Rational in designing S.R.D.F
❖ Concept of S.R.D.F
 Repeated action Vs sustained
action drug therapy
❖ Merit
❖ Demerit
❖ Marketed product
❖ References

3. Datta Prabhu
CFS
INTRODUCTION

4. WHAT IS DRUG DELIVERY
SYSTEM…
?

5. The term “Drug Delivery Systems” refers to the technology to the
utilized to present the drug to the desired body site for drug release and
absorption.

6. SLEEKPRESENTATION
An ideal dosage regimen would be one, in which the concentration
of the drug, nearly coinciding with minimum effective concentration
(M.E.C), is maintained at constant level throughout treatment period
such situation can be graphically represented.

7. What is Sustain Release
Dosage Form…………..?

8. “Drug Delivery System that are designed to achieve
Prolonged therapeutic effect by continuously releasing
medication Over an extended period of time
after administration of single dose.”
The basic goal of therapy is to achieve steady state blood level that is
therapeutically effective and non toxic for an extended period of time.
The design of proper dosage regimen is an important element in
accomplishing this goal.

9. Rationales in designing S.R.D.F
The basic objective in dosage form design is to Optimize the delivery of
medication to achieve the control of therapeutic effect in the face of
uncertain fluctuation in the vivo environment in which drug release take
place.
The is usually concerned with maximum drug availability by attempting
to attain a maximum rate and extend of drug absorption how ever, control of
drug action through formulation also implies controlling bioavailability to
reduce drug absorption rate

10. Plasma Concentration v/s Time Curve

11. ❖ Repeat-action Versus Sustained- action drug therapy
A repeat- action tablet may be distinguished from its sustained-product
by the release of the drug in slow controlled manner and consequently
does not give a plasma concentration time curve which resemble that of
a sustained release product.
A repeat action tablet usually contains two dose of drug; the 1st being
released immediately following oral administration in order to provide a repeat
onset of therapeutic response. The release of Second dose is delayed,usually by
means of an enteric coat.
Consequently ,when the enteric coat surrounding the second dose is
breached by the intestinal fluid, the second dose is release immediately

13. Merits
➢ Improve patient convenience and compliance due to less frequent drug
administration.
➢ Reduction in fluctuation in steady-state level and therefore better control of
disease condition.
➢ Increased safety margin of high potency drug due to better control of plasma
levels.
➢ Maximum utilization of drug enabling reduction in total amount of dose
administered.
➢ Reduction in health care cost through improved therapy,shorter treatment
period.

14. ● Decreased systemic availability in comparison to immediate release
conventional dosage form; this may be due to incomplete release, increased
first-pass metabolism, increased instability, insufficient residence time for
complete release, site specific absorption , pH dependent solubility etc.
● Poor in-vivo, in-vitro correlation.
● possibility of dose dumping due to food , physiologic or formulation variable or
chewing or grinding of oral formulation by the patient and thus increased risk of
toxicity.
● Economics factors must also be assessed, since more Costly processes and
equipment are involved in manufacturing many sustained release form.
Demerits...

15. Composition Product Name Manufacturer Product
Carbamazepine
(Tablet)
Zen Retard Intas
Omeprazole
( Capsule)
Omesec Ranbaxy
Nitro-glycerine
(Transdermal)
Nitorderm TTS Ciba-Geigy

16.  Leon Lachman – The theory and practice of industrial pharmacy .
 Michael E Alton – Pharmaceutics The science of Dosage form design
 Bramhankar – Text Book of Bio pharmaceutics & Pharmacokinetics
 FORMULATION Sustained Release Coatings By Nigel
Langely,PHD,MBA,and Yidan Lan Issue date June 2009

17. Thank You
For Your Attention
JAYHIND