This document discusses stress urinary incontinence (SUI), including its definition, prevalence, clinical testing, investigation, and classification systems. It then covers both conservative and surgical treatment options for SUI, with an emphasis on the various surgical procedures. Key points discussed include midurethral sling procedures being the current first-line surgical approach, with transobturator tapes preferred over retropubic or transvaginal needle suspensions. Factors in choosing the appropriate procedure include the presence of other pelvic organ prolapse and the severity of incontinence.
bladder pain syndrome is highly prevalent. it is a diagnosis of exclusion. the biggest hurdle in management is diagnosis. more often than not patients suffering with BPS move from pillar to post, from a clinician to another, often getting urethral dilatations, receiving NSAIDS and even antipsychotics (having been labelled as 'psychiatric' patient).
once diagnosis is made, treatment is multipronged and based on phenotype - the concept is called UPOINT. interstitial cystitis is a small but significant minority (moreover ulcerative type) of BPS.
Gabapentin, amitriptyline and pentosan polysulfate are cornerstone pharmacotherapeutic agents for IC/BPS
Classification & conservative surgeries for prolapseIndraneel Jadhav
Stage 0
no prolapse
- Aa,Ba,Ap,Bp are all at -3
- C or D between tvl and < tvl -2
Stage I
most distal portion > 1cm above level of hymen
Stage II
<1cm proximal to or distal to the plane of hymen
Stage III
>1cm below the plane of the hymen
Stage IV
complete eversion, distal portion at least (tvl -2 cm)
Urinary Tract Fistulas -(VVF) Etiology, Diagnosis, ManagementVikas V
Urinary Tract Fistulas - Etiology, Diagnosis, Management
Surgical and Relevant Anatomy, Classification, eitiology, VVF in Detail, Examination and Diagnosis, Management of VVF - Both Conservative And Surgical Management - Steps of Surgical Management, Post operative Management.
Urinary incontinence is defined as any involuntary or uncontrolled loss of urine sufficient to cause a social or hygienic problem.
Urge urinary or “urge”—incontinence is the involuntary leakage accompanied or immediately preceded by a perceived strong imminent need to void
bladder pain syndrome is highly prevalent. it is a diagnosis of exclusion. the biggest hurdle in management is diagnosis. more often than not patients suffering with BPS move from pillar to post, from a clinician to another, often getting urethral dilatations, receiving NSAIDS and even antipsychotics (having been labelled as 'psychiatric' patient).
once diagnosis is made, treatment is multipronged and based on phenotype - the concept is called UPOINT. interstitial cystitis is a small but significant minority (moreover ulcerative type) of BPS.
Gabapentin, amitriptyline and pentosan polysulfate are cornerstone pharmacotherapeutic agents for IC/BPS
Classification & conservative surgeries for prolapseIndraneel Jadhav
Stage 0
no prolapse
- Aa,Ba,Ap,Bp are all at -3
- C or D between tvl and < tvl -2
Stage I
most distal portion > 1cm above level of hymen
Stage II
<1cm proximal to or distal to the plane of hymen
Stage III
>1cm below the plane of the hymen
Stage IV
complete eversion, distal portion at least (tvl -2 cm)
Urinary Tract Fistulas -(VVF) Etiology, Diagnosis, ManagementVikas V
Urinary Tract Fistulas - Etiology, Diagnosis, Management
Surgical and Relevant Anatomy, Classification, eitiology, VVF in Detail, Examination and Diagnosis, Management of VVF - Both Conservative And Surgical Management - Steps of Surgical Management, Post operative Management.
Urinary incontinence is defined as any involuntary or uncontrolled loss of urine sufficient to cause a social or hygienic problem.
Urge urinary or “urge”—incontinence is the involuntary leakage accompanied or immediately preceded by a perceived strong imminent need to void
Most ovarian abnormalities can be managed laparoscopically. Ovarian pathology can occur at any time from fetal life to menopause. First laparoscopic salpingooophorectomy was performed by Semm in 1984.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2.
SUI is best defined by the International Continence
Society as “involuntary leakage of urine on exertion,
effort, coughing, or sneezing.
The majority of published data suggest that around
50% of incontinent women will exhibit pure SUI with
a further 30% experiencing mixed incontinence.
Thus potentially large numbers of adult women
with troublesome urine leakage will have a “stress
component” to their incontinence.
INTRODUCTION
4.
Urinary stress test
Cotton swab test
Post void residual volume
Perennial pad test
Urodynamic testing
Intrinsic sphincter deficiency test
Clinical testing
6.
Video urodynamic
Degree of urethral mobility
Function of the urinary sphincter
Weakness of the pelvic floor
Blaivas classification
7.
Type 0
the vesical neck and proximal urethra are closed at rest
being situated at or above the superior margin of the pubic
symphysis
During stress (cough or strain) although the vesical neck and
proximal urethra open
no leakage is observed.
Type 1
The vesical neck is closed at rest,
situated at or above the inferior margin of the pubic symphysis.
During stress maneuver with increased abdominal pressure, the
vesical neck and proximal urethra open and descend < 2 cm, with
urinary incontinence being demonstrated.
8.
Type 2a
The vesical neck is closed at rest
above the inferior margin of the pubic symphysis.
During stress, the vesical neck and proximal urethra descend >2
cm
urinary incontinence is demonstrated.
Type 2b
At rest, the vesical neck is closed
but is situated below the inferior margin of the pubic symphysis.
During stress, there is further descent, the proximal urethra opens
and urinary incontinence is demonstrated.
9.
Type 3
At rest, the vesical neck and proximal urethra are
open,
despite the absence of a detrusor contraction, there
is obvious leakage of urine,
which is either gravitational or associated with a
minimal increase in intravesical pressure.
10.
“stress component” is made with confidence
treatment modalities should be fully discussed
behavioral therapy
timed voiding
fluid management
smoking and caffeine reduction
weight loss
lifestyle modifications.
use of pelvic floor muscle training (PFMT) as first line
therapy
Biofeedback techniques use of vaginal cones
Conservative management
11.
For women who fail or decline
conservative therapy, there are arrays of surgical
options.
12.
Delayed leak
Especially if there is large volume leakage
Difficult to stop
Suggestive of cough-induced detrusor over activity.
Choosing the correct
procedure
13.
Anterior colporrhaphy along with Kelly’s
aplication
38% treatment failure rate
Transabdominal paravaginal repair
20–57% failure rate reported.
Transvaginal needle suspensions like Peyera,
Stamey, Raz, or Gittes procedures, referred to as
needle urethropexy,
higher SUI recurrence (treatment failure) rate
even 1-year follow up
What is currently not preferred ?
15.
Based on route of approach,
the surgical procedures for SUI can be divided into
either abdominal (open/laparoscopic/robotic) or
vaginal.
revolutionary changes in the last decade
new minimally invasive techniques safe and
effective.
Choosing the Correct
Procedure
16.
There are nearly 200 surgical procedures
Designed to restore the bladder neck and urethra to their
anatomically correct positions
The choice of surgical procedure depends on a
number of factors
including the presence of bladder or uterine prolapse,
severity of incontinence,
surgeon’s experience in performing specific types of
surgery.
Choice of Surgery
18.
PROCEDURE
COLPOSUSPENSION
(BURCH ,MMK)
VAGINAL
SUSPENSION
SUBRETHRAL SLING
(TVT,TOT,MINI SLINGS)
GOALS
ELEVATES AND STABILIZE
UTRTHRA BY
SUSPENDING ANTERIOR
VAGINAL WALL TO
ILIOPECTINEAL COOPERS
LIGAMENT
STABILISES URETHRA BY
SUPORTING
PARAURTHRAL TISSUE
AND ANTERIOR VAGINAL
WALL
STABILIZING URETHRA BY
PLACING SUB URETHRAL
SLING ATTACHED TO
RECTUS FASCIA OR PUBIC
BONE
19.
sub-mucosaly
apposition of the urethral wall.
local anesthetia
low associated morbidity
autologous fat
collagen to manufactured polymers (Teflon, Durasphere,
Macroplastique).
Both subjective and objective short-term improvement
Longer term studies are necessary before injection
therapy
Urgency urinary retention, hematuria and particle
migration leading to granuloma
PERI-URETHRAL
BULKING AGENTS
20.
(sometimes called colpo cysto urethropexy)
standard approach.
wide abdominal incision
often performed during abdominal surgeries
such as hysterectomy or hernia operations
along with sacrocolpopexy into the vagina.
Burch Colposuspension
21.
22.
principle of elevating and fixing the bladder neck
and proximal urethra in a retropubic position to
enhance support.
The most widely used technique is the Burch
colposuspension and this procedure has been used
as a gold standard with which to compare newer
surgical treatments for SUI.
RETROPUBIC SUSPENSION
PROCEDURES
24.
The MMK approach requires a wide abdominal
incision.
The surgeon then elevates the urethra and bladder
neck using sutures.
These structures are then secured and anchored to
underneath the pelvic bone.
Marshall-Marchetti-
Krantz (MMK).
25.
long-term performance of this procedure is uncertain.
higher complication rates
longer operating time
less intraoperative blood loss
less postoperative pain
shorter hospital stay
quicker return to normal activities
shorter duration of catheterization
Direct comparison studies of laparoscopic versus open
colposuspension are surprisingly few and far between.
Laparoscopic
colposuspension
26.
“smaller is better” concept
Management an ongoing quest
for perfected treatment options
more efficacious outcomes
minimal patient morbidity
Next needleless, single small vaginal incision technique
could perhaps be the total elimination of any incision at
all
Mini slings
27.
Retropubic MUS more suppression efficiency
Trans obturater approach less suppression
efficiency
Apical prolapse abdominal approach
simultaneous burch colposuspension
Mild urethral sling is choice
28.
High quality trials
Newer outpatient procedures
No abdominal incisions
small incision in the vagina.
two small tacks are placed in the pubic bone.
A sling is inserted into the vagina and is attached to the tack.
The tension-free vaginal tape (TVT) procedure uses a special gauze
tape covered by a polypropylene coating,
which is attached on each side of the urethrawith
stress incontinence cure rates of 84 - 100%.
The benefits of TVT may last for up to 8 years for women with stress
incontinence.
However, women with mixed incontinence (a combination of stress
and urge) may not do as well with the TVT procedure.
first-line surgical
approach SLING
PROCEDURE
29.
minimal possible
inflammation
fibrosis
shrinkage
a non Current absorbable polymer
which mesh to choose
30.
Type 1 monofilament
No sharp leaving fibers or edges
Low elasticity
High dimensional stability
Large pores
Better tissue integration
Prevent bridging
Development of a firm scar plate over the mesh.
39.
A type of retropubic colposuspension in which the
endopelvic fascia next to the bladder neck is attached
to the periosteum of the posterior pubic symphysis,
is also presently not recommended.
MMK has been used as an alternative to Burch’s
colposuspension, but Burch emerges as more
effective (lesser treatment failure rate) and with
lesser morbidity than MMK.
Key points
40.
Women who have symptoms suggestive of SUI and
confirmed by clinical examination require treatment,
and may be offered a trial of conservative therapy
initially.
Women with uncomplicated SUI can be offered
corrective surgery by a vaginal or abdominal route, with
vaginal routeas route of choice except in patients of POP
(apical prolapse) being corrected by abdominal
sacrohysteropexy/sacrocolpopexy.
For most women with uncomplicated SUI who require
and desire surgical treatment, midurethral
transobturator sling remains the procedure of choice, in
the light of currently available evidence.
Key points
41. urinary incontinence and it is a problem, which requires
treatment, and can be treated
Cotton swab test, perineal pad test, urodynamic testing
are not required for diagnosis or management of
uncomplicated SUI.
PVR urine may be measured by a simple office
ultrasound before performing a MUS surgery in women
with SUI.
uncomplicated SUI who require and desire surgical
treatment, midurethral transobturator sling remains the
procedure of choice.
Keypoints
42.
A retropubic approach may have superior efficacy
Higher risk of complications
Single vaginal incision minislings new promising
Presently available evidence favoring minislings
Not conclusive recommendation between minislings
and full-length midurethral tapes.
Minislings have a potential to relieve, groin pain the
only itch full length transobturator tapes
Maiden data suggests using a U-shaped minisling
rather than H-positioned sling.
Key points
43.
Currently, evidence in favor of the use of sub-
urethral tapes especially tension-free vaginal tapes
suggests that a new standard of low morbidity and
high efficacy surgical treatment for SUI has been set.
Key points
44.
Surgical management –Revolutionary
Retropubic MUS –offered distinct advantage
Trans obturator sling – safer means tension free
Mini sling – smaller is better concept
Conclusion