The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

1. STEM CELLS
SEMINAR ON
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INDIAN DENTAL ACADEMY
Leader in continuing Dental
Education

2. CONTENTS
 Introduction
 What is stem cell ?
 Classification
 Embryonic stem cells
 Adult stem cells
 Stem cell marker
 Clinical applications
 Stem cell safety
 Ethical debate
 References
 Conclusion. www.indiandentalacademy.com

3. If whales could fly
INTRODUCTION
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4. Differentiation of
human tissues
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5. What is stem cell ?
A cell that has ability to divide and
differentiate .
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7. CLASSIFICATION
EMBRYONIC
ADULT
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8. TERMINOLOGIES
• Totipotent stem cells - Eg. Fertilised egg
• Pluripotent stem cells - Eg. Embryonic stem cells
• Unipotent stem cells - Eg. Adult stem cells
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9. Human blastocyst
EMBRYONIC STEM CELLS
 Cells that are derived from the undifferentiated inner cell
mass of the blastocyst are called embryonic stem cells.
 Pluripotent www.indiandentalacademy.com

10. Generating
embryonic stem cell
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11. ADULT STEM CELLS
 They are undifferentiated cells found among differentiated
cells of a specific tissue.
 Usually unipotent cell
 Source
Hematopoietic
Stromal
• Bone marrow
• Central nervous system
• Cornea and retina of eye
• Olfactory cells
• Umbilical Cord blood
• Skin
• Adipose tissue
• Gastrointestinal tract
• Liver
• The dental pulp
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12. Hematopoietic and stromal stem cell differentiation
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13. STEM CELL MARKERS
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15. How researches find stem cells ?
 Fluorescence activated cell sorting
 Microscopic image of fluorescent labeled stem cell
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17. Differentiated cells
Undifferentiated stem cells
MICROSCOPIC IMAGE OF FLUORESCENT LABELED
STEM CELLS
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18. STEM CELL APPLICATIONS
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19. Scheme for
transplantation
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20. APPLICATIONS
 Autoimmune diseases
 Diabetes
 Rebuilding the nervous system
 Repair of damaged heart
 Therapeutic gene delivery
 Basic research
 Regenerative dentistry
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21. Rodent model of
myocardial infarction
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22. Heart muscle repair with adult stem cells
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23. REGENERATIVE DENTISTRY
The Times of India, Aug 15th
,2005.
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24. Regenerative dentistry
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25. Regenerative dentistry
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26. Prof.Paul Sharpe
Regenerative dentistry.
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27. STEM CELL SAFETY
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29. STEM CELL DEBATE
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30.  Destruction of blastocyst
 Political
 Use of nonhuman culture media
STEM CELL DEBATE
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32. 1. Dental and skeletal stem cells : Potential cellular
therapeutics for craniofacial regeneration; Journal of
Dental education,2002; Vol. 66 (6): 766-773.
2. Stem cell based tissue engineering of murine teeth; J Dent
Research, 2004; 83(7): 518-522.
3. Mesenchymal stem cells acquire characteristics of cells in
the periodontal ligament in vitro; J Dent Research 2004;
83(1): 27-34.
4. Stem cells in craniofacial and dental tissue engineering;
Orthod Craniofacial Res, 2005; 8: 54-59.
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34. LET’S FREE OUR MIND, THERE
IS LOT’S TO EXPLORE HERE !
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35. Thank
you. .
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