This document discusses approaches for breeding wheat with resistance to rust diseases. It begins by noting the importance of wheat as a food crop and challenges in meeting future demand. Classical breeding approaches are described that involve determining breeding objectives, assessing genetic variation, crossing, evaluation and selection. Molecular approaches for identifying rust resistance genes using markers can detect variations directly and are not influenced by environment. An efficient breeding program requires clear objectives, understanding pathogen variation and available resistance sources to design programs. Selection of parents, hybridization techniques, bulk and pedigree selection methods, and marker assisted selection are described to introgress resistance while maintaining other important traits.