This document discusses spine injuries, including their definition, epidemiology, anatomy, classification, pathophysiology, diagnosis, management, rehabilitation, complications, prevention, and current trends. Spine injuries refer to damage to the bony or ligamentous structures of the spine, which can occur with or without neurological impairment. They are frequently caused by motor vehicle accidents or falls and require early recognition and treatment to achieve good outcomes. Management involves pre-hospital stabilization and transport, hospital evaluation and stabilization, and may include surgical or non-surgical techniques depending on the injury. Rehabilitation aims to prevent complications and promote recovery, while efforts should also focus on prevention to reduce the incidence of these often devastating injuries.
The presentation is for the use of Physiotherapy students. It covers a brief introduction, classification, clinical features and general principles of management.
The presentation is for the use of Physiotherapy students. It covers a brief introduction, classification, clinical features and general principles of management.
Potts spine is the classical destruction of disc space and the adjacent bodies , destruction of other spinal elements,severe progressive kyphosis subsequently
Also know as spinal tuberculosis
Cerebral palsy for MBBS (undergraduate medical teaching)Siddhartha Sinha
This presentation gives an overview regarding Cerebral palsy. Its causes, pathogenesis , classification, clinical and examination findings and an overview of its orthopaedic management. Please feel free to drop in any doubts or queries regarding the presentation.
HOW TO MANAGE PATIENTS WITH VERTIGO?
Andradi S.
Department of Neurology. University of Indonesia, Jakarta
disampaikan dalam Simposium PIT IDI Kota Bogor
Appraoch to patient with polytrauma and Damage control orthopedicsKaushal Kafle
A brief approach to patient with polytrauma, physiological response of body with trauma, the trimodal mortality, golden hour, lethal triad of trauma, two hit hypothesis, inflammatory mediators, prehospital care, primary survey, secondary survey, ABCDE approach, Adjucts are included. Besides thc concept of Damage control orthopedics, trend in fracture management , evolution , principle, indication , surgical stratergies, advantage, limitation, definitive fixation and EAC and ETC are included in breif.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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Guidelines on the use of plaster of paris in fracture management. Quite useful for orthopedic residents, GPs, plaster techs, orthopedic care nurses, rehabilitation physicians, physiotherapists
A summarised guide on these often frequently carried out proceduresv - arthrocentesis & arthrotomy. Quite useful for orthopaedic residents, GPs and med students
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. OUTLINE
• INTRODUCTION
– DEFINITION
– STATEMENT OF IMPORTANCE
– EPIDEMIOLOGY
– RELEVANT ANATOMY: VERTEBRAL COLUMN/SPINAL CORD
• AETIOLOGY
• CLASSIFICATION
• PATHOPHYSIOLOGY
– MECHANISMS OF INJURY
– PRIMARY Vs SECONDARY INJURY
• DIFFERENTIAL DIAGNOSIS
• MANAGEMENT
– PRE-HOSPITAL CARE
– HOSPITAL CARE
• REHABILITATION
• COMPLICATIONS
– EARLY
– LATE
• PREVENTION
• CURRENT TRENDS
• CONCLUSION
3. INTRODUCTION
• Spine injury refers to insult to the spine
resulting in damage to its osseoligamentous
components with or without associated
neurologic impairment
• It is a frequently-occurring event with
propensity for devastating consequences.
Early recognition and treatment are central to
achieving satisfactory outcomes.
8. CLASSIFICATION
• STABLE
– A spine injury in which movement of the affected
part would not result in displacement of
fragments
• UNSTABLE
– A spine injury in which movement of the affected
part would result in significant displacement of
fragments thereby causing or aggravating
neurologic injury
9.
10. PATHOPHYSIOLOGY
• MECHANISMS
• Spine injury
– Traction force
– Direct trauma
– Indirect trauma (commonest) – axial compression, flexion,
flexion-rotation, hyperextension, lateral compression,
distraction
• Cord injury
– Direct trauma
– Compression: displaced bone frags, haematoma
– Disruption of blood supply
11.
12.
13. PATHOPHYSIOLOGY
• Primary injury
– Caused by initial trauma
• Secondary injury
– Caused by body’s response to initial injury (begins
within minutes, may last for weeks to months)
– Body’s response comprised by
– Inflammation – vascular changes, oedema, hypoxia
– Loss of ATP-dependent processes
– Ionic derangements
– Accumulation of neurotransmitters
– Production of molecules (arachidonic acid, free radicals,
endogenous opioids)
18. MANAGEMENT – HOSPITAL CARE
• Multidisciplinary approach
• Spine injury centre care is best
• Resuscitation
• Clinical evaluation – maintain high index of
suspicion
– History: pain in neck or back, neurologic impairment,
bladder/bowel incontinence, hx of high risk injury,
other injuries
– Examination:
• General exam – Conscious/unconscious, restless,
shock, other injuries
19. MANAGEMENT – HOSPITAL CARE
• Spine exam
• Inspect head & face for injury
• Inspect spine for deformity, penetrating injury
• Palpate gently for tenderness, bogginess, gap or step
• Other neurological exam
• Carry out power grading for each limb muscle group
• Test for muscle tone and all DTRs
• Anal wink & bulbocavernosus reflex. DRE is mandatory.
• Test each dermatome for sensation and determine the
levels of the various sensory modalities
• Other systemic examination
28. MANAGEMENT – HOSPITAL CARE
• Definitive
– Operative
• Indications
– Unstable fracture with progressive neurologic deficit
– Unstable injuries with neurologic impairment
– Patient’s choice
– To augment spine stability achieve by non-operative means
– Treatment of complications
• Techniques
– Plates
– Rods & screws
– Wires
– Lag screws
29.
30. MANAGEMENT – HOSPITAL CARE
• Supportive care
– Skin care
– Wash, dry & powder skin
– 2-hrly turning
– No creases or crumbs in sheets
– Bladder and bowel care
– Intermittent, aseptic bladder drainage. Commence bladder
training ASAP
– Bowel training with enemas
– Thromboprophylaxis
– Early physiotherapy
– Drugs
31. REHABILITATION
• This should be commenced as early as possible
• Physiotherapy
• Promotes neural recovery
• Prevents DVT/PE
• Prevents contractures
• Occupational therapy
• Psychotherapy
33. PREVENTION
• Effective & adequate traffic policies (as well as
full enforcement) to reduce RTI
• Creation of new roads, resuscitation of old ones
and establishment of an effective rail system
• Establishment of well-structured, adequately
staffed pre-hospital trauma care teams
• Training and retraining of relevant staff in
management of spine injury with establishment
of purpose-built facilities
• Widespread education of public
36. CONCLUSION
• Spine injuries are a clear and present danger
to our economic stability. Apart from being
quite costly to manage, outcomes are
sometimes discouraging despite best care.
• Efforts geared toward prevention will
certainly reduce the burden of this problem
on society as a whole.