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Chapter 10
Psychotherapeutic medication
Goldberg
What percentage of
people with a
mental illness seek
professional help?
A. 90%
B. 55%
C. 40%
D. 10%
90%
55%
40%
10%
0%
25%
71%
4%
Mental Illness
 The National Alliance
on Mental Illness
defines mental
illnesses as: “medical
conditions that disrupt
a person’s thinking,
feeling, mood, ability
to relate to others and
daily functioning”
Demographics
 10-15% of the general population receive
drugs for emotional problems each year
 43% of people with mental disorders reside
in the US and Europe
 1 in 3 Americans suffer from a mental
disorder
 Antidepressants are the medication most
frequently used by people aged 18–44
Early Treatment of Mental
Disorders
 Before 1950, people
with mental illness
were subjected to
abysmal treatment
 Depression was
treated with
amphetamines; other
types of mental
illnesses were
treated with
sedatives
History
 Electroconvulsive therapy (ECT), first developed in
1938, was used to treat depression and psychosis
 Electrical activity in the brain is temporarily
interrupted and a seizure within the brain is triggered
 Many patients experienced adverse cognitive effects
 Despite concerns, ECT is still a treatment option
Disorders
 Anxiety disorders
 Obsessive-compulsive
disorders
 Mood disorders
 Depression
 Mania/Bipolar
 Psychosis
Diagnosis of Mental Disorders
 DSM-5 criteria
 Clinically significant distress or impairment in social,
academic (occupational) or other important areas of
functioning
 Not attributable to the physiological effects of a
substance or another medical condition
 Dual-diagnosis
 VERY QUICK OVERVIEW – YOU WILL NOT BE ABLE
TO DIAGNOSE ANYONE, EVEN YOURSELF!
It is important to rule out substance use
as a cause of symptoms because
A. Patients could be lying
about their use of
drugs
B. Intoxication can
resemble some
symptoms of mental
disorders
C. A patient can’t be
diagnosed with both
mental illness and
substance abuse
Patientscould
belying
...
Intoxication
can
resem
bl...
A
patientcan’tbe
diag...
0%
8%
92%
How are you keeping up?
A. Great, this makes
sense.
B. Pretty well, but I’m
going to need to
do some reading.
C. Michelle, I’m lost.
Great,thism
akessense.
Pretty
w
ell,butI’m
going...
M
ichelle,I’m
lost.
71%
0%
29%
Disorders with Anxiety
Symptoms
 Anxiety Disorders
 Panic Disorder
 Social Anxiety
 Phobias
 Obsessive
Compulsive Disorder
 Post-traumatic Stress
Disorder
Treatment often
includes
use of sedative-
hypnotic
drugs
Anxiety Videos
 Panic Attack:
http://digital.films.com/PortalViewVideo.a
spx?xtid=6788
 OCD:
http://digital.films.com/PortalViewVideo.a
spx?xtid=41357
Medications for Anxiety
 Long-acting benzodiazepines
Most people have a phobia of
some sort
A. True
B. False
True
False
83%
17%
Repeatedly washing one’s hands is
an example of an obsession.
A. True
B. False
True
False
77%
23%
People with panic
disorder alter their
behavior to avoid
another panic attack
A. True
B. False
True
False
0%
100%
Mood Disorders
 Major Depression
 Manic Episodes
 Bipolar Disorder
Depression
 Depressed mood most of the day, nearly every day
 Diminished interest or pleasure in activities
 Disturbances in appetite
 Disturbances in sleep
 Psychomotor agitation or retardation
 Fatigue/loss of energy
 Feelings of worthlessness/
guilt
 Diminished ability to
concentrate
 Recurrent thoughts of
death
Mood Disorder Videos
 Manic episode:
http://youtu.be/p9hbXPVaOuk
 Depressive episode:
http://digital.films.com/PortalViewVideo.a
spx?xtid=41085#
Before giving antidepressants to
children:
A. The medications were
tested for effectiveness
B. The medications were
tested for safety
C. The medications were
not tested on children
Them
edicationsw
erete...
Them
edicationsw
erete...
Them
edicationsw
ereno...
0%
73%
27%
Medications for Mood Disorders
 Antidepressants
 Monoamine Oxidase Inhibitors
 Tricyclic Antidepressants
 Selective Serotonin Reuptake Inhibitors
 Electroconvulsive therapy (not
medication)
 Mood stabilizers
Video
 Depressive episode:
http://digital.films.com/PortalViewVideo.a
spx?xtid=41085#
 http://www.halfofus.com/video/scott/
Anti-depressant
Medications
 Monoamine oxidase inhibitors (MAOIs)
 Tricyclic antidepressants
 Selective serotonin reuptake inhibitors
(SSRIs)
 Serotonin and norepinephrine reuptake
inhibitors (SNRIs)
 Atypical antidepressants that do not fall
into one of the above categories
SSRIs
 Selective serotonin reuptake
inhibitors (SSRIs)
 Antidepressant medications that increase the
concentration of serotonin in the brain
 Reduce aggressive and violent behavior
 Adverse effects include sexual dysfunction,
increase in weight, and altered sleep patterns
 Not much more effective than placebos
Although antidepressants
are only slightly more
effective than placebos,
most patients feel they help.
A. True
B. False
True
False
0%0%
Manic Episode
 Inflated self-esteem
 Decreased need for sleep
 Talkative
 Flight of ideas
 Distractibility
 Increase in goal-directed activity
 Excessive involvement in risky behavior
Video
 http://youtu.be/p9hbXPVaOuk
A manic episode can resemble:
A. Being drunk
B. Being high on
marijuana
C. Being high on
cocaine
BeingdrunkBeinghigh
on
m
arijuanaBeinghigh
on
cocaine
4%
96%
0%
Medications for Bipolar
Disorder/Manic Episode
 Lithium
 Effective for acute mania and prevents
recurrence
 Maximal benefit is achieved in one to two weeks
 Effective for unipolar depression not responsive
to other antidepressant drugs
 The therapeutic window is small – three to four
times the therapeutic level can cause grave
consequences
 Chlorpromazine
 Fewer toxic side effects
Non-compliance with med
schedules is a problem with lithium
because
A. Patients are
hallucinating
B. Patients like the feeling
of a manic episode
C. It takes several months
for the dose to reach
therapeutic threshold
Patientsarehallucinating
Patientslikethe
feeling..
Ittakesseveralm
onthsf..
0%
15%
85%
Psychosis
 Psychosis
 Severe mental condition marked by loss of contact with
reality
 Organic psychoses
 Have physical causes such as excessive drug use, brain
infections, metabolic or endocrine disorders, brain tumors,
and neurological diseases
 Functional psychoses
 Have no known or apparent cause (e.g. schizophrenia)
Schizophrenia
 Psychosis
• Delusions
• Hallucinations
• Disorganized Speech
• Disorganized Behavior
• Negative Symptoms
The number of children taking
antipsychotic drugs has increased
in the US. In Europe:
A. Rates have slightly
increased as well
B. Rates have remained
the same
C. Rates have decreased
D. Rates have increased
at an alarming rate,
doubling the numbers
Rateshaveslightlyincre...
Rateshaverem
ained
the...
Rateshavedecreased
Rateshaveincreased
ata...
23% 23%
31%
23%
Psychosis is
A. Blunting of
emotional
expression
B. A loss of touch
with reality
C. Always marked by
hallucinations
Bluntingofem
otionalex...
A
lossoftouch
w
ith
reality
Alw
aysm
arked
byhalluc...
0%
15%
85%
Video
 Schizophrenia:
http://digital.films.com/PortalViewVideo.a
spx?xtid=11024#
 Schizophrenia:
http://digital.films.com/PortalViewVideo.a
spx?xtid=42758
 4 patients
https://www.youtube.com/watch?v=bWa
Fqw8XnpA 7:12
Antipsychotic Drugs
 Antipsychotic drugs (neuroleptics) used
particularly for schizophrenia
 Pharmacologically different from other
sedative-hypnotic drugs
 They block dopamine
 Four to six weeks for maximum
effectiveness
Antipsychotic Drugs
 Absorbed erratically
 Sometimes given by injection so the drug
can be released slowly into the
bloodstream
 Build up in fatty areas of brain and lungs,
and cross the placenta to affect the fetus
Antipsychotic Drugs
 Patients almost always show improvement,
but a small percentage gets worse
 Improvement is most rapid during the first
several weeks of treatment
 Although many people taking antipsychotic
drugs relapse, it appears that these drugs
reduce violent behavior
Side Effects
 Parkinsonism
 tremor, slow movement, impaired speech or
muscle stiffness — especially resulting from the
loss of dopamine
 Tardive dyskinesia
 Motor disorders such as involuntary repetitive
facial movements, lip smacking, involuntary
movement of trunk and limbs, and twitching
Which is not true of
antipsychotic drugs?
A. Takes 4-6 weeks for max
effect
B. Side-effects are mild and
easily reversed
C. They are absorbed
unevenly
D. They block dopamine
Takes4-6w
eeksform
ax...
Side-effectsare
m
ild
and...
Theyare
absorbed
unevenly
Theyblockdopam
ine
8%
4%
19%
69%
Dual Diagnosis
• Two or more
co-existing
mental
illnesses
• Common
Example:
• Substance
Use Disorder
& Depression
Increased Medication Use =
Consequences for Society
 Number of hospitalizations decreased
 Lack of outpatient services
 Psychiatrists spend much time
prescribing/managing medications
 Civil Rights issues around hospitalization
 Non-compliance with medication regimen
 Jail
 Homelessness
Psychotherapeutic Drug Abuse
• 7 million Americans
• Unintentional poisoning deaths
increased by 84% (1999-2004)

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Soc 204 goldberg ch 10

  • 2. What percentage of people with a mental illness seek professional help? A. 90% B. 55% C. 40% D. 10% 90% 55% 40% 10% 0% 25% 71% 4%
  • 3. Mental Illness  The National Alliance on Mental Illness defines mental illnesses as: “medical conditions that disrupt a person’s thinking, feeling, mood, ability to relate to others and daily functioning”
  • 4. Demographics  10-15% of the general population receive drugs for emotional problems each year  43% of people with mental disorders reside in the US and Europe  1 in 3 Americans suffer from a mental disorder  Antidepressants are the medication most frequently used by people aged 18–44
  • 5. Early Treatment of Mental Disorders  Before 1950, people with mental illness were subjected to abysmal treatment  Depression was treated with amphetamines; other types of mental illnesses were treated with sedatives
  • 6. History  Electroconvulsive therapy (ECT), first developed in 1938, was used to treat depression and psychosis  Electrical activity in the brain is temporarily interrupted and a seizure within the brain is triggered  Many patients experienced adverse cognitive effects  Despite concerns, ECT is still a treatment option
  • 7. Disorders  Anxiety disorders  Obsessive-compulsive disorders  Mood disorders  Depression  Mania/Bipolar  Psychosis
  • 8. Diagnosis of Mental Disorders  DSM-5 criteria  Clinically significant distress or impairment in social, academic (occupational) or other important areas of functioning  Not attributable to the physiological effects of a substance or another medical condition  Dual-diagnosis  VERY QUICK OVERVIEW – YOU WILL NOT BE ABLE TO DIAGNOSE ANYONE, EVEN YOURSELF!
  • 9. It is important to rule out substance use as a cause of symptoms because A. Patients could be lying about their use of drugs B. Intoxication can resemble some symptoms of mental disorders C. A patient can’t be diagnosed with both mental illness and substance abuse Patientscould belying ... Intoxication can resem bl... A patientcan’tbe diag... 0% 8% 92%
  • 10. How are you keeping up? A. Great, this makes sense. B. Pretty well, but I’m going to need to do some reading. C. Michelle, I’m lost. Great,thism akessense. Pretty w ell,butI’m going... M ichelle,I’m lost. 71% 0% 29%
  • 11. Disorders with Anxiety Symptoms  Anxiety Disorders  Panic Disorder  Social Anxiety  Phobias  Obsessive Compulsive Disorder  Post-traumatic Stress Disorder Treatment often includes use of sedative- hypnotic drugs
  • 12. Anxiety Videos  Panic Attack: http://digital.films.com/PortalViewVideo.a spx?xtid=6788  OCD: http://digital.films.com/PortalViewVideo.a spx?xtid=41357
  • 13. Medications for Anxiety  Long-acting benzodiazepines
  • 14. Most people have a phobia of some sort A. True B. False True False 83% 17%
  • 15. Repeatedly washing one’s hands is an example of an obsession. A. True B. False True False 77% 23%
  • 16. People with panic disorder alter their behavior to avoid another panic attack A. True B. False True False 0% 100%
  • 17. Mood Disorders  Major Depression  Manic Episodes  Bipolar Disorder
  • 18.
  • 19. Depression  Depressed mood most of the day, nearly every day  Diminished interest or pleasure in activities  Disturbances in appetite  Disturbances in sleep  Psychomotor agitation or retardation  Fatigue/loss of energy  Feelings of worthlessness/ guilt  Diminished ability to concentrate  Recurrent thoughts of death
  • 20. Mood Disorder Videos  Manic episode: http://youtu.be/p9hbXPVaOuk  Depressive episode: http://digital.films.com/PortalViewVideo.a spx?xtid=41085#
  • 21. Before giving antidepressants to children: A. The medications were tested for effectiveness B. The medications were tested for safety C. The medications were not tested on children Them edicationsw erete... Them edicationsw erete... Them edicationsw ereno... 0% 73% 27%
  • 22. Medications for Mood Disorders  Antidepressants  Monoamine Oxidase Inhibitors  Tricyclic Antidepressants  Selective Serotonin Reuptake Inhibitors  Electroconvulsive therapy (not medication)  Mood stabilizers
  • 24. Anti-depressant Medications  Monoamine oxidase inhibitors (MAOIs)  Tricyclic antidepressants  Selective serotonin reuptake inhibitors (SSRIs)  Serotonin and norepinephrine reuptake inhibitors (SNRIs)  Atypical antidepressants that do not fall into one of the above categories
  • 25. SSRIs  Selective serotonin reuptake inhibitors (SSRIs)  Antidepressant medications that increase the concentration of serotonin in the brain  Reduce aggressive and violent behavior  Adverse effects include sexual dysfunction, increase in weight, and altered sleep patterns  Not much more effective than placebos
  • 26. Although antidepressants are only slightly more effective than placebos, most patients feel they help. A. True B. False True False 0%0%
  • 27. Manic Episode  Inflated self-esteem  Decreased need for sleep  Talkative  Flight of ideas  Distractibility  Increase in goal-directed activity  Excessive involvement in risky behavior
  • 29. A manic episode can resemble: A. Being drunk B. Being high on marijuana C. Being high on cocaine BeingdrunkBeinghigh on m arijuanaBeinghigh on cocaine 4% 96% 0%
  • 30. Medications for Bipolar Disorder/Manic Episode  Lithium  Effective for acute mania and prevents recurrence  Maximal benefit is achieved in one to two weeks  Effective for unipolar depression not responsive to other antidepressant drugs  The therapeutic window is small – three to four times the therapeutic level can cause grave consequences  Chlorpromazine  Fewer toxic side effects
  • 31. Non-compliance with med schedules is a problem with lithium because A. Patients are hallucinating B. Patients like the feeling of a manic episode C. It takes several months for the dose to reach therapeutic threshold Patientsarehallucinating Patientslikethe feeling.. Ittakesseveralm onthsf.. 0% 15% 85%
  • 32. Psychosis  Psychosis  Severe mental condition marked by loss of contact with reality  Organic psychoses  Have physical causes such as excessive drug use, brain infections, metabolic or endocrine disorders, brain tumors, and neurological diseases  Functional psychoses  Have no known or apparent cause (e.g. schizophrenia)
  • 33. Schizophrenia  Psychosis • Delusions • Hallucinations • Disorganized Speech • Disorganized Behavior • Negative Symptoms
  • 34. The number of children taking antipsychotic drugs has increased in the US. In Europe: A. Rates have slightly increased as well B. Rates have remained the same C. Rates have decreased D. Rates have increased at an alarming rate, doubling the numbers Rateshaveslightlyincre... Rateshaverem ained the... Rateshavedecreased Rateshaveincreased ata... 23% 23% 31% 23%
  • 35. Psychosis is A. Blunting of emotional expression B. A loss of touch with reality C. Always marked by hallucinations Bluntingofem otionalex... A lossoftouch w ith reality Alw aysm arked byhalluc... 0% 15% 85%
  • 37. Antipsychotic Drugs  Antipsychotic drugs (neuroleptics) used particularly for schizophrenia  Pharmacologically different from other sedative-hypnotic drugs  They block dopamine  Four to six weeks for maximum effectiveness
  • 38. Antipsychotic Drugs  Absorbed erratically  Sometimes given by injection so the drug can be released slowly into the bloodstream  Build up in fatty areas of brain and lungs, and cross the placenta to affect the fetus
  • 39. Antipsychotic Drugs  Patients almost always show improvement, but a small percentage gets worse  Improvement is most rapid during the first several weeks of treatment  Although many people taking antipsychotic drugs relapse, it appears that these drugs reduce violent behavior
  • 40. Side Effects  Parkinsonism  tremor, slow movement, impaired speech or muscle stiffness — especially resulting from the loss of dopamine  Tardive dyskinesia  Motor disorders such as involuntary repetitive facial movements, lip smacking, involuntary movement of trunk and limbs, and twitching
  • 41. Which is not true of antipsychotic drugs? A. Takes 4-6 weeks for max effect B. Side-effects are mild and easily reversed C. They are absorbed unevenly D. They block dopamine Takes4-6w eeksform ax... Side-effectsare m ild and... Theyare absorbed unevenly Theyblockdopam ine 8% 4% 19% 69%
  • 42. Dual Diagnosis • Two or more co-existing mental illnesses • Common Example: • Substance Use Disorder & Depression
  • 43. Increased Medication Use = Consequences for Society  Number of hospitalizations decreased  Lack of outpatient services  Psychiatrists spend much time prescribing/managing medications  Civil Rights issues around hospitalization  Non-compliance with medication regimen  Jail  Homelessness
  • 44. Psychotherapeutic Drug Abuse • 7 million Americans • Unintentional poisoning deaths increased by 84% (1999-2004)