This document summarizes information about three viral infections: smallpox, chickenpox, and influenza. It describes the causative agents, symptoms, modes of transmission, diagnosis, treatment and prevention for each. Smallpox was eradicated through a global vaccination campaign. Chickenpox is caused by the varicella zoster virus and presents with a rash. Influenza is an acute respiratory infection caused by influenza viruses and spreads rapidly.
An introduction to Rhabdoviridae.Rabies is a viral disease that causes acute inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. Once symptoms appear, the result is nearly always death. The time period between contracting the disease and the start of symptoms is usually one to three months; however, this time period can vary from less than one week to more than one year. The time is dependent on the distance the virus must travel to reach the central nervous system.
Bunyavirus, any virus belonging to the family Bunyaviridae. Bunyaviridae is a family of arthropod-borne or rodent-borne, spherical, enveloped RNA viruses. Bunyaviruses are responsible for a number of febrile diseases in humans and other vertebrates. They have either a rodent host or an arthropod vector and a vertebrate host.
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s
Polio: flaccid paralysis, major and minor
disease, fecal-oral
Coxsackievirus A: vesicular diseases,
meningitis; coxsackievirus B (body):
pleurodynia, myocarditis
Other echovirus and enteroviruses: like
coxsackievirus
Rhinoviruses: common cold, acid labile, does
not replicate above 33° C
Biology, Virulence, and Disease
• Small size, icosahedral capsid, positive RNA
genome with terminal protein
• Genome is sufficient for infection
• Encodes RNA-dependent RNA polymerase,
replicates in cytoplasm
Enteroviruses
• Capsid virus resistant to inactivation
• Disease due to lytic infection of important
target tissue
• Polio: cytolytic infection of motor neurons of
anterior horn and brainstem, paralysis
• Coxsackievirus A: herpangina, hand-foot-
and-mouth disease, common cold,
meningitis
• Coxsackievirus B: pleurodynia, neonatal
myocarditis, type 1 diabetes
Rhinoviruses
• Acid labile and cannot replicate at body
temperature
• Restricted to upper respiratory tract
• Common cold
Epidemiology
• Enteroviruses transmitted by fecal-oral route
and aerosols
• Rhinoviruses transmitted by aerosols and
contact
Diagnosis
• Immune assays (ELISA) or RT-PCR genome
analysis of blood, CSF, or other relevant
sample
Treatment, Prevention, and Control
• OPV and IPV polio vaccines
P
icornaviridae is one of the largest families of viruses and
includes some of the most important human and animal
viruses (Box 46-1). As the name indicates, these viruses are
small (pico) ribonucleic acid (RNA) viruses that have a
naked capsid structure. The family has more than 230
members divided into nine genera, including Enterovirus,
Rhinovirus, Hepatovirus (hepatitis A virus; discussed in
Chapter 55), Cardiovirus, and Aphthovirus. The enterovi-
ruses are distinguished from the rhinoviruses by the stabil-
ity of the capsid at pH 3, the optimum temperature
for growth, the mode of transmission, and their diseases
CHICKEN POX is an important viral disease which is similar to small pox in its presentation. the characteristic feature of this disease is pleomorphic rash,meaning by all stages of rash are present at one point of time. it can be easily prevented by the use of a vaccine.
INTRODUCTION OF COVID-19, ORIGIN OF COVID-19, STRUCTURE OF COVID-19, CAUSES OF CORON VIRUS, SYMPTOMS OF COVID-19, TYPICAL SYMPTOMS OF COVID-19, MODE OF TRANSMISSION, PEOPLE WHI ARE AT HIGHER RISK, WHY COVID-19 IS SAID T BE AS THE PANDEMIC BY WHO?, PREVENTION, WHAT TO DO, WHAT NOT TO DO, MYTHS AND FACTS OF COVID-19 SPREADING, SOME OTHER CONSEQUENCES OF COVID-19, MOST IMPORTANT POINTS OF COVID-19, COVID-19 VACCINES INTRODUCTION, TYPES OF VACCINES , COVAXIN, COVISHIELD, COVID VACCINE REGISTERATION, WHO CAN REGISTER, WHO SHOULDNT TAKE VACCINE SHOTS, STEP BY STEP GUIDE FOR REGISTERATION, COMPARISON BETWEEN COVAXIN AND COVISHIELD,
An introduction to Rhabdoviridae.Rabies is a viral disease that causes acute inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. Once symptoms appear, the result is nearly always death. The time period between contracting the disease and the start of symptoms is usually one to three months; however, this time period can vary from less than one week to more than one year. The time is dependent on the distance the virus must travel to reach the central nervous system.
Bunyavirus, any virus belonging to the family Bunyaviridae. Bunyaviridae is a family of arthropod-borne or rodent-borne, spherical, enveloped RNA viruses. Bunyaviruses are responsible for a number of febrile diseases in humans and other vertebrates. They have either a rodent host or an arthropod vector and a vertebrate host.
A picornavirus is a virus belonging to the family Picornaviridae, a family of viruses in the order Picornavirales. Vertebrates, including humans, serve as natural hosts. Picornaviruses are nonenveloped viruses that represent a large family of small, cytoplasmic, plus-strand RNA viruses with a 30-nm icosahedral capsid.
A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s
Polio: flaccid paralysis, major and minor
disease, fecal-oral
Coxsackievirus A: vesicular diseases,
meningitis; coxsackievirus B (body):
pleurodynia, myocarditis
Other echovirus and enteroviruses: like
coxsackievirus
Rhinoviruses: common cold, acid labile, does
not replicate above 33° C
Biology, Virulence, and Disease
• Small size, icosahedral capsid, positive RNA
genome with terminal protein
• Genome is sufficient for infection
• Encodes RNA-dependent RNA polymerase,
replicates in cytoplasm
Enteroviruses
• Capsid virus resistant to inactivation
• Disease due to lytic infection of important
target tissue
• Polio: cytolytic infection of motor neurons of
anterior horn and brainstem, paralysis
• Coxsackievirus A: herpangina, hand-foot-
and-mouth disease, common cold,
meningitis
• Coxsackievirus B: pleurodynia, neonatal
myocarditis, type 1 diabetes
Rhinoviruses
• Acid labile and cannot replicate at body
temperature
• Restricted to upper respiratory tract
• Common cold
Epidemiology
• Enteroviruses transmitted by fecal-oral route
and aerosols
• Rhinoviruses transmitted by aerosols and
contact
Diagnosis
• Immune assays (ELISA) or RT-PCR genome
analysis of blood, CSF, or other relevant
sample
Treatment, Prevention, and Control
• OPV and IPV polio vaccines
P
icornaviridae is one of the largest families of viruses and
includes some of the most important human and animal
viruses (Box 46-1). As the name indicates, these viruses are
small (pico) ribonucleic acid (RNA) viruses that have a
naked capsid structure. The family has more than 230
members divided into nine genera, including Enterovirus,
Rhinovirus, Hepatovirus (hepatitis A virus; discussed in
Chapter 55), Cardiovirus, and Aphthovirus. The enterovi-
ruses are distinguished from the rhinoviruses by the stabil-
ity of the capsid at pH 3, the optimum temperature
for growth, the mode of transmission, and their diseases
CHICKEN POX is an important viral disease which is similar to small pox in its presentation. the characteristic feature of this disease is pleomorphic rash,meaning by all stages of rash are present at one point of time. it can be easily prevented by the use of a vaccine.
INTRODUCTION OF COVID-19, ORIGIN OF COVID-19, STRUCTURE OF COVID-19, CAUSES OF CORON VIRUS, SYMPTOMS OF COVID-19, TYPICAL SYMPTOMS OF COVID-19, MODE OF TRANSMISSION, PEOPLE WHI ARE AT HIGHER RISK, WHY COVID-19 IS SAID T BE AS THE PANDEMIC BY WHO?, PREVENTION, WHAT TO DO, WHAT NOT TO DO, MYTHS AND FACTS OF COVID-19 SPREADING, SOME OTHER CONSEQUENCES OF COVID-19, MOST IMPORTANT POINTS OF COVID-19, COVID-19 VACCINES INTRODUCTION, TYPES OF VACCINES , COVAXIN, COVISHIELD, COVID VACCINE REGISTERATION, WHO CAN REGISTER, WHO SHOULDNT TAKE VACCINE SHOTS, STEP BY STEP GUIDE FOR REGISTERATION, COMPARISON BETWEEN COVAXIN AND COVISHIELD,
Poxviruses are brick or oval-shaped viruses with large double-stranded DNA genomes. Poxviruses exist throughout the world and cause disease in humans and many other types of animals. Poxvirus infections typically result in the formation of lesions, skin nodules, or disseminated rash.
Epidemiology and control measures for CHICKENPOX {Varicella} AB Rajar
It is an acute, highly infectious disease caused by varicella-zoster(v-z) virus.
It is worldwide in distribution and occurs in both epidemic and endemic forms.
Measles is a highly contagious viral infection.
It is exanthematous disease with fewer, cough, coryza (rhinitis) and conjunctivitis.
Before the widespread use of measles vaccines, it was estimated that measles caused between 5 million and 8 million deaths worldwide each year.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
2. SMALLPOX
• Smallpox is an acute, highly infectious disease, caused
by Variola virus. Previously, it was one of the greatest
killer disease in India.
• In 1967,WHO began an intensified world wide
campaign to eradicate smallpox, based on the
technique of surveillance and containment.
• The last known case of smallpox in India occurred
on 24th May 1975 and India was declared smallpox
free on 5th July 1975.
3. Causative agent: Variola virus
variola virus, a member of the orthopoxvirus family
The variola virus is a large, brick-shaped, double-
stranded DNA virus.
4. Symptoms
• Fever
• Muscle aches
• Headache
• Severe fatigue
• Severe back pain
• Vomiting
A few days later, flat, red spots appear on the
body. They may start in the mouth and on the
tongue and then spread to the skin. The face,
arms and legs are often affected first, followed
by the torso, hands and feet.
Incubation period:11 to 14 days
5. Within a day or two, many of the spots turn into
small blisters filled with clear fluid. Later, the
blisters fill with pus. These sores are called
pustules. Scabs form 8 to 9 days later and
eventually fall off, leaving deep, pitted scars.
Mode of transmission
Directly from person to person
Indirectly from an infected person
Through contaminated items
Diagnosis
The disease can be definitively diagnosed by
isolation of the virus from the blood or lesions, or
by identification of antibodies in the blood made in
response to the virus.
6. There is no cure for smallpox, but vaccination can
be used very effectively to prevent infection from
developing if given during a period of up to four
days after a person has been exposed to the virus.
This is the strategy that was used to eradicate the
disease during the 20th century.
Vaccination with replication-competent smallpox
vaccines (i.e., ACAM2000 and APSV) can prevent or
lessen the severity of disease if given within 2 to 3
days of the initial exposure
Treatment of smallpox patients generally involves
supportive care and antiviral drugs.
Treatment and prevention
7.
8. CHICKENPOX
• Chickenpox is an acute Infectious disease.
• It is caused by Varicella zoster virus.
• Chickenpox is quite a common disease in
India.
• It occurs in both epidemic and endemic
forms.
Varicella zoster virus, also known as human herpesvirus
3 or Human alphaherpesvirus 3, that can infect
humans. VZV has a linear, double-stranded DNA
genome
9. Source of infection:The virus is present in the
nose and throat secretion and lesions of the
skin, mucous membranes and blood.
Incubation period:14 to 16 days
Mode of transmission
• Droplet infection
• Droplet nuclei
• Face to face contact
• Contaminated articles
10.
11. Symptoms
• Pre-eruptive stage : Onset is sudden with mild
or moderate fever, pain in the back, shivering
and malaise. This stage is very brief, lasting
about 24 hours.
• Eruptive stage:In children the rash is often the
first sign. It comes on the day the fever starts.
Most often, health care providers find out you have
chickenpox based on the rash.
Chickenpox also can be confirmed with lab tests,
including blood tests or a tissue study of samples of
affected skin.
Diagnosis
12. Prevention
1.Varicella zoster immunoglobulin (VZIG)
VZIG given within 72 hours of exposure has
been recommend for prevention of chickenpox.
2. A live attenuated varicella virus vaccine is safe
and currently recommended for children between
12 to 18 months of age who have not had
chickenpox.
Control measures
Isolation of cases for about 6 days after onset of
rash and disinfection of articles soiled by nose
and throat discharge.
Several antiviral compounds provide effective
therapy for varicella including acyclovir,
valaciclover, famiciclover and foscarnet.
13.
14. INFLUENZA
• Influenza commonly known as Flu is an acute
infection of the respiratory tract.
• It is caused by the influenza viruses.
• Influenza tends to spread very rapidly.
• Pandemics of influenza occurred in 1957and 1968 .
Three immunological types of influenza viruses are
known, namely Type A, B and C. Type A causes the most
severe type of infection.
Influenza A virus is an enveloped virus with a
segmented, single-strand, negative-sense RNA genome.
15.
16. Incubation period:18 to 72 hours
Mode of transmission
Direct contact
Droplet infection
Handling or using articles recently
contaminated
Symptoms
Fever
Headache
Shivering
Sore throat with sneezing and nasal block
Cough
Pains all over the body
Weakness
17. Diagnosis
Diagnostic tests available for influenza include viral
culture, serology, rapid antigen testing, reverse
transcription polymerase chain reaction (RT-PCR),
immunofluorescence assays, and rapid molecular
assays.
18. Prevention
1.Killed vaccine:Killed vaccines are widely used for
protection against influenza but they are not completely
protective. The vaccine is administered by subcutaneous
or intramuscular route.
2.Live -attenuated vaccines:A trivalent, live-attenuated
influenza vaccine administered as a single dose
3.Intranasal spray is as effective as inactivated vaccine in
preventing the disease.
