1. In 1977, Whitfield Diffie and Martin Hellman proposed the idea of public-key cryptography, where one key is used for encryption and another for decryption.
2. In 1978, Ronald Rivest, Adi Shamir and Leonard Adelman published the RSA algorithm, which became the de facto standard for public-key cryptography for 30 years. It uses a "trap-door" based on the difficulty of factoring large numbers.
3. The RSA algorithm works by using two large prime numbers to generate a public key for encryption and a private key for decryption. Encryption and decryption are done by exponentiation and taking the remainder modulo the product of the prime numbers.
[Question Paper] Fundamentals of Digital Computing (Revised Course) [April / ...Mumbai B.Sc.IT Study
This is a Question Papers of Mumbai University for B.Sc.IT Student of Semester - I [Fundamentals of Digital Computing] (Revised Course). [Year - April / 2014] . . .Solution Set of this Paper is Coming soon..
Evaluation of integrals of the given functions along the unit circle on the complex plane. Application of the parametrization method. Evaluation of the integral of an odd function.
Possible applications of low-rank tensors in statistics and UQ (my talk in Bo...Alexander Litvinenko
Just some ideas how low-rank matrices/tensors can be useful in spatial and environmental statistics, where one usually has to deal with very large data
[Question Paper] Fundamentals of Digital Computing (Revised Course) [April / ...Mumbai B.Sc.IT Study
This is a Question Papers of Mumbai University for B.Sc.IT Student of Semester - I [Fundamentals of Digital Computing] (Revised Course). [Year - April / 2014] . . .Solution Set of this Paper is Coming soon..
Evaluation of integrals of the given functions along the unit circle on the complex plane. Application of the parametrization method. Evaluation of the integral of an odd function.
Possible applications of low-rank tensors in statistics and UQ (my talk in Bo...Alexander Litvinenko
Just some ideas how low-rank matrices/tensors can be useful in spatial and environmental statistics, where one usually has to deal with very large data
Understanding the Magic: Teaching Cryptography with Just the Right Amount of ...Joshua Holden
Cryptography is a field which has recently attracted a great deal of attention from both students and teachers of mathematics and of computer science. Students of computer science see cryptography as something which is not only "cool" but may be necessary for them to know in their future careers. Many of them do not realize, however, just how much mathematics they need to know in order to understand the algorithms which lie at the heart of modern cryptography.
For a college course -- CNIT 140: "Cryptography for Computer Networks" at City College San Francisco
Instructor: Sam Bowne
More info: https://samsclass.info/141/141_F17.shtml
Based on "Understanding Cryptography: A Textbook for Students and Practitioners" by Christof Paar, Jan Pelzl, and Bart Preneel, ISBN: 3642041000
An RSA private key is made of a few private variables. We analyze how these private variables are chained together. Further, we study if one of the private variables is leaked, can we derive the other private variables? Demos of the algorithms are also provided.
Information and network security 33 rsa algorithmVaibhav Khanna
RSA algorithm is asymmetric cryptography algorithm. Asymmetric actually means that it works on two different keys i.e. Public Key and Private Key. As the name describes that the Public Key is given to everyone and Private key is kept private
Discrete Logarithmic Problem- Basis of Elliptic Curve CryptosystemsNIT Sikkim
ECC was developed in 1985 independently by Neal Koblitz and Victor Miller. Both men saw the application of the elliptic curve discrete log problem (ECDLP) as a replacement for the conventional discrete log problem (DLP) which is used in DSA, and the integer factorization problem found in RSA. For both problems, sub-exponential solutions have been generated; the
same which cannot be said for ECDLP . In addition to offering increased security for a smaller key size, operations of adding and doubling can be optimized successfully on a mobile
platform . ECC offers a viable replacement to the most common public-key cryptography algorithms on mobile devices.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Comparative structure of adrenal gland in vertebrates
Slides to RSA Presentation
1. left footer right footer – 1 / 19
An Introduction to RSA
David Boyhan
August 5, 2008
2. For 2000 Years ...
left footer right footer – 2 / 19
• Encryption was symmetric:
◦ E(M, k) → C
◦ D(C, k) → M
• The same key k is used for both steps
• Example: Caeser’s Shift Cipher, with k = 3
◦ DM HURTS MY BRAIN ⇒ GP KXUWV OB EUDLQ
• Symmetric Ciphers:
◦ Are subject to interception
◦ Require expensive key distribution
• The same issue exists for steganography and one-time pads.
3. Diffie & Hellman Invent PKC
left footer right footer – 3 / 19
• In 1977, Whitfield Diffie and Martin Hellman published New Directions in
Cryptography proposing a public-key cryptography scheme.
• They propose:
◦ E(M, e) → C
◦ D(C, d) → M
◦ D(C, e) → M
• One key e locks
• One key d unlocks
• e is the public key. d is the private key
• They keys are linked, but d cannot be derived from e.
4. Trap Door Problems
left footer right footer – 4 / 19
Diffie & Hellman suggest use of trap door or one-way problems.
Example:
1. Multiply 13,719 by 23,546 to get 323,041,293
2. Now, factor 323,041,292 into it’s prime factors of 32
∗ 17 ∗ 47 ∗ 167 ∗ 269
Diffie & Merkle attempt use of knapsack problems for the trap door. This is proven to
be cryptographically insecure.
5. Enter RSA
left footer right footer – 5 / 19
• In 1978, Ronald Rivest, Adi Shamir and Leonard Adelman (RSA) publish A
Method for Obtaining Digital Signatures and Public-Key Cryptosystems. This
becomes the de facto standardforstandard for public-key cryptography for 30
years.
• The trap-door is based on factoring of large numbers and modular mathematical
inverse.
• The basic algorithm requires creation/selection of 5 integers:
◦ p and q are large prime numbers
◦ n which is generated by p · q
◦ d which is relatively prime to (p − 1) · (q − 1)
◦ e which is generated by d and n
• M is the original message. C is the cipher-text
6. The RSA Algorithm
left footer right footer – 6 / 19
The algorithm is amazingly simple:
“. . ., the result (the ciphertext C) is the remainder when Me
is divided by
n. To decrypt the ciphertext, raise it to another power d again modulo n .”
E(M) = Me
(mod n) = C
D(C) = Cd
(mod n) = M
7. The Hard Parts ...
left footer right footer – 7 / 19
• Selecting p and q requires rapid testing for primality. This is not too hard.
• Selecting d as gcd(d, ((p − 1) · (q − 1)) = 1 requires basic algorithm (min is
fine, Euclid’s Algorithm is also used)
• Creating e is the complex part (at least for me), because:
e is the multiplicative inverse of d mod ((p − 1) · (q − 1)
• To find modular multiplicative inverse, we need to fine e such that
d · e = 1 mod ((p − 1) · (q − 1))
• To do that, we need Euler’s Totient and Euler’s Generalization of Fermat’s Little
Theorem
8. Euler’s Totient
left footer right footer – 8 / 19
• Euler’s Totient of n, φ(n), is defined as the number of positive integers less than
n that are relatively prime to n.
• if n is prime then φ(n) is simply (n − 1). If both p and q and prime, then it’s
easy to see that φ(p · q) will be ((p − 1) · (q − 1)).
• Example if n is not prime - there are 4 numbers that are relatively prime to 12,
being (1, 5, 7, 11). Therefore φ(12) is 4.
• Calculating Euler’s Totient φ(n) can be done through the prime factorization of
nsuch that n = pk1
1 · · · pkr
r
9. Euler’s Totient (continued)
left footer right footer – 9 / 19
• We then identify the distinct primes and compute φ(n) using the following
formula:
n
p|n
1 −
1
p
• Therefore, for example, 12 = 22
31
so the Totient would be
12 · (1 −
1
2
) · (1 −
1
3
) = 12 ∗
1
2
∗
2
3
= 4.
• Similarly, because the prime factorization of 54 = 21
33
then φ(54) would also
be 54 ∗
1
2
∗
2
3
= 18.
10. Euler’s Generalization of Fermat’s Little Theorem
left footer right footer – 10 / 19
• Euler’s Generalization of Fermat’s Little Theorem states that: if gcd(d, z) = 1
then dφ(z)
mod z = 1. This is a condition we have already satisfied with dand
((p − 1) · (q − 1).
• Substituting ((p − 1) · (q − 1))for z we can see, using Fermat’s Little Theorem
that:
1 = dφ((p−1)·(q−1))
mod ((q − 1) · (p − 1))
11. Euler’s Generalization (continued)
left footer right footer – 16 / 19
• We also know that based on the definition of multiplicative modular inverse that:
e · d = 1(mod(p − 1) · (q − 1))
e · d · d−1
= d−1
· 1(mod(p − 1) · (q − 1))
Substituting in dφ((p−1)·(q−1))
mod ((q − 1) · (p − 1))for 1(mod(p − 1) · (q − 1)),
we get:
e · 1 = dφ((p−1)·(q−1))−1
mod (p − 1) · (q − 1)
12. Example
left footer right footer – 17 / 19
• To create n we’ll use: p = 5, q = 11. n = p · q = 5 · 11 = 55.
• Pick random number that is relatively prime to ((p − 1) · (q − 1)) = d = 7.
• We calculate e using d and Euler’s Generalization of Fermat’s Little Theorem.
Accordingly:
e = dφ((p−1)·(q−1))−1
mod ((p − 1) · (q − 1)) = 7φ(4∗10)−1
mod 4 ∗ 10
• 40 = 23
∗ 51
, therefore, φ(40) = 40 ∗ (1 −
1
2
) ∗ (1 −
1
5
) = 40 ∗
1
2
∗
4
5
= 16
• Therefore, e = 715
mod 40 and e = 23
13. Example - Continued
left footer right footer – 18 / 19
• Finally we’ll start with plain-text message M:DM HURTS MY BRAIN
• For the purposes of this example, we’ll use the integers 1-26 to represent the
alphabet and remove all spaces. However, under normal circumstances, ASCII
would be used instead. Therefore, M becomes: D M H U R T S M Y B R A I N
⇒04 13 08 21 18 20 19 13 25 02 18 01 09 14
• First encrypted block C1 = 0423
(mod 5)5 = 09
• The entire message is encrypted as:09 52 17 21 02 25 39 52 05 08 02 01 14 49
• To decrypt, reverse the process with D(C) = Cd
(mod n) = M
14. The Consequences of RSA
left footer right footer – 19 / 19
• $33 billion in e-commerce transactions for 1st quarter 2008
• In 1991 PGP makes strong cryptography available to everyone
• Philip Zimmermann gets sued and investigated by the FBI
• The US Government proposes the Clipper Chip
• Philip Zimmermann gets an RSA license and the FBI drops the case
• The US Government drops Clipper Chip
• PGP and GNU Privacy Guard are world-wide
• The 2008 Summer Olympics remain ...