This paper summarizes schizophrenia, including common symptoms like delusions, hallucinations, and disorganized thinking. It discusses the social implications such as high costs and increased rates of incarceration rather than treatment. A history of treatments is provided, from exorcisms to lobotomies to modern medications and therapies. The conclusion calls for more facilities to help patients recover and return to productivity.
Parkinson’s: What Do We Know About the Disease and What Can Be Done About It?asclepiuspdfs
ABSTRACT
In this article, I aim to answer important questions regarding Parkinson’s disease and the associated dementia. While the
disease was identified and described over a century ago, we still have not as yet been able to ferret out its root cause,
notwithstanding the tremendous progress made in recent years. Like for many other diseases, it is believed to involve three
main causal components (inherited genetics, environmental influences, and, to a much lesser extent, lifestyle choices),
which collectively determine if someone will develop the disease. I will survey its signs, symptoms (motor and non-motor),
risks, and stages, distinguishing between the disease’s early- and late-onset. While discriminating between the disease and
its associated dementia, I will localize the latter within the broad spectrum of dementias. I will also describe what happens
to the brain as the disease takes hold and evolves. A number of medical conditions called Parkinsonisms may have one or
more of their signs and symptoms mimicking Parkinson’s. I will discuss them in some detail, including their five proposed
mechanisms (protein aggregation in Lewy bodies, disruption of autophagy, mitophagy, neuroinflammation, and breakdown
of the blood–brain barrier). I will further describe the approach to diagnosis, prediction, prevention, and prognosis. While
there is no cure and treatment for each affected person, motor symptoms are managed with several medications (Levodopa
always combined with a dopa decarboxylase inhibitor and sometimes also with a catechol-O-methyltransferase [COMT]
inhibitor, dopamine agonists, and monoamine oxidase-B [MAOB]-inhibitors) and eventually surgical therapy. Numerous
pharmaceutical agents are also available for individual non-motor symptoms (L-Dopa emulsions, non-ergot dopamine
agonists, cholinesterase inhibitors for dementia, modafinil for daytime sleepiness, and quetiapine for psychosis). Fortunately,
we can track the drug effectiveness with exosomes. Keeping in mind patients and their caregivers/partners, I will outline
available complementary therapies, palliative care, and rehabilitation, measures they can take beyond seeking standard
treatments, and supporting and advocating organizations at their disposal. Finally, I will survey promising new research
vistas in the field.
Schizophrenia is a group of severe brain disorders in which people interpret reality abnormally. Schizophrenia may result in some combination of hallucinations, delusions, and disordered thinking and behaviour.
Contrary to some popular belief, schizophrenia is not split personality or multiple personality. The word “schizophrenia” does mean “split mind,” but it refers to a disruption of the usual balance of emotions and thinking (Mayo, 2013).
Schizophrenia is a chronic condition, requiring lifelong treatment.
Parkinson’s: What Do We Know About the Disease and What Can Be Done About It?asclepiuspdfs
ABSTRACT
In this article, I aim to answer important questions regarding Parkinson’s disease and the associated dementia. While the
disease was identified and described over a century ago, we still have not as yet been able to ferret out its root cause,
notwithstanding the tremendous progress made in recent years. Like for many other diseases, it is believed to involve three
main causal components (inherited genetics, environmental influences, and, to a much lesser extent, lifestyle choices),
which collectively determine if someone will develop the disease. I will survey its signs, symptoms (motor and non-motor),
risks, and stages, distinguishing between the disease’s early- and late-onset. While discriminating between the disease and
its associated dementia, I will localize the latter within the broad spectrum of dementias. I will also describe what happens
to the brain as the disease takes hold and evolves. A number of medical conditions called Parkinsonisms may have one or
more of their signs and symptoms mimicking Parkinson’s. I will discuss them in some detail, including their five proposed
mechanisms (protein aggregation in Lewy bodies, disruption of autophagy, mitophagy, neuroinflammation, and breakdown
of the blood–brain barrier). I will further describe the approach to diagnosis, prediction, prevention, and prognosis. While
there is no cure and treatment for each affected person, motor symptoms are managed with several medications (Levodopa
always combined with a dopa decarboxylase inhibitor and sometimes also with a catechol-O-methyltransferase [COMT]
inhibitor, dopamine agonists, and monoamine oxidase-B [MAOB]-inhibitors) and eventually surgical therapy. Numerous
pharmaceutical agents are also available for individual non-motor symptoms (L-Dopa emulsions, non-ergot dopamine
agonists, cholinesterase inhibitors for dementia, modafinil for daytime sleepiness, and quetiapine for psychosis). Fortunately,
we can track the drug effectiveness with exosomes. Keeping in mind patients and their caregivers/partners, I will outline
available complementary therapies, palliative care, and rehabilitation, measures they can take beyond seeking standard
treatments, and supporting and advocating organizations at their disposal. Finally, I will survey promising new research
vistas in the field.
Schizophrenia is a group of severe brain disorders in which people interpret reality abnormally. Schizophrenia may result in some combination of hallucinations, delusions, and disordered thinking and behaviour.
Contrary to some popular belief, schizophrenia is not split personality or multiple personality. The word “schizophrenia” does mean “split mind,” but it refers to a disruption of the usual balance of emotions and thinking (Mayo, 2013).
Schizophrenia is a chronic condition, requiring lifelong treatment.
Schizophrenia is a severe, chronic and disabling mental disorder with a varying course. It is characterised by a breakdown of thought processes and by a deficit of typical emotional responses. It is a clinical syndrome
Schizophrenia is he severe psychotic disorder that affects thinking, emotions, cognition and behavior of an individual. It is majorly known as the perceptual disorder and recognized majorly due to most common illness which is diagnosed dual diagnosis. Psychotherapies, change in lifestyle and the pharmacological management is essentially followed up throughout the course of illness to reduce the symptoms and revert client back to normal. Schizophrenia is an broad spectrum having branched classification under the hood with various symptoms which are too narrowed for acute diagnosis and management.
HIV-AIDS has broader range of course of illness. It is essential for the healthcare workers, specially for psychiatric nurses to know the importance of Counseling as therapeutic modality for clients with HIV-AIDS, as later stages are also attached with psychosis and illnesses like HIV-AIDS are stigmatized in society which also contributes for patient to develop mental health problems. Nurse has roles of advocacy, observant, therapists and comprehensive care giver.
Illness does not ask, it demands. Younger population perceives the un-earning family members as burden on their shoulders with more responsibility, which is taken as an economic loss, even if they are their parents. Anxiety is a broad aspect, which should not be termed as illness- as it is common emotion to experience in every individual’s life. But in 21st century due to defective coping mechanism, poor socialization, sedentary lifestyle- anxiety has become the slow poison to majority of the population, globally. Especially to the elder age group, which highlights the need of quick concern to look after it genuinely. Anxiety is an broad spectrum of disorder, constituting many of the forms which ae common for the human behavior to perform in the society. Management plays the essential role in conflicting the anxiety. Problem solving skills, coping mechanism and self esteem are the basics to tackle the anxiety as a whole.
Schizophrenia is a mental disorder that usually appears in late adolescence or early adulthood. Characterized by delusions, hallucinations, and other cognitive difficulties, schizophrenia can often be a lifelong struggle. In this article, we will cover the causes, symptoms, and treatment of schizophrenia
This is a very basic presentation for anyone who would like to have more information about schizophrenia. This was intended for the third year medical students. The criteria described are based on fourth edition of the DSM ( DSMIV). All these demarcations (types of) schizophrenia will be scrapped by the DSM V (this is the proposal as of now). But this could serve a historical puspose if seen after 2013.
Running head SCHIZOPHRENIA MENTAL DISORDER .docxtoltonkendal
Running head: SCHIZOPHRENIA MENTAL DISORDER 1
SCHIZOPHRENIA MENTAL DISORDER 2
Schizophrenia Mental Disorder
Student’s Name
Course Name
Instructor’s Name
University Affiliation
Schizophrenia Mental Disorder
Introduction
Schizophrenia is a type of psychological illness. It is a chronic and unembellished mental disorder that mainly distresses an individual’s thinking, norms as well as to their extent of sensation. According to modern day research, reports indicates that persons who have schizophrenia might appear as if they have misplaced touch with realism. However, much it is not collective as in comparison with the other mental disorders, its symptoms seem to be much disabling in nature (Miller, 2012). An example is a reduction of a person’s pleasure in their daily undertakings. It raises the question; what can a man do in the absence of desire and affection in all their doings? From the information as already mentioned above, this paper takes turn providing an enhanced analysis of the mental disorder disease – Schizophrenia.
Signs and Symptoms
In close to all the reported cases, signs and symptoms of schizophrenia often start from ages ranging between 16 and 30. There are however fewer cases that the disease has identification among the children. In this paper, it classifies the symptoms and signs into three categories. They include the positive, negative, as well as to the cognitive symptoms as illustrated below.
Positive signs:
In this category, they have a regard for psychotic norms. It means that it is hard to depict the signs commonly in people who are living a healthy lifestyle. However, the given individuals might tend to part ways with their connectivity with different components of reality. The symptoms might include: -
· Delusions
· Agitated movements of the body in a disorderly manner
· Hallucinations
· Unfamiliar perspective of thinking entailing disorderly thoughts and imaginations
Negative symptoms:
In this set, symptoms have a closer affiliation with disturbances to both the common behaviors as well as to particular emotions (Mueser, 2011). The symptoms comprise of: -
· Condensed level of speaking
· Reduction in the extent of both pleasure and feelings in a person’s everyday life undertakings
· Decline on the voice tone as well as the ordinary portrayal of emotions
· Hardships in commencing and sustaining of various activities
Cognitive symptoms:
In this set of symptoms, it varies from one given an individual to the other. To certain people, the symptoms are observable as being delicate in nature. On the other hand, the symptoms prove to be extra severe (Weiberger et al., 2011). In such situations, the affected persons are capable of recognizing alterations in either the facets of thinking and imagination, as well as to variations in their memory. Examples of symptoms ...
Schizophrenia is a severe, chronic and disabling mental disorder with a varying course. It is characterised by a breakdown of thought processes and by a deficit of typical emotional responses. It is a clinical syndrome
Schizophrenia is he severe psychotic disorder that affects thinking, emotions, cognition and behavior of an individual. It is majorly known as the perceptual disorder and recognized majorly due to most common illness which is diagnosed dual diagnosis. Psychotherapies, change in lifestyle and the pharmacological management is essentially followed up throughout the course of illness to reduce the symptoms and revert client back to normal. Schizophrenia is an broad spectrum having branched classification under the hood with various symptoms which are too narrowed for acute diagnosis and management.
HIV-AIDS has broader range of course of illness. It is essential for the healthcare workers, specially for psychiatric nurses to know the importance of Counseling as therapeutic modality for clients with HIV-AIDS, as later stages are also attached with psychosis and illnesses like HIV-AIDS are stigmatized in society which also contributes for patient to develop mental health problems. Nurse has roles of advocacy, observant, therapists and comprehensive care giver.
Illness does not ask, it demands. Younger population perceives the un-earning family members as burden on their shoulders with more responsibility, which is taken as an economic loss, even if they are their parents. Anxiety is a broad aspect, which should not be termed as illness- as it is common emotion to experience in every individual’s life. But in 21st century due to defective coping mechanism, poor socialization, sedentary lifestyle- anxiety has become the slow poison to majority of the population, globally. Especially to the elder age group, which highlights the need of quick concern to look after it genuinely. Anxiety is an broad spectrum of disorder, constituting many of the forms which ae common for the human behavior to perform in the society. Management plays the essential role in conflicting the anxiety. Problem solving skills, coping mechanism and self esteem are the basics to tackle the anxiety as a whole.
Schizophrenia is a mental disorder that usually appears in late adolescence or early adulthood. Characterized by delusions, hallucinations, and other cognitive difficulties, schizophrenia can often be a lifelong struggle. In this article, we will cover the causes, symptoms, and treatment of schizophrenia
This is a very basic presentation for anyone who would like to have more information about schizophrenia. This was intended for the third year medical students. The criteria described are based on fourth edition of the DSM ( DSMIV). All these demarcations (types of) schizophrenia will be scrapped by the DSM V (this is the proposal as of now). But this could serve a historical puspose if seen after 2013.
Running head SCHIZOPHRENIA MENTAL DISORDER .docxtoltonkendal
Running head: SCHIZOPHRENIA MENTAL DISORDER 1
SCHIZOPHRENIA MENTAL DISORDER 2
Schizophrenia Mental Disorder
Student’s Name
Course Name
Instructor’s Name
University Affiliation
Schizophrenia Mental Disorder
Introduction
Schizophrenia is a type of psychological illness. It is a chronic and unembellished mental disorder that mainly distresses an individual’s thinking, norms as well as to their extent of sensation. According to modern day research, reports indicates that persons who have schizophrenia might appear as if they have misplaced touch with realism. However, much it is not collective as in comparison with the other mental disorders, its symptoms seem to be much disabling in nature (Miller, 2012). An example is a reduction of a person’s pleasure in their daily undertakings. It raises the question; what can a man do in the absence of desire and affection in all their doings? From the information as already mentioned above, this paper takes turn providing an enhanced analysis of the mental disorder disease – Schizophrenia.
Signs and Symptoms
In close to all the reported cases, signs and symptoms of schizophrenia often start from ages ranging between 16 and 30. There are however fewer cases that the disease has identification among the children. In this paper, it classifies the symptoms and signs into three categories. They include the positive, negative, as well as to the cognitive symptoms as illustrated below.
Positive signs:
In this category, they have a regard for psychotic norms. It means that it is hard to depict the signs commonly in people who are living a healthy lifestyle. However, the given individuals might tend to part ways with their connectivity with different components of reality. The symptoms might include: -
· Delusions
· Agitated movements of the body in a disorderly manner
· Hallucinations
· Unfamiliar perspective of thinking entailing disorderly thoughts and imaginations
Negative symptoms:
In this set, symptoms have a closer affiliation with disturbances to both the common behaviors as well as to particular emotions (Mueser, 2011). The symptoms comprise of: -
· Condensed level of speaking
· Reduction in the extent of both pleasure and feelings in a person’s everyday life undertakings
· Decline on the voice tone as well as the ordinary portrayal of emotions
· Hardships in commencing and sustaining of various activities
Cognitive symptoms:
In this set of symptoms, it varies from one given an individual to the other. To certain people, the symptoms are observable as being delicate in nature. On the other hand, the symptoms prove to be extra severe (Weiberger et al., 2011). In such situations, the affected persons are capable of recognizing alterations in either the facets of thinking and imagination, as well as to variations in their memory. Examples of symptoms ...
Folks with schizophrenia may hear voices that are not there. Some may be convinced that other folks are reading their thoughts, controlling how they think, or plotting against them. This can distress patients severely and persistently, making them withdrawn and frantic.
CHAPTER SEVENAntipsychotic MedicationsThe Evolution of Treatme.docxtiffanyd4
CHAPTER SEVEN
Antipsychotic Medications
The Evolution of Treatment
Many readers may begin this chapter with some familiarity with antipsychotic medications. Others may think antipsychotic medications or the research related to them has not affected their lives. These latter readers may be wrong. Have you ever taken a prescription antihistamine such as Seldane or Allegra? Perhaps got over motion sickness with a compound that included promethazine? If so, your life has been affected by research into antipsychotics. As with so many other areas of research in psychotropic medication, antipsychotics and theories about their use have been developed through combined scientific effort, clinical research, market-driven agendas, and serendipity. Let's look at some history to introduce this topic. The primary source for the following is Healy (2002).
THE CURRENT IMPACT OF ANTIPSYCHOTICS
In a video designed for psychiatrists (Novartis Pharmaceuticals, 1998), a young man suffering from treatment-resistant schizophrenia is shown in an inpatient setting. Although his psychotic symptoms are temporarily under control, he is so incapacitated by medication side effects that he can barely walk across a small room. His movements are jerky contractions of muscle groups that he can hardly control. Anyone who has treated clients taking conventional antipsychotic medications knows that this young man is living a worst-case scenario in which the treatment is worse than the disorder being treated. The video progresses, showing the young man at monthly intervals as he is slowly weaned off the medications causing the side effects, and gradually titrated onto a new medication (clozapine). With each passing month, we see that the young man's psychotic symptoms remain under control but that he is gradually regaining control of his body. In the final video frame, we see the same young man enjoying a game of basketball and apparently having no problems with movement or symptoms of psychosis.
This was one of the first videos promoting what we describe later as an atypical antipsychotic, and at the time of their development most of us believed that clozapine and drugs modeled after its molecular structure launched another revolution in psychopharmacology. It was hoped that (as was hoped in the SSRI revolution in antidepressants) the new antipsychotics would change the way psychotic disorders are treated as well as the quality of life that patients can expect during treatment. As we will see, although newer agents do work better for some but not all people with schizophrenia, the newer agents have problematic side effects similar in impact (if different in quality) as the older agents. Also, the claims that newer medications worked better than the older ones now seem to be untrue ( Jones et al., 2006; Lieberman et al., 2005).
This chapter is divided into seven sections. The first is an overview of schizophrenia and the spectrum of symptoms being treated. The second focuses on th.
Diversity on Wall Street: Where are the women decision makers?Stacey Troup
a case study on the failure of Wall Street to vastly recognize women as viable solutions to portfolio management and other high-profile positions that are predominantly held by men.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Schizophrenia 2
This Week 5 Final Exam paper on schizophrenia will cover different aspects of
schizophrenia including range of impairment, implications on society and treatment options.
This topic was chosen following inspirational lectures in previous weeks given by Elyn Saks,
Associate Dean at the University of Southern California (USC). Having been diagnosed with
schizophrenia during her college years, she struggles daily with the condition yet manages to
hold a highly coveted position while educating others on the condition she, herself, suffers from.
Range of Impairment
As we begin to examine schizophrenia, knowing what types of symptoms present in the
condition and the impact they have on the people who suffer from the condition is an important
first step.
While symptoms vary between participants, some of the more common impairments
include delusions, hallucinations, disorganized thinking, extremely disorganized or abnormal
motor behavior and negative symptoms. (Mayo Clinic Staff, NA)
Delusions
Affecting 4 out of 5 people who are diagnosed with schizophrenia, this condition causes
confusion between thought and reality. It can vary in its context but causes a split of sorts in the
ability to decipher fact from fiction in their reality/everyday life. (Mayo Clinic Staff, NA)
Hallucinations
Another condition which interferes with reality is that of experiencing hallucinations.
Seeing things or people that are not there or hearing voices are common among participants.
Hearing voices is by far the most common hallucination among patients. (Mayo Clinic Staff,
NA)
3. Schizophrenia 3
Disorganized Thinking
Disorganized thinking is a condition whereby sentences or words are put in to order that
make little or no sense. This can cause impairment in the ability to communicate effectively
with others. Mixed thoughts put into sentences seem to make sense to the person speaking them
but appear discombobulated to the recipient. (Mayo Clinic Staff, NA)
Disorganized Motor Behavior
This can be the most difficult symptom to diagnose. Starting in childhood it can consist
of things like resistance to follow instructions, inappropriate and/or bizarre posture, complete
lack of response and useless or excessive movement. (Mayo Clinic Staff, NA)
Negative Symptoms
This symptom refers to the “reduced ability or lack of ability to function normally.”
(Mayo Clinic Staff, NA) This can include things like failure to make eye contact when speaking
to someone, lack of emotion or facial expressions, speech lacking tone or emotion and lacking
hand or head movements considered normal for emotional emphasis of a statement during
conversation. In addition to these social issues, the person can also experience a lack of interest
in things they once took an interest in, hygiene issues and finally, lack of ability to experience
pleasure. (Mayo Clinic Staff, NA)
Age Based Symptoms
While conditions typically begin to show in men during their early to mid 20’s and
women in their late 20s, teens are often affected by symptoms of the condition. (Mayo Clinic
Staff, NA)
Symptoms in teenagers can include things like withdrawal from friends and family, drop
in performance at school, trouble sleeping, irritability or depressed mood and lack of motivation.
4. Schizophrenia 4
However, compared to their same sex elders, teens are less likely to experience delusions but are
more likely to experience hallucinations. (Mayo Clinic Staff, NA)
Impairments – Thoughts
Keeping in mind that symptoms vary between different people, cognitive impairments
affect up to 75% of patients. Memory, attention, motor skills, executive function and
intelligence are all affected by the condition in some way or another. Suicidal thoughts or
actions often accompany onset of symptoms and it is important to seek professional help or
admit the patient into an emergency room for the safety of themselves and those around them.
(O'Carroll, 2000)
Social Implications
Schizophrenia can be costly to families and those afflicted with the condition. According
to a 2002 study, costs were “estimated to be $62.7 billion, with $22.7 billion excess direct health
care cost ($7.0 billion outpatient, $5.0 billion drugs, $2.8 billion inpatient, $8.0 billion long-term
care)”. (Schizophrenia Facts and Statistics, NA)
With state hospitals closing, more prisons are filled with people who have committed
crimes during the onset of a schizophrenic symptom outburst and belong rather in hospitals
where they can become medicated and treated rather than in the prison system. The United
States has failed the mentally ill residents of the country through the closure of these facilities
and forcing these people into dangerous hospitals where they are likely put into seclusion,
shackled and mistreated.
In addition to the medical costs associated with this condition, these patients are rarely
able to work and must be upheld through social service programs such as Medicare for
sustainable living solutions (food, housing, insurance). (Schizophrenia Facts and Statistics, NA)
5. Schizophrenia 5
Causes
It is thought that schizophrenia is brought on through stresses during pregnancy which
contribute to (or trigger) the condition. In addition, it is widely thought that genetic
predispositions are responsible for the onset of the condition. Identifying specific gene
misalignments during pregnancy may assist in the prevention of the condition as science furthers
its research. (Schizophrenia Facts and Statistics, NA)
Treatments
Treatments for this condition vary (or have varied) through the ages. During the middle
ages, causes for schizophrenia were thought to be witchcraft or demonic possession and
therefore, exorcisms were performed to help rid the patient of the symptoms. (Korn, N.A.) In
10,000 B.C., medical practitioners would bore holes into the skulls of patients to release the evil
spirit from the bodies (believing as well that the condition was the result of demonic possession).
(Lobotomy)
In 1934, ECT (electronic convulsive therapy) was introduced. This practice has come
under fire due to the method used for administration of the ECT therapy, including a lack of
patient’s rights, loss of memory and fractured or broken bones from lack of proper methods to
secure the patient before administration of the ECT. These improper treatments have led to
numerous deaths in patients. (Tartakovsky, N.A.)
Pharmaceutical therapies were introduced by a team of French scientists in the 1950’s.
Major drug advancements and scientific research has improved the strains of these drugs to assist
with the offset symptoms as well as improve quality of life have been introduced since that initial
introduction in the 50’s. (Korn, N.A.)
6. Schizophrenia 6
Frontal lobotomy was introduced in 1936 by psychiatrist Walter Freedman. He
performed his first lobotomy for the purpose of alleviation of psychological symptoms on
January 17, 1946. His procedure led to more than 2500 lobotomy’s being performed by the
physician including the lobotomy of a 12 year old boy. Dr. Freedman was banned from the
medical practice and from performing such procedures as lobotomies in 1967 due to insufficient
medical treatment following the procedure. (Tartakovsky, N.A.)
The U.S. leads the world in lobotomies performed (around 50,000) between the late
1940’s and early 1950’s. Several countries have banned the procedure as inhumane and the ban
on this procedure continues in countries today. Within the U.S., certain states have banned the
procedure but it is not widely banned. (Lobotomy)
Modern Treatments
Antipsychotics have been often prescribed to help with the symptoms of schizophrenia.
(Korn, N.A.) Along with antipsychotic medication therapies is in-patient or out-patient therapy,
behavioral therapy, and constant monitoring. It is important to remember that not all APD
(antipsychotic drugs) are the same. (Luh, 2003) Different APD’s have different receptive
binding agents that offer different results. By grouping these medications into one class or
referring to them as the same types of medications can be dangerous to the patient and have
adverse reactions to the patient. (Luh, 2003)
In recent years, a drug called Ivega® Sustenna® has been introduced. (Invega Sustenna -
Information, NA) This drug is part of a family of drugs referred to as atypical antipsychotics and
is administered via a shot in a psychiatrist’s office once a month. (Invega Sustenna -
Information, NA) This family of drugs is still under great debate among medical professionals
because of the side effects which aren’t being discussed.
7. Schizophrenia 7
This drug is designed to alleviate symptoms such as hallucinations and voices and return
the patient to a more normal existence. (Invega Sustenna - Information, NA) However, when
you have a patient who is used to solitude and their only friends are the voices in their head, what
happens when you take the voices away? The result we may experience is a significant increase
in suicidal thoughts and actions. The destitute nature of the solitude the patient is now
experiencing is so depressing to them that they often have nothing left in their lives worth living
for. By way of comparison, it would be like someone dropping you in the middle of a deserted
island with no friends or anyone around you. The loss you would feel would cause a great
depression and likely lead to suicide.
Suicide rates are at an alarming level among patients diagnosed with schizophrenia.
(Limosin, Lozec, Casadebaigd, & Rouillonc, 2007) According to a 1993 study which included
vital statistic data of schizophrenic patients over a 10 year period, an alarming 53.9% of patients
had committed suicide. In addition to these high rates, it was also determined that of first year
diagnosed patients exhibited at 31.8% suicide rate. (Limosin, Lozec, Casadebaigd, & Rouillonc,
2007) Statistics such as these make you wonder if the shot that is available to patients is really
worth the risk. With an already high suicide rate, I would be curious to see what clinical data
experiences in another 10 years as to the rate of suicide among patients who received these shots.
Some therapists and doctors believe that behavioral therapies, in addition to medication,
will help with auditory hallucinations and subsequent symptoms. (Buccheri, Trysgstad, Dowling,
Hopkins, & White, 2004) A 1997 study determined that 25-30% of patients had little or no
positive response to antipsychotic medications in an attempt to alleviate their auditory
hallucinations. Behavioral therapies were given to patients to help alleviate both the auditory
symptoms and the resulting symptoms of schizophrenia, including anxiety and depression.
8. Schizophrenia 8
(Buccheri, Trysgstad, Dowling, Hopkins, & White, 2004)Patients in this study exhibited a 40%
improvement in both hallucinations and the underlying symptoms of anxiety and depression
through the use of both medication and behavioral therapies in conjunction with each other.
(Buccheri, Trysgstad, Dowling, Hopkins, & White, 2004)
When we look at the costs on a worldwide basis, we can see that the U.S. is significantly
behind in its costs associated with treating schizophrenia. (Mangalore, Judit, & Napp, 2004).
Without information relating to the increase of costs vs the implementation of a national health
plan (such as exists in Canada), we are less able to render this data to determine the true position
the U.S. is in comparitively to other countries and the true costs. Could our position in costs be
related to our unwillingness to treat these patients but rather put them behind prison walls? Only
proper data will compel these true results.
Conclusion
With schizophrenia come a lot of confusion, fright and lack of education for the people
around the patient. We have all seen someone walking down the street talking to themselves and
been afraid of how they might react to us if we get too close. The U.S., through its closures of
nearly all government funded psychiatric wards, has effectively pushed these people out on to
the streets. They commit crimes they are unknowing of committing due to their symptoms and
end up in the most inhumane conditions while incarcerated.
If the U.S. would examine the cost of preventative care and that of hospitalizations under
the new Obama Care Act (requiring everyone to have insurance of some sort in the U.S.) and
requiring the Medicare and Medicaid plans to cover these conditions could greatly reduce the
number of homeless, institutionalized and otherwise lost members of our society who may be,
9. Schizophrenia 9
one day, returned to being a productive member of society if we just gave them the opportunity
to get well rather than jump to conclusion and incarcerate them.
While this condition is brought on usually at a young age, some symptoms can be
confused for normal childhood issues and defiance related teen behavior. It is important that if
you suspect tendencies of schizophrenia in children that you get them help immediately. With
the use of a 24 hour psych hold (for observation) you may end up saving a life rather than blindly
looking another direction.
Dr. Elyn Saks has proven that through the loving support of family and the proper
medication combined with hospital stays (as needed) one can lead a productive (or in her case, a
better than productive) life. It is important that these people have the loving support of family
and friends and accept the inpatient therapies and medications as needed. Stressing maintenance
of medication rather than avoidance and combining these medications with behavioral therapies
can present a winning combination to alleviate symptoms and return the patient to a non-
dangerous status in their condition.
Let’s turn a blind eye no more, let’s do something about the status in our country and
demand that facilities be built to assist these patients with their recovery.
10. Schizophrenia 10
References
Buccheri, D. R., Trysgstad, D. R., Dowling, P. R., Hopkins, M. R., & White, F. M. (2004).
Presistent Auditory Hallucinations in Schizophrenia. Journal of Psychosocial Nursing & Mental
Health Services , 42.1, pp. 18-27.
Green, M. F., & Horan, W. P. (2010). Social Cognition in Schizophrenia. Current Directions in
Psychological Science , 19 (4), 243-248.
Invega Sustenna - Information. (NA). Retrieved 07 25, 2015, from Invega Sustenna:
http://www.invegasustenna.com/about-invega-sustenna
Korn, M. M. (N.A.). Historical Roots of Schizophrenia. Retrieved 07 25, 2015, from Medscape:
http://www.medscape.org/viewarticle/418882_6
Limosin, F., Lozec, J.-Y., Casadebaigd, F., & Rouillonc, F. (2007). Ten-year prospective follow-
up study of the mortality by suicide in schizophrenic patients. Elseiver Schizophrenia Research ,
94 (1-3), pp. 23-28.
Lobotomy. (n.d.). Retrieved 07 25, 2015, from Wikipedia:
https://en.wikipedia.org/wiki/Lobotomy
Luh, J. Y. (2003). Atypical antipsychotic drugs for schizophrenia. Mayo Clinic Proceedings , 78
(3), pp 381-382.
Mangalore, R., Judit, S., & Napp, M. (2004). The Global Costs of Schizophrenia. Schizophrenia
Bulletin , 30 (2), pp 27-293.
Mayo Clinic Staff. (NA). Schizophrenia Symptoms - Diseases and Conditions. Retrieved 07 25,
2015, from Mayo Clinic: http://www.mayoclinic.org/diseases-
conditions/schizophrenia/basics/symptoms/con-20021077
O'Carroll, R. (2000). Cognitive impairment in schizophrenia. Advances in Psychiatric Treatment
, 6 (3), 161-168.
Schizophrenia Facts and Statistics. (NA). Retrieved 07 25, 2015, from Schizophrenia.com:
http://www.schizophrenia.com/szfacts.htm
Tartakovsky, M. M. (N.A.). The Surprising History of Lobotomy. Retrieved 07 25, 2015, from
Psych Central: http://psychcentral.com/blog/archives/2011/03/21/the-surprising-history-of-the-
lobotomy/