Learn about the different types of sampling systems available for taking representative samples from pharmaceutical and chemical processes.

1. Sampling Equipment

2. Traditional Sampling Issues
• Inefficient sampling procedures can incur unnecessary
costs
• Product wastage (more sample media taken out than needed)
• Purchase of special equipment and clothing for operator
safety
• Inefficient sampling procedures can present health
and safety hazards
• Environmentally unfriendly
• Risk of operator exposure

3. Representative Sampling
• Main objectives
• Obtain true representation of product
• Collect sample with no contamination to sample or process
• Benefits
• Reduction/Prevention of uncontrolled spillages and pollution from
the sampling process (due to controlled sample volume)
• Protection of operator from hot, corrosive, or toxic chemicals
without the need for PPE (personal protective equipment)
• Sample media cost savings from ability to sample specific volume
of product (especially in the case of high value pharmaceuticals,
fine metals, etc.)

4. DDPS Sampling
• Range of solutions available based on level of
containment required
• From simple, manual units to remote, automated systems
• Analysis systems
• Options available for toxic, flammable and corrosive
media
• Systems with all wetted parts
• Various corrosion-resistant materials of construction (PFA,
Hastelloy, etc.)

5. DDPS Sampling
• Range of solutions available based on level of
containment required
• From simple, manual units to remote, automated systems
• Analysis systems
• Options available for toxic, flammable and corrosive
media
• Systems with all wetted parts
• Various corrosion-resistant materials of construction (PFA,
Hastelloy, etc.)
Some industries who
utilize sampling for
quality control:
• Pharmaceutical
• Chemical
• Biotechnology
• Food and Beverage
• Petrochemical

6. Inline Samplers
 Enables representative sampling
direct from process pipeline
– Good option when obtaining a sample
from a vessel is too difficult.
– Ideal for taking a sample between
process steps.
– Alternatively, can be used to monitor
quality of incoming chemicals or
manufactured product.

7. Surface Mounted Samplers
 Representative samples can be
taken from large pipelines or from
the sidewall of vessels.
 Samples can be collected when
the vessel is under complete
vacuum or when the product is too
viscous to use normal dip tube
sampling operations.

8. Vessel Mounted Samplers
– Single - Sample is drawn from vessel
up dip pipe using site vacuum.
– Recirculating - Diaphragm pump
creates vacuum to draw sample up
dip pipe and then recirculates it
through the system.
– Compact Recirculating – engineered
for plant areas with minimal space.
 Three main types of vessel mounted samplers:

9. Recirculation Sampling System
 Vessel mounted recirculating sampler
features the following options
– Permanent or mobile mounting
– PFA/PTFE or Hastelloy C wetted surfaces
– Dosing
– pH
– Temperature

10. Recirculation Sampling Sequence
Draw sample into
enclosed container
Start with Clean System Start pump to circulate
process fluid

11. Recirculation Sampling Sequence (cont’d)
Wash/Flush
inlet loop
Wash/Flush
outlet loop
N2 blowdown/
Dry outlet loop
N2 blowdown/
Dry inlet loop

12. Sampling System Options
 Alternative MOCs
 Safety cabinet
 High temperature designs
 Sample treatment (heating or cooling)
 Various connection types
 Automation

13. Sampling System Options
 Sample dispensing standard options include:
– Hand held bottle - Simple solution for non-toxic
products
– Threaded bottle connector - Most common option,
features integral vent
– Septum-capped bottle assembly - Cap seals bottle
from atmosphere and needle assembly punctures
holes in septum for filling and venting
– Syringe - No bottle is used; instead the sample is
drawn directly from the process and contained within a
borosilicate glass tube within the syringe assembly.

14.  Additional Resources
– Sampling Equipment Webpage
– Sampling System Questionnaire
– Contact Us
– Call 908.317.2585 to speak with a DDPS representative
Thank you