The document summarizes several automated sample management solutions from TTP LabTech including the comPOUND modular vial storage system, comPILER automated store-to-plate processing system, and Lab2Lab automated sample transport system. The comPOUND can store up to 100,000 vials at temperatures from ambient to -20°C and uses pneumatic transport to retrieve and deliver vials. The comPILER connects multiple comPOUND modules and provides automated processing including thawing, reformatting, and arraying of samples on plates with integration to liquid handlers. Lab2Lab uses low-pressure air to transport vials between stations over distances up to 1000m+ to enable automated analysis of samples on instruments.

1. Sample Management Solutions comPOUND / comPILER / Lab2Lab Simon Tullett 7 th May 2010

4. comPOUND Modular Vial Storage

8. comPOUND – Vial Handling Carousel top view Carousel side cut out Turntable pipes Turntable air-lock, clamps vial, reads barcode, then delivers vial Vial retrieved into (or stored from) rack loaded at front of module Carousel aligned to retrieve from (or store to) Through holes create “chimney” for vial to travel through

9. comPOUND – Software

10. comPOUND – Software

11. comPOUND – Software

14. comPANION 121 allows remote delivery of vials from one comPOUND comPOUND – Expansion comPOUND 124 allows remote delivery and arraying of vials from 1 to 4 comPOUND stores

15. comPOUND – Expansion comMOTION allows remote delivery of racks with a capacity of up to 24 racks

19. Some comPOUND Customers

20. comPILER Automated Store to Plate Processing

25. comPILER – Performance Husam Fayez, LabAutomation 2010 Monthly Throughput of Samples Picked

26. comPILER – Performance Husam Fayez, LabAutomation 2010 Annual Throughput of Samples Picked

27. comPILER – Reliability Husam Fayez, LabAutomation 2010 TTP / Agilent Reliability

28. Sample Integrity “ protecting the crown jewels” Protecting The Assets

29. Compound Exposure Plate Storage – Sample Integrity Precipitation Evaporation concentration 0 2 reaction H 2 0 dilution, reaction DMSO hydroscopic Leaching from Plastic Heat accelerated reaction 2X / 10  C Dust contamination Light decomposition

30. Compound Exposure X X X X X X Tube Benefits Leaching from Plastic Heat accelerated reaction 2X / 10  C Dust contamination Light decomposition Evaporation concentration 0 2 reaction H 2 0 dilution, reaction DMSO hydroscopic Precipitation

33. Automated Sample Management Lab2Lab

37. Lab2Lab - Architecture Router Buffer Waste Bin Collection Bin Sender Analyser Receiver L2L s/w L2L Applet L2L HPLC applet

38. Lab2Lab - Installation Local Area Sample Management Preparation Laboratories Preparation Laboratories Analytical Laboratory Control System Analytical Instruments Remote Senders Remote Senders

39. Lab2Lab - Installation Or Wide Area Sample Management 10 - 300m

40. Lab2Lab - Installation Or Very Wide Area Sample Management 300 - 3000m Booster

41. Lab2Lab - Installation Or Exceptionally Wide Area Sample Management > 3000m Booster Booster

42. Lab2Lab – comPOUND QC Using Lab2Lab for comPOUND QC Control System Compound Library Remote Senders Analytical Instruments

43. Lab2Lab - Software System Control Software

44. Lab2Lab - Software Chemist’s Application Software

45. Lab2Lab - Hardware System Components Sender Buffer / Bulk Sender Collection Bin Receiver (Waters / Agilent) Router

48. Sample Management To arrange for a demonstration of comPOUND, comPILER, comPANION or Lab2Lab at TTP LabTech’s HQ in the UK or at one of our participating customer sites throughout the world please contact: [email_address] or [email_address] or Call +44 1763 262626.