This document discusses the roles of regional transportation planning organizations (RTPOs) in megaregion and multi-jurisdictional planning. It outlines challenges faced by RTPOs like limited funding and resources. It also describes opportunities for RTPOs to enhance economic development and transportation across organizational boundaries through a megaregional lens. The document summarizes workshops held in various megaregions to facilitate collaboration on freight, data sharing, and key projects. It poses questions around formalizing megaregional cooperation and measuring progress at that scale.