Injecting insulin in the same site can lead to complications like lipohypertrophy (fat buildup), scar tissue formation, poor insulin absorption, and infection. To avoid these issues, people should rotate injection sites and avoid injecting in the same spot twice within two weeks by following a regular pattern. Signs of complications include redness, pain, swelling or spongy lumps at the injection site.

1. ROTATING INJECTION SITES
If you notice lumps accumulating around the area where you inject insulin, you may need to
change up your injection site. Not rotating your insulin injection or insulin pump sites enough
can lead to complications, but there are simple steps you can take to avoid these.
Consequences of Injecting at the Same Site
 Lipohypertrophy: A build-up of fat cells
from repeated injections at the same site, as
seen in the pictures to the left. These lumps
will feel spongy, and thickening of the skin
at that location often accompanies it.
 Scar tissue: This will feel like a hard
bump at the injection site.
 Poor and/or delayed insulin absorption,
resulting in a time of high blood glucose (hyperglycemia) followed by a time of low blood
glucose (hypoglycemia). This is because scar tissue is not as effective at absorbing insulin as
undamaged skin.
 Infection at the site: Signs include redness, pain or itching, and increased heat at the area.
 Swelling at the site.
To allow proper healing of formed scar tissue, avoid injecting at that area for at least 6 months.
Tips for Rotating Sites and Preventing Infection
1. Using a pattern will make it easier to
remember where you last injected.
The picture to the right gives some
suggestions, but you can use whatever
pattern will be memorable to you.
2. Try not to inject in the same spot
twice in two weeks.
3. Leave 2 inches of space between sites,
and around the bellybutton.
4. Use a new needle every time, and
wash your hands before and after
injection.
5. Inject directly into the skin instead of
through clothing.
6. If you use an insulin pump: change
the infusion set every 2 to 3 days.
7. Regularly inspect the skin where you
inject to catch early signs of infection
and scarring.
You may need to adjust your insulin dose when you move to a new site. Talk to your
dietician about what dose will be right for you.