This document provides an overview of roller pumps used for cardiopulmonary bypass. It discusses the ideal characteristics of blood pumps, the history and evolution of roller pump designs, how roller pumps work by compressing tubing between rollers and a backing plate, different types of tubing materials used, principles of operation and flow determinants, occlusion adjustment, advantages and disadvantages, and alternative pump designs like nonocclusive roller pumps.
EMBOLISM AND FILTERS USED IN CARDIOPULMONARY BYPASSGLORY MINI MOL. A
FILTERS USED IN CARDIOPULMONARY BYPASS
EMBOLISM
DEFINITION: obstruction of an artery, by a clot of blood or an air bubble.
This emboli is categorized to
Biological emboli
Foreign emboli
Gaseous emboli
There are current technologies to decrease this embolic event delivered to patient
Membrane oxygenators
FILTER
Blood surface coating
Bubble traps
Emboli detection system
Blood Filters
Depth filters
Consist of packed fibers of Dacron wool or
polyurethane foam .
No defined pore size
These filters have large wetted surface
areas to filter the blood by absorption , they are effective in
trapping gross bubbles.
Screen filters
composed of a woven
mesh of polyester fibers
defined pore sizes
From 20 -40 μm
(all of the arterial line filters used are the screen type)
EMBOLISM AND FILTERS USED IN CARDIOPULMONARY BYPASSGLORY MINI MOL. A
FILTERS USED IN CARDIOPULMONARY BYPASS
EMBOLISM
DEFINITION: obstruction of an artery, by a clot of blood or an air bubble.
This emboli is categorized to
Biological emboli
Foreign emboli
Gaseous emboli
There are current technologies to decrease this embolic event delivered to patient
Membrane oxygenators
FILTER
Blood surface coating
Bubble traps
Emboli detection system
Blood Filters
Depth filters
Consist of packed fibers of Dacron wool or
polyurethane foam .
No defined pore size
These filters have large wetted surface
areas to filter the blood by absorption , they are effective in
trapping gross bubbles.
Screen filters
composed of a woven
mesh of polyester fibers
defined pore sizes
From 20 -40 μm
(all of the arterial line filters used are the screen type)
Cardiopulmonary bypass development and history
Indication of cpb
Hardware in cpb
Arterial and venous cannulation
Oxygenator
Heat exchanger
Filter
How to conduct cpb and problems in cpb
Cardioplegia
Cardiopulmonary bypass development and history
Indication of cpb
Hardware in cpb
Arterial and venous cannulation
Oxygenator
Heat exchanger
Filter
How to conduct cpb and problems in cpb
Cardioplegia
Introduction, classification, principle of working and constructional details of vane pumps, gear pumps, radial and axial plunger pumps, screw pumps, power and efficiency calculations, characteristics curves, selection of pumps for hydraulic Power transmission.
Reexpansion pulmonary edema is a serious complication after sudden expansion of collapsed lung.Re-expansion pulmonary edema is an uncommon complication following drainage of a pneumothorax , pleural effusion or removal of any space occupying lesion.
The incidence referred is less than 1%, andmortality can reach up to 20%.
Myocardial protection in redo surgery with patent left internal mammary arteryVijay Anand
Myocardial protection in redo surgery with patent left internal mammary artery. various technique described in literature was discussed a with 2 case report which we operated
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. Ideal characteristics of blood pump
Types of Blood Pumps
Roller pump
History
Structure – tubing
Types of roller pump
Principles of operation & Flow determinants
Adjustment of occlusion
Advantages / disadvantages
Various types in use
Nonocclusive roller pump
3. move large volumes of blood (up to 7 L/min)
against significant pressures (perhaps up to 500
mm Hg proximal to the arterial cannula)
pump should minimize flow velocity so that
damage to the blood is minimized
should not damage the blood cells and should
not activate either the inflammatory or
coagulation cascades
4. Design should be simple and free from dead
spaces and recesses to avoid stagnation and
turbulence.
Calibration of the pump should be easy,
reliable, and reproducible.
The pump should be automatically controlled
and operated for routine use,
designed for possible manual operation in case
of power failure
6. This type of pump moves blood forward by
displacing the liquid progressively, from the
suction, to the discharge opening of the unit
7. Use rollers along flexible tubing to provide the
pumping stroke and give direction to the flow
This type of positive displacement pump can be
set to provide pulsatile or non-pulsatile
(laminar) flow.
9. In 1887, Allen patented a pump designed for
blood transfusion
In 1934, DeBakey et al. made a modification to
the Porter-Bradley infusion pump to prevent
creepage of the latex rubber tubing during
blood transfusion. added a flange to the outer
circumference of the tubing, which was then
clamped into the housing
1959, Melrose proposed a more advanced
design, in which the roller ran along the tubing
held in place by a grooved backplate
10.
11. • Roller pumps contain a length of tubing located inside a
curved raceway
• This raceway is placed at the travel perimeter of rollers
mounted on the ends of rotating arms
• These arms are arranged in such a manner that one
roller is compressing the tubing at all times.
12. Three basic materials currently used for tubing:
• silicone rubber,
• latex rubber, and
• polyvinyl chloride (PVC)- most widely used (durability
and acceptable hemolysis rates)
13. • Hemolysis
Latex rubber > PVC > silicone rubber
• PVC tubing stiffens during hypothermic CPB and tends to
induce spallation,. Silicone rubber > PVC
14.
15. • Because one of the two rollers is always compressing the
tubing, the double-roller pump generates a relatively
nonpulsatile flow.
• Debate over the advantages and disadvantages of non-
pulsatile or pulsatile perfusion during cardiopulmonary
bypass still continues
16. roller pump causes blood to flow by compressing
plastic tubing between the roller and the
horseshoe-shaped backing plate as the roller turns
in the raceway
Flow from a systemic roller pump is linear with
rpm
The stroke volume, or output in milliliters per
rpm, of a roller pump can vary slightly depending
on tubing material, elasticity, or temperature but
generally ranges from 12.7 (1/4-inch ID tubing) to
41.9 mL (1/2-inch) when using a 6-inch dual roller
pump
17.
18. A. pump head and tubing diameter,
B. roller RPM, and
C. length of tubing in contact with the rollers
Roller pumps are relatively independent of
circuit resistance and hydrostatic pressure
19. Forward or retrograde flow of blood can be
achieved by altering the direction of pump
head rotation; thus roller pumps are commonly
used as the primary arterial flow pump as well
as for suction of blood from the heart and
mediastinal cavity during CPB to salvage blood
, to deliver cardioplegic solution
20. Roller pumps require occlusion adjustment for
optimum function and avoidance of hemolysis
and activation of leukocytes and platelets
Occlusion - separation between the rollers and
the backing plate (or raceway)
Total occlusion is not used
Excessive compression aggravates hemolysis
and tubing wear; too little occlusion may also
aggravate hemolysis
21. holding the distal systemic flow line, which is
primed with clear fluid, vertically so that the
top of the fluid column is 30 to 40 inches above
the pump. The occlusion is adjusted until the
fluid level falls at a rate of 1 inch/min.
22. ALTERNATIVE
METHODS
• (i) clamping the outlet tubing from the roller pump
and slowly advancing the rollers to pressurize fluid
within the line, stopping the pump, and then
adjusting the occlusion until a slow decline in
pressure monitored distal to the pump head is
observed; and (ii) clamping the distal tubing and
adjusting the occlusion while slowly rotating the
pump head so as to maintain pressure in the tubing
greater than that anticipated during CPB (e.g., 300
to 400 mm Hg); this method requires a valved shunt
between the outlet and inlet tubing of the pump
23. For suction or vent pumps, the occlusion is set
by clamping the tubing on the inlet side of the
roller pump and gradually occluding the
rotating rollers until tubing within the pump
head just collapses.
When occlusion is properly set, the pump flow
rate does not significantly decrease as the
afterload (arterial pressure) increases
25. Out put is accurate because it is not dependent of the
circuits resistance (including the patients resistance)
Occlusive, therefore if power goes out the arterial line
won’t act as a venous line
26. malocclusion (over- or underocclusion),
miscalibration,
fracture of the tubing,
"runaway" pumping ,
loss of power,
spallation, and
the capacity to pump air(Cavitation)
High RPM and fully occlusive settings tend to
promote blood damage
27. which refers to the release of plastic
microparticles from the inner wall of tubing as
a result of roller pump compression
28. sudden occlusion of the inflow to the pump, as a result of low
circulating volume or venous cannula obstruction, can result in
“cavitation,” the formation and collapse of gas bubbles due to the
creation of pockets of low pressure by precipitous change in
mechanical forces.
pressure-regulated shunt between the outflow and inflow lines of
the roller pump
However, this usually does not occur because the tubing that
enters the roller pump is short and is connected directly to a
reservoir that contains enough blood to preclude development of
significant negative pressure
29. Rawn et al. found no difference in hemolysis
between a roller pump with a standard set
occlusion and a centrifugal pump at a 4.5-
L/min blood flow rate with an afterload of 250
mm Hg. When the occlusion is opened such
that pumping at 5 rpm against occluded tubing
maintains a pressure of 150 to 225 mm Hg, the
roller pump induces less hemolysis than a
centrifugal pump
30. Advantages
Power leads accessible from front
Easy to operate alarm status
Delayed reversing
Clutchable hand cranking
Easy to wheel
Can hand crank with lids closed
Alarm status turns off both main
& cardioplegia
Sarns 8000
Disadvantages
• Hinge occlusion mechanism - not as
secure as COBE
• Bulky
• Tilted operating panels (if spill)
• Individual collars
31. Advantages
Compact design
Easy to operate alarm status
Difficult to wheel
Disadvantages
Difficult to access power outlets
Computer configuration - difficult to control
Non clutchable cranking
Lids must be open to crank
COBE
32. Advantages
Rotating head turrets
Disadvantages
Difficult to control alarms
Flat control surface - poor spill control; items
could be dropped directly on & damage
Opaque pump covers - difficult to see
Preloading tubing line inserts (had to be
initially removed)
Stockert
33. Advantages
Fully computerised - downloads everything
Fully automated everything
Runs from transformer- not so subject to
current surges [converts AC to DC]
Universal collars
Disadvantages
More complex to operate?
Unique operating procedures – non
intuited
During failures - requires codes to be
switched into manual override
Non modular design - if base fails (or
computer system) the whole system goes
down
Gambro/Jostra
34. Flat compliant tubing is fitted under tension over the
rollers.
Nonocclusive roller pumps require positive pressure at
the inlet to fill the tubing as the rollers turn.
Macroair emboli are unlikely.
Nonocclusive roller pumps require use of an in-line
flowmeter
Nonocclusiverollerpumps
35. Metaplus pump is a new type of
blood pump that appears to
incorporate some advantages of a
centrifugal pump while minimizing
some disadvantages of a
conventional roller pump
This pump will not drain the
venous reservoir, will not create
negative pressure and cavitation,
will not overpressurize, and will
not allow retrograde flow
Metaplus pump
36. Forward fluid flow is accomplished
by a passive-filling tapered
pumping chamber fabricated of
two sheets of flat polyurethane
tubing bonded at the edges
pump chamber segment is
stretched under tension over three
rollers.
no backing plate against which the
tubing can be compressed with
rollers.
The rollers are mounted on a rotor
that spins to impart a peristaltic
action on the fluid within the
pump chamber
priming volume is 120 mL
37.
38. 1. LeGallois JJC. Experiments on the Principle of
Life (tr. by NC and JC Nancrede). Philadelphia,
M. Thomas, 1813.
2. von Frey M, Gruber M. Untersuchungen uber den
stoffwechsel isolierter organe. Ein respirationsapparat
fur isolierte organe. Arch f Physiol (Leipz.)
1885; 9:519.
3. Gibbon JH. Artificial maintenance of circulation
during experimental occlusion of pulmonary
artery. Arch Surg 1937; 34:1105.
4. Gibbon JH. Application of a mechanical heart
and lung apparatus to cardiac surgery. Minn Med
1954; 37:171.
5. Andreasen AT, Watson F. Experimental cardiovascular
surgery. Brit J Surg 1952; 39:548.
6. Andreasen AT, Watson F. Experimental cardiovascular
surgery: Discussion of results so far
obtained and report on experiments concerning
donor circulation. Brit J Surg 1953; 41:195.
7. Lillehei CW. Controlled cross-circulation for
direct-vision intracardiac surgery: Correction of
ventricular septal defects, atrioventricularis
communis and tetralogy of Fallot. Postgrad Med
1955; 17:388.
8. Lillehei CW, Cohen M, Warden HE, Read RC,
Aust JB, DeWall RA, Varco RL. Direct vision
intracardiac surgical correction of tetralogy of
Fallot, pentalogy of Fallot and pulmonary atresia
defects. Report of first ten cases. Ann Surg 1955;
142:418.
9. Dale HH, Schuster EA. A double perfusion
pump. J Physiol (London) 1928; 64:356.
10. Galletti PM, Brecher GA. Heart-Lung Bypass:
Principles and Techniques of Extracorporeal
Circulation. NewYork, Grune & Stratton, 1962.
11. Beck A. Zur Technik der bluttransfusion. Klin
Wschr 1924; 2:1,999.
12. Issekutz BV. Beitrage zur wirkung des insulins.
I. Insulin-Adrenalin Antagonismus. Biochem
Ztschr 1927; 183:283.
13. Bayliss WM, Muller EA. A simple, high speed
rotary pump. J Scient Instrum 1928; 5:278.
REFERENCE
scavenger for the cleaning of privies, as a
stomach pump, and as an apparatus for injections.
With larger ID tubing (e.g., 1/2-inch ID), lower rpm are required to achieve the same output
compared to smaller ID tubing.
The principle of the roller pump is demonstrated by the hand roller in the lower drawing moving along a section of tubing pushing fluid ahead of it and
suctioning fluid behind it.
Occlusion can be adjusted by either increasing or decreasing the compression of the tubing by the rollers
Because of this, high
pressures can quickly develop in the CPB systemic flow line if the arterial
cannula is blocked as a result of either tube kinking or a tubing clamp
Operating principle of the triple-roller pump and pumping chamber. Polyurethane pumping chamber is
stretched over the rollers, and roller rotation is counterclockwise. E-E: Cross-sectional view of pumping
chamber distended when blood is supplied at a pressure above ambient. B: Pumping chamber inlet collapsed
when blood is not supplied at a pressure above ambient. F-F: Cross-sectional view of the collapsed pumping
chamber