This document provides instructions for setting up and operating a Roland MDX-540 4-axis CNC mill. It describes how to set up the machine coordinates, secure a workpiece for 4-axis milling, change endmills, set the Z-origin, and post NC code to begin milling. The setup process involves defining the A, Y, X and Z coordinate systems, calibrating the Z-origin sensor, and ensuring the material matches the 3D model. Safety steps are outlined and virtual panel navigation is illustrated with screenshots.