Rheumatic fever is an inflammatory disease that occurs as a delayed reaction to a Group A streptococcal throat infection. It most commonly affects children between 5-18 years old. The main manifestations include arthritis, carditis, chorea, and less commonly subcutaneous nodules and erythema marginatum. It is diagnosed using the revised Jones criteria which requires evidence of a preceding streptococcal infection and either two major manifestations or one major and two minor manifestations. Treatment involves primary prevention through antibiotic treatment of streptococcal infections, anti-inflammatory treatment such as aspirin for arthritis and steroids for carditis, supportive management of complications, and long-term secondary prevention through antibiotic prophylaxis.
Rheumatic fever (acute rheumatic fever) is a disease that can affect the heart, joints, brain, and skin.
Rheumatic fever can develop if strep throat and scarlet fever infections are not treated properly.
Early diagnosis of these infections and treatment with antibiotics is key to preventing rheumatic fever.
Rheumatic fever (acute rheumatic fever) is a disease that can affect the heart, joints, brain, and skin.
Rheumatic fever can develop if strep throat and scarlet fever infections are not treated properly.
Early diagnosis of these infections and treatment with antibiotics is key to preventing rheumatic fever.
Acute rheumatic fever-definition,pathophysiology,clinical presentation and ma...onlinefreelancer1
A detailed approach to ACUTE RHEUMATIC FEVER,based on Harrison Principles of internal medicine and Braunwald Textbook of Cardiology.Useful for post graduate seminars.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
2. INTRODUCTION
Rheumatic fever is an immunologically mediated inflammatory disease, that occurs as a delayed
sequel to group A streptococcal throat infection, in genetically susceptible individuals.
Chronic rheumatic heart disease remains an important public health problem in developing
countries.
In developing areas, the prevalence is about 24 per 1000.
Rheumatic fever occurs most frequently among children and adolescents between 5 and 18
years, coinciding with the age distribution of the highest prevalence of streptococcal infections.
Risk Factors: Poverty, overcrowded living conditions.
3. PATHOGENESIS
After GAS infection of the pharynx, neutrophils, macrophages and dendritic cells
phagocytose bacteria and present antigen to T cells.
Both B and T cells respond to the GAS infection, initially by antibody production (IgM and
IgG) and subsequently through T cell activation (mainly CD4+ cells).
In susceptible individuals, the host response against GAS will trigger autoimmune reactions
against host - a process called molecular mimicry.
Molecular mimicry is the sharing of antibody or T cell epitopes between the host and the
microorganism.
In the case of ARF, these host antigens are located in tissues such as the heart and the brain.
6. CLINICAL MANIFESTATIONS
There is a latent period of ~3 weeks (1-5 weeks) between the precipitating
group A streptococcal infection and the appearance of the clinical features
of ARF.
Common Clinical Features:
Arthritis (present in 60-80% of cases)
Carditis (50-60%)
Chorea (<2- 30%)
Erythema marginatum and subcutaneous nodules (<5% of cases)
7. ARTHRITIS
Most common manifestation.
It usually affects the peripheral large joints; knees, ankles, elbows and wrists are
the most frequently affected.
In addition to arthralgia, the joints are red, warm and swollen.
Arthritis is characteristically asymmetrical, migratory, and very painful, although
some patients may present mild joint complaints.
It usually resolves spontaneously at the most in 2 or 3 weeks.
Arthritis in ARF has an excellent response to salicylates
8. CARDITIS
It is a pancarditis, but valvular involvement is the rule.
The commonest involved valve is the mitral, frequently associated with aortic valve involvement.
On pathological examination, the valves are thickened and display rows of small vegetations
(Aschoff body) along their apposing surfaces.
The clinical picture includes high pulse rate, congestive heart failure, arrhytmias and pericardial
friction rubs.
Murmurs:
Valvulitis – low pitched mid diastolic murmur at apex (Carey Coombs)
Mitral regurgitation – mid frequency pansystolic murmur
Aortic regurgitation – high pitched decrescendo diastolic murmur.
Cardiomegaly on CXR and Echocardiogram.
10. SYDENHAM‘S CHOREA
Characterized by involuntary movements, specially of the face and limbs, muscle weakness,
disturbances of speech and gait.
Children usually exhibit concomitant psycologic dysfunction, especially obsessive-compulsive
disorder, increased emotional lability, hyperactivity, irritablility and age-regressed behaviour.
It is usually a delayed manifestation, and is often the sole manifestation of ARF.
However, chorea may occur in association with other major manifestations of RF, particularly
in the first attack.
Most of the patients experience resolution of the symptomatology after a few months.
11. SUBCUTANEOUS NODULES
Subcutaneous nodules are rarely seen
and when present, they are usually
associated with severe carditis.
They are painless, firm, movable,
measuring around 0.5 to 2 cm.
They are usually located over extensor
surfaces of the joints, particularly
knees, wrists and elbows.
12. ERYTHEMA MARGINATUM
This is an evanescent,
erythematous, non-pruritic rash
with pale centers and rounded or
serpiginous margins.
Lesions occur mainly on the trunk
and proximal extremities and may
be induced by application of heat
13. DIAGNOSIS
With the exception of Sydenham's chorea, which has a latency period of
several months, the clinical manifestations of acute RF present after about
3 weeks following the streptococcal throat infection.
It usually begins with nonspecific symptoms, such as fever, malaise and
persistent pallor.
Diagnosis is based on the revised Jones Criteria.
Arthritis, carditis, chorea, and less frequently, subcutaneous nodules and
erythema marginatum are major manifestations of RF.
14. REVISED JONES CRITERIA
If supported by evidence of preceding streptococcal infection, the presence of two major
manifestations or one major and two minor manifestations indicates a high probability of
acute RF
16. LABORATORY STUDIES
Acute phase reactants are useful in helping to recognize acute RF and also to exclude
other diseases.
C-reactive protein and erythrocyte sedimentation rates are helpful in monitoring
inflammatory activity.
Laboratory evidence of a preceding GAS infection should be sought, either by
demonstration of GAS in the throat by culture or rapid streptoccocal antigen test, or using
streptococcal antibody tests.
Elevated or rising titers of antistreptolysin O (ASO) occur in more than 80% of patients
with acute GAS pharyngitis.
Prolonged P-R interval relative to heart rate is a nonspecific finding.
Cardiac scanning scintigraphy has been shown to be a reliable method distinguishing
acute from chronic, inactive RHD and also in the follow-up of active carditis
20. STEP II: Anti Inflammatory Treatment
Arthritis
NSAIDS - Aspirin
75- 100mg/kg/day, QID for 6 weeks
Attain blood level 20-30mg/dL
Carditis
Corticosteroids – Prednisolone
2- 2.5mg/kg/day, BID for 2 weeks
Taper over 2 weeks, add aspirin 75mg/kg/day for 2 weeks
Continue aspirin alone 100mg/kg/day for another 4 weeks.
21. STEP III: Supportive Management
Bed rest
Treatment of congestive cardiac failure - digitalis, diuretics and vasodilators.
Treatment of chorea
Carbamazepine has also been suggested as a first-line treatment for Sydenham's
chorea.
haloperidol (initial dose of 0.5 to 1mg/kg/day, maximum, 5mg/day)
valproic acid (15-20 mg/kg/day)
Rest to joints & supportive splinting
23. PROPHYLAXIS
WHO GUIDELINES
At least 5 years of prophylaxis or if child until age 18 if not cardiac
involvement.
10 years prophylaxis or if child until age 25 if has mild mitral regurgitation.
Lifelong prophylaxis if has severe valve disease.
24. PROGNOSIS
Rheumatic fever can recur whenever the individual experience new GAS
infection, if not on prophylactic medicines.
Good prognosis for older age group & if no carditis during the initial
attack.
Bad prognosis for younger children & those with carditis with valvar
lesions.
25. REFERENCE
Stollerman GH. Rheumatic fever. Lancet. 1997;349:935–942. [PubMed]
Pomerance A. Cardiac involvement in rheumatic and ‘collagen’ diseases. In: Pomerance A, Davies MJ,
editors. The pathology of the heart. Oxford: Blackwell Scientific Publications; 1975. pp. 279–306.
Denny FW, Wannamaker LW, Brink WR, Rammelkamp CH, Jr, Custer E. A Prevention of rheumatic fever;
treatment of the preceding streptococcic infection. J Am Med Assoc. 1950;143:151–153. [PubMed]
Carapetis JR. The stark reality of rheumatic heart disease. Eur Heart J. 2015;36:1070–1073. [PubMed]
Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds.Harrison's Principles of Internal Medicine,
18e. New York, NY: McGraw-Hill; 2012.