Revision of the Jones Criteria for the Diagnosis of AcuteRheumatic Fever in the Era of Doppler EchocardiographyA Scientific Statement From the American Heart Association
Revision of the Jones Criteria for the Diagnosis of AcuteRheumatic Fever in the Era of Doppler EchocardiographyA Scientific Statement From the American Heart Association
Rheumatic Heart Disease (RHD) is one of the major causes of cardiovascular disease, accounting for nearly 25-45% of the acquired heart disease.
Rheumatic Fever (RF) is a febrile disease affecting connective tissue (heart) & joints. It is caused due to infection of the throat by group-A beta hemolytic streptococci.
It is NOT a communicable disease but results from communicable disease(streptococcal pharyngitis).
RF is the common cause of acquired heart disease in childhood and adolescence.
An acute illness caused by an autoimmune response to infection with group A Streptococcus, leading to a range of possible symptoms and signs affecting any or all of heart, joints, brain, skin and subcutaneous tissues
Rheumatic Heart Disease (RHD) is one of the major causes of cardiovascular disease, accounting for nearly 25-45% of the acquired heart disease.
Rheumatic Fever (RF) is a febrile disease affecting connective tissue (heart) & joints. It is caused due to infection of the throat by group-A beta hemolytic streptococci.
It is NOT a communicable disease but results from communicable disease(streptococcal pharyngitis).
RF is the common cause of acquired heart disease in childhood and adolescence.
An acute illness caused by an autoimmune response to infection with group A Streptococcus, leading to a range of possible symptoms and signs affecting any or all of heart, joints, brain, skin and subcutaneous tissues
Rheumatic heart disease (RHD) remains a major cause of preventable death and disability in children and young adults. Despite significant advances in medical technology and increased understanding of disease mechanisms, RHD continues to be a serious public health problem throughout the world, especially in low- and middle-income countries. Echocardiographic screening has played a key role in improving the accuracy of diagnosing RHD and has highlighted the disease burden. Most affected
patients present with severe valve disease and limited access to life-saving cardiac surgery or percutaneous valve intervention,
contributing to increased mortality and other complications. Although understanding of disease pathogenesis has advanced in
recent years, key questions remain to be addressed. Preventing or providing early treatment for streptococcal infections is the
most important step in reducing the burden of this disease.
Define rheumatic fever.
what are the main causes of rheumatic fever.
List the clinical finding of rheumatic fever.
To list and identify the most commonly used laboratory tests to detect the rheumatic fever.
How to treat rheumatic fever .
To list some of the procedures that are used for the prevention of the rheumatic fever .
Rheumatic fever is quite common in developing countries and it has well known cardiac complications. So it's very important to know rheumatic fever, hopefully, this presentation will fill the needs. If you think it's helpful then share it.
Rheumatic heart disease (RHD) remains a major cause of preventable death and disability in children and young adults. Despite significant advances in medical technology and increased understanding of disease mechanisms, RHD continues to be a serious public health problem throughout the world, especially in low- and middle-income countries. Echocardiographic screening has played a key role in improving the accuracy of diagnosing RHD and has highlighted the disease burden. Most affected
patients present with severe valve disease and limited access to life-saving cardiac surgery or percutaneous valve intervention,
contributing to increased mortality and other complications. Although understanding of disease pathogenesis has advanced in
recent years, key questions remain to be addressed. Preventing or providing early treatment for streptococcal infections is the
most important step in reducing the burden of this disease.
Define rheumatic fever.
what are the main causes of rheumatic fever.
List the clinical finding of rheumatic fever.
To list and identify the most commonly used laboratory tests to detect the rheumatic fever.
How to treat rheumatic fever .
To list some of the procedures that are used for the prevention of the rheumatic fever .
Rheumatic fever is quite common in developing countries and it has well known cardiac complications. So it's very important to know rheumatic fever, hopefully, this presentation will fill the needs. If you think it's helpful then share it.
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OPENWHO PORTAL PRESENTATION ON CORONAVIRUS
At the end of this lecture, you will be able to:•Describe the importance of early recognition of patients with SARI.•Recognize patients with severe pneumonia.•Recognize patients with ARDS.•Recognize patients with sepsis and septic shock.
A mosquito-borne viral disease occurring in tropical and subtropical areas.
Those who become infected with the virus a second time are at a significantly greater risk of developing severe disease.
Symptoms include high fever, headache, rash and muscle and joint pain. In severe cases there is serious bleeding and shock, which can be life threatening.
Treatment includes fluids and pain relievers. Severe cases require hospital care.
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Revision of the Jones Criteria for the Diagnosis of AcuteRheumatic Fever in the Era of Doppler EchocardiographyA Scientific Statement From the American Heart Association
1. Revision of the Jones Criteria for the Diagnosis of
Acute
Rheumatic Fever in the Era of Doppler
Echocardiography
A Scientific Statement From the American Heart
Association
Circulation
Volume 131(20):1806-1818
May 19, 2015
2. Introduction
• Although acute rheumatic fever (ARF) has
declined in Europe and North America in
incidence, the disease remains one of the most
important causes of cardiovascular morbidity
and mortality in the developing countries
• The Jones criteria, used for guidance in the
diagnosis of ARF since 1944, were last modified
by the American Heart Association (AHA) in
1992.
• In the past few years, developments in several
areas have prompted reexamination of the
traditional Jones criteria.
3. • As echocardiographic techniques and
applications, including quantitative Doppler and
color flow mapping, have evolved worldwide
during the past 2 decades, Other national and
regional guidelines for the diagnosis of ARF
have recently included the use of
echocardiography/ Doppler methodologies.
• Numerous studies from a broad range of clinical
circumstances have suggested that there be
more widespread use of echocardiography as a
way to diagnose carditis even in the absence of
overt clinical findings (“subclinical carditis”).
4. Epidemiological Background
• The decline in the incidence of ARF and the
prevalence of RHD has been attributed to
improved hygiene, improved access to antibiotic
drugs and medical care, reduced household
crowding, and other social and economic
changes.
• To avoid overdiagnosis in low incidence
populations and to avoid underdiagnosis in high-
risk populations, variability in applying diagnostic
criteria in low risk compared with high-risk
populations is reasonable.
5. Epidemiological data appear to indicate the
following:
1. It is reasonable to consider individuals to be at low
risk for ARF if they come from a setting or
population known to experience low rates of ARF or
RHD (Class IIa; Level of Evidence C).
2. It is reasonable that where reliable epidemiological
data are available, low risk should be defined as
having an ARF incidence <2 per 100 000 school-
aged children (usually 5–14 years old) per year or
an all age prevalence of RHD of ≤1 per 1000
population per year (Class IIa; Level of Evidence
C).
3. Children not clearly from a low-risk population are
6. Clinical Manifestations of ARF
• Universally, the most common major manifestations
remain carditis (50%–70%) and arthritis (35%–66%)
• These are followed in frequency by chorea (10%–30%),
which has been demonstrated to have a female
predominance, and then subcutaneous nodules (0%–
10%) and erythema marginatum (<6%), which remain
much less common but highly specific manifestations of
ARF
7. Carditis: Diagnosis in the Era of Widely
Available
Echocardiography
• Carditis as a major manifestation of ARF has been a clinical
diagnosis based on the auscultation of typical murmurs that
indicate mitral or aortic valve regurgitation, at either valve or
both valves.
• Although the carditis of ARF has been considered to be a
pancarditis and can involve the endocardium, myocardium,
and pericardium, valvulitis is by far the most consistent
feature of ARF, and isolated pericarditis or myocarditis should
rarely, be considered rheumatic in origin.
• In an era when clinical auscultatory skills may be declining at
the same time that widespread availability of reliable cardiac
ultrasound is increasing, echocardiography is being used
8. • Thus, the concept of subclinical carditis has become
incorporated into other guidelines and consensus
statements as a valid rheumatic fever major manifestation
• Subclinical carditis refers exclusively to the circumstance
in which classic auscultatory findings of valvular
dysfunction either are not present or are not recognized
by the diagnosing clinician but echocardiography/Doppler
studies reveal mitral or aortic valvulitis.
9.
10.
11.
12.
13. The writing group regarding the utility of
echocardiography/Doppler for the evaluation of
cardiovascular status in patients with ARF concludes the
following:
1. Echocardiography with Doppler should be performed in all
cases of confirmed and suspected ARF (Class I; Level of
Evidence B).
2. It is reasonable to consider performing serial
echocardiography/ Doppler studies in any patient with
diagnosed or suspected ARF even if documented carditis is
not present on diagnosis (Class IIa; Level of Evidence C).
3. Echocardiography/Doppler testing should be performed to
assess whether carditis is present in the absence of
auscultatory findings, particularly in moderate- to high-risk
populations and when ARF is considered likely (Class I; Level
of Evidence B).
4. Echocardiography/Doppler findings not consistent with
carditis should exclude that diagnosis in patients with a heart
14. Arthritis
• Typically, as described in the Jones criteria revision of
1992,the arthritis of ARF is a migratory polyarthritis, and the
joints most frequently involved are larger ones, including
knees, ankles, elbows, and wrists.
• A history of rapid improvement with salicylates or
nonsteroidal anti-inflammatory drugs is also characteristic.
Generally, the arthritis in ARF runs a self-limited course, even
without therapy, lasting ≈4 weeks
• Patients with group A β-hemolytic streptococcal infection and
articular disease that does not fulfill the classic Jones criteria
for the diagnosis of ARF are sometimes classified as having
poststreptococcal reactive arthritis/arthralgia, and currently,
there is controversy about secondary prophylaxis for these
patients
15. • Studies from India, Australia, and Fiji have indicated that
aseptic monoarthritis may be important as a clinical
manifestation ARF in selected high-risk populations
• At present, consideration that monoarthritis may be part
of the ARF spectrum should be limited to patients from
moderate- to high-risk populations (Class I; Level of
Evidence C).
• Polyarthralgia is a very common, highly nonspecific
manifestation of a number of rheumatologic disorders.
• The inclusion of polyarthralgia as a major manifestation
is applicable only for moderate- or high-incidence
populations and only after careful consideration and
exclusion of other causes of arthralgia such as
autoimmune, viral, or reactive arthropathies (Class IIb;
16. CHOREA
• Chorea in ARF is characterized by purposeless,
involuntary, non-stereotypical movements of the
trunk or extremities. It often is associated with
muscle weakness and emotional lability.
• Evidence of a recent group A streptococcal
infection may be difficult or impossible to
document because of the long latent period
between the inciting streptococcal infection and
the onset of chorea.
17. SKIN FINDINGS
• Erythema marginatum is the unique, evanescent,
pink rash seen with pale centers and rounded or
serpiginous margins.
• The rash usually is present on the trunk and
proximal extremities and is not facial. Heat can
induce its appearance, and it blanches with
pressure. As with other rashes, erythema
marginatum may be harder to detect in dark-
skinned individuals.
18. • Subcutaneous nodules are firm, painless
protuberances found on extensor surfaces at
specific joints, including the knees, elbows, and
wrists, and also are seen in the occiput and along
the spinous processes of the thoracic and lumbar
vertebrae. They have not been found to have racial
or population variability.
• Nodules are more often observed in patients who
also have carditis, and as with erythema
marginatum, subcutaneous nodules almost never
occur as the sole major manifestation of ARF
19. Other Clinical Features: Minor
Manifestations
• In the 1965 revision of the Jones criteria, the
authors commented that during an episode of
ARF, temperature usually exceeds 38°C, and in
the 1992 revision, that was revised to 39°C.
• A high-risk population, the definition of fever as
a temperature >38°C has resulted in improved
sensitivity, with 75% of individuals with ARF
meeting this criterion compared with only 25%
when a cutoff value of >39°C was used.
20. • Generally, there appear to be no differences in
other minor clinical manifestations (raised C-
reactive protein, erythrocyte sedimentation rate,
prolonged PR interval on ECG, a past history of
rheumatic fever or RHD) between that of low-
and higher-risk populations and geographies.
• For most populations, an erythrocyte
sedimentation rate >30 mm in the first hour and
C-reactive protein >3.0 mg/dL are considered
typical of ARF.
21. Evidence of Preceding
Streptococcal Infection
• Because other illnesses may closely resemble
ARF, laboratory evidence of antecedent group A
streptococcal infection is needed whenever
possible, and the diagnosis is in doubt when
such evidence is not available.
• Exceptions to this include chorea, which may be
the only manifestation of rheumatic fever at the
time of its presentation, and rarely, individuals
with chronic, indolent rheumatic carditis with
insidious onset and slow progression.
22. Any 1 of the following can serve as evidence of
preceding infection, per a recent AHA
statement
1. Increased or rising anti-streptolysin O titer or
other streptococcal antibodies (anti-DNASE B)
(Class I; Level of Evidence B).A rise in titer is
better evidence than a single titer result.
2. A positive throat culture for group A β-hemolytic
streptococci (Class I; Level of Evidence B)
3. A positive rapid group A streptococcal
carbohydrate antigen test in a child whose clinical
presentation suggests a high pretest probability of
streptococcal pharyngitis (Class I; Level of
Evidence B)
23.
24. Rheumatic Fever Recurrences
As stated in the 1992 guidelines, patients who have a
history of ARF or RHD are at high risk for “recurrent”
attacks if reinfected with group A streptococci.
• With a reliable past history of ARF or established RHD,
and in the face of documented group A streptococcal
infection, 2 major or 1 major and 2 minor or 3 minor
manifestations may be sufficient for a presumptive
diagnosis (Class IIb; Level of Evidence C).
• When minor manifestations alone are present, the
exclusion of other more likely causes of the clinical
presentation is recommended before a diagnosis of an
ARF recurrence is made (Class I; Level of Evidence C).
25.
26. “Possible” Rheumatic Fever
• In some circumstances, a given clinical
presentation may not fulfill these updated Jones
criteria, but the clinician may still have good reason
to suspect that ARF is the diagnosis.
• This may occur in high-incidence settings where,
for example, laboratory tests for acute phase
reactants or for confirmation of recent
streptococcal infection are not available,
documentation of clinical features is not clear, or
the history is not considered to be reliable.
• In such situations, clinicians should use their
discretion and clinical acumen to make the
diagnosis that they consider most likely and
manage the patient accordingly.
27. • Where there is genuine uncertainty, it is
reasonable to consider offering 12 months of
secondary prophylaxis followed by reevaluation
to include a careful history and physical
examination in addition to a repeat
echocardiogram (Class IIa; Level of Evidence
C).
• In a patient with recurrent symptoms (particularly
involving the joints) who has been adherent to
prophylaxis recommendations but lacks
serological evidence of group A streptococcal
infection and lacks echocardiographic evidence
of valvulitis, it is reasonable to conclude that the
recurrent symptoms are not likely related to ARF,
28. Take Home Message
• Strict application of echocardiography/Doppler
findings may be used to fulfill the major criterion of
carditis, even in the absence of classic auscultatory
findings
• Monoarthritis or polyarthralgia could be accepted as
fulfilling the major criterion of arthritis, but only in
moderate- to high-risk populations
• The requirement for the presence of fever can be
fulfilled with oral, tympanic, or rectal temperature
documented at 38°C in moderate- to high-risk
populations