This document provides an overview of reconstruction techniques in head and neck surgery. It discusses Gillie's principles of reconstruction and the reconstructive ladder. It describes various techniques including skin grafts, local flaps such as nasolabial and forehead flaps, distant flaps such as deltopectoral and latissimus dorsi flaps, and free tissue transfers including radial forearm and fibula flaps. It discusses factors to consider for each technique such as blood supply, advantages, disadvantages and appropriate applications in head and neck reconstruction.
Head and neck cancer reconstruction is arguably the
most challenging area of reconstruction for the reconstructive
surgeon. A clear understanding of the principles of use of local flaps and a comprehensive understanding of the anatomy of these flaps provides the head and neck surgeon with a plethora of local and regional options for primary and secondary reconstruction.
This powerpoint describes the types of maxillectomy & operative steps for total maxillectomy. It also enumerates various flaps used for reconstruction of maxillectomy defect.
Micro vascular free flaps used in head and neck reconstruction /certified fi...Indian dental academy
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Head and neck cancer reconstruction is arguably the
most challenging area of reconstruction for the reconstructive
surgeon. A clear understanding of the principles of use of local flaps and a comprehensive understanding of the anatomy of these flaps provides the head and neck surgeon with a plethora of local and regional options for primary and secondary reconstruction.
This powerpoint describes the types of maxillectomy & operative steps for total maxillectomy. It also enumerates various flaps used for reconstruction of maxillectomy defect.
Micro vascular free flaps used in head and neck reconstruction /certified fi...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Flaps for reconstruction/periodontics courses by indian dental academyIndian dental academy
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Gillie’s principles of reconstructive
surgery
‘Losses must be replaced in kind’
‘Treat the primary defect’
‘Thou shalt provide thyself with a life boat’
‘Thou shalt not throw away a living thing’
‘Replace things in to their normal position by recreation of the defect’
4. Relaxed skin tension lines:
These lines are parallel to natural skin wrinkles and tend to be perpendicular to the underlying muscle
fibers.
Cosmetic subunits:
Ideally, individual subunits should be reconstructed separately and scars shouldn't cross the subunits
if possible.
5.
6.
7. Skin grafts
A skin graft is something that is potentially dead and its survival depends on how its treated.
Lifespan up to 3 weeks if wrapped and moistened with normal saline at 4 degrees
types:
Split thickness
Full thickness
Composite
Pinch
Fat and dermal
Chondro-mucosal
8. Graft take
1.Skin graft adherence
2.Serum imbibition
3.Revascularization
4.Remodeling
Factors affecting the take:
Most common cause of graft loss is haematoma or seroma
Streptococcus pyogenes, Pseudomonas aeruginosa and MRSA
Diabetes , smoking , previous radiotherapy and chemotherapy
9. Split thickness skin graft(STSGs)
Thickness depends upon the amount of dermis that is included with the epidermis
1. Thin
2. Intermediate
3. Thick
Graft taken with dermatome (0.3-0.4mm) or humby knife(0.3mm)
Under goes increased secondary contraction
Less robust , abnormal pigmentation and limited sensory recovery
Donor site heals by re-epithelization by hail follicles
10.
11.
12. Full thickness skin graft
Takes with it full thickness of dermis
Graft is taken with a scalpel
Donor site heals by secondary intention
It is bulky, contracts less and has increased chances of failure due to higher metabolic rate
Pigmentation is almost the same as the recipient
It is more robust and has a better sensory recovery
13. Bare bone or cartilage doesn't take graft
Crane principle is used for this purpose
Surfaces that take graft well are:
1.Granulation tissue
2.Soft tissues of face
3.Muscle fascia and fat cartilage
4.Bone covered with periosteum or perichondrium
14.
15.
16. Flaps
A flap is a graft that remains attached at one or more points to its pedicle which provides an
arterial blood supply with venous and lymphatic drainage.
Types
1.Local
2.Distant axial
3.Myocutaneous
4.Free flap
17. Local flaps
It is composed of tissue adjacent to the defect
Classification based on:
a.Blood supply:
1.Random flaps
2.Axial flaps
b.Method of movement
1.Advancement flap
2.Pivot flap
3.Interpolation flap
19. Random flaps
Based on rich subdermal vascular plexus of skin
Most of the local flaps are random flaps
length : breadth ratio of up to 3 : 1 in the face.
20. Axial flaps
Derive their blood supply from a direct cutaneous artery or named blood vessel.
Examples :Nasolabial flap (angular artery) ,Forehead flap(supratrochlear artery).
The surviving length of an axial pattern flap is entirely related to the length of the included
artery.
21.
22. Based on vascular pedicle types
In muscles
Type I: one vascular pedicle
Type II: dominant pedicle (s) + minor pedicles
Type III: two dominant pedicles
Type IV: Segmental vascular pedicles
Type V: dominant pedicle + secondary segmental pedicles
23.
24. Advancement flaps
Burrows Triangle’s: Flap moves in a straight path without any lateral movement into the primary
defect.
sites – forehead, brow, cheek.
V-Y adv. Flap: A V shaped flap is moved into a defect with primary closure of the donor area leaving
a final Y shaped suture line. It is pedicled from the underlying subcutaneous tissue rather than the
surrounding skin. Ideal for Lesion in the cheek and alar base.
Panthographic expansion: instead of the flap being advanced as a rectangle, the limbs of the flap are
designed at 120º with back cuts at the bottom so that it looks like an inverted tumbler. The flap is
then advanced so that the donor site closes primarily. This technique is particularly useful on the
cheek and neck.
25.
26.
27. Pivot Flaps
Derives its name from the pivot point at the base of the flap as well as its arc of rotation .
When flap moves laterally into the primary defect - transposition flap
when it is rotated into the defect - rotation flap
Rhomboid flaps: A flap where the donor defect is closed directly. The rhomboid has sides equal
in length and angles of 120 degree and 60 degree respectively. Scar should be parallel to the
relaxed skin tension line.
28. Pivot flaps cont.
Flag or banner flaps: glabellar flap.
Blobbed flap: The first flap is transposed in to the primary defect, the second flap is transposed
in to the secondary defect and the tertiary defect is closed primarily. Used to deal with defects
on the tip of nose.
Tripier flap
29.
30.
31.
32.
33. Interpolation flaps
An interpolation flap is from a nearby, but not immediately adjacent donor Site and transposed
either above or below the intervening skin to the Recipient defect.
Types:
Cutaneous: requires two stage procedure but more reliable
Subcutaneous Island
E.g.: Median forehead flap ,Nasolabial flap
34. Nasolabial flap
Reconstruction of facial skin defects of the upper lip, nose and cheek following extirpation of
skin cancers.
Superiorly based nasolabial flap- closure of the oro-antral fistulae.
The bilateral inferiorly based nasolabial flap has utility in the reconstruction of the anterior
defects of the floor of the mouth.
Defect in the anterior face, nose and upper lip, floor of the mouth, OAF
35.
36. Median forehead flap
The forehead flap is an axial flap used to reconstruct defects below the level of the eyes. The
most commonly raised forehead flap is the cutaneous axial median forehead flap, based on the
supratrochlear artery. It can be raised and transposed to reconstruct areas in the upper medial
cheek region and the lower half of the nose and alar rim
If a radial forearm flap fails in the mouth and an immediate, reliable 'lifeboat' is required; the
forehead flap may be quickly raised to get the surgeon out of trouble!
37.
38. Distant axial flaps
Deltopectoral flap:
Based on upper 3-4 branches of internal mammary artery
Boundaries:
a. superiorly: clavicle
b. Laterally: acromium
c. Inferiorly: a line drawn from the anteriorly axillary fold to just above the nipple.
39. Deltopectoral flap cont.
Retracts from side to side and not from end to end
Flexibility is due to anomalous pivot point
The pectoral fascia is left on the flap leaving the muscle fibers below absolutely bare.
Donor site is covered with a split skin graft
Uses:
1. To cover the whole anterior neck skin
2. To reconstruct a defect by passing as a bridge over a normal tissue
3. To reconstruct large defects on the lower face and upper neck
40.
41. Myocutaneous flaps
Essential surgical points:
a. Blood supply of the muscle is axial while that of the overlying skin is random
b. There is a minimum size of skin paddle to insure its survival
c. For pec major and lat dorsi flap its 5x3 cm( the size of the palm of an adult hand)
42. Pectoralis major flap
Pec major has a type V blood supply
Flap is based on the pectoral branch of acromiothoracic artery which arises from the first part of
axillary artery.
Highly reliable even if the skin paddle fails the underlying muscle will usually survive and can be
allowed to granulate and heal by secondary intention, or covered subsequently with a skin graft.
With the pt in supine position the surface markings of the acromiothoracic artery are outlined.
A dotted line is marked from the acromium to the xiphoid process and a further dotted line is
dropped to join this line in a perpendicular direction from sternal notch.
43. The point at which line bisects the first line represents the place where the vascular pedicle
meets the first line which then runs in the direction of the first line from the acromium towards
the xiphisternum.
Advantages and uses:
1. Large skin territory
2. Rich vascular supply
3. Large arc of rotation
4. Can be harvested in supine position
44. 5. Can be transferred as muscle only , skin and muscle paddle or as 2 epithelial surfaces for inner
and outer lining with the de-epitheliazed segment b/w them.
6. Primary donor site closure is easily achievable
7. Usually used to fill large defects where mobility is not of paramount
as in the repair of fistulae.
Disadvantages:
1. Bulky
2. Virtually impossible to tube it
45. 3. Cannot be used in females as it violates the breast.
4. Retracts by 10% in all directions
Congenital absence of pec major 1: 11000
Congenital absence of sternocostal head occurs in Poland syndrome.
46.
47. Latissimus dorsi flap
Based on thoracodorsal artery
Flaps measuring 10x8 cm are easily harvested with primary closure of donor site.
Can be used as both myocutaneous or free flap, its long pedicle(10cm) is reliable and can be
lengthened by dividing the circumflex scapular artery.
It is used in filling of larger holes in head and neck and for the repair of nasopharyngeal fistulae
rather than use within the oral cavity, unless required to repair defects following total
glossectomy
48. Advanatages:
1. Large amounts of tissue transferred
2. Pedicled or free tissue transfer
3. Cosmetic advantage especialy females
4. versatile: may be tubed/multiple/osseous components
5. When pedicled can reach the upper face and scalp
49. Disadvantages:
1. Very bulky
2. Occasional donor site dehiscence
3. Reduction in upper limb power
4. Need to move the patient to harvest
52. Free tissue transfer
Radial free forearm flap:
Based on radial artery
It is one of the workhorses for head and neck reconstruction, providing pliable skin which may
be used to reconstruct three dimensional defects, particularly within the oral cavity. It can
provide skin and fascia and if required, vascularized tendon, nerve and bone may be combined
in the flap. It may be use as a fascial flap for recontouring.
Allen’s and Doppler angiography is done pre-op to check the patency of ulnar artery.
53. The radial artery sits in the condensation of the intermuscular septum in a trench in between
brachioradialis and flexor carpi ulnaris and flap elevation must allow the artery to be raised with
the septum.
Upto 10cm of bone can be taken with the flap between pronator teres and pronator quadratus
The thickness of the bone that can be taken with safety is less than half the cross section of
radius.
54. Advantages:
1.Suited for 3 dimensional intraoral reconstruction
2. Provides a sensate flap via 2 cutaneous forearm nerves
3. Preoperative assessment is possible
4. Easy to raise
5. Reliable
6. Thin , pliable skin
7. Long pedicle
8.Good sized vessels
9. versatile
57. Fibula flap
Based on peroneal artery
Upto 20-25cm of bone can be harvested
The skin paddle is a fasciocutaneous flap centered on the peroneal intermuscular septum and
therefore the deep fascia must always be included when the flap is raised.
The segment of bone to be used is based on the midportion of fibula
The pedicle is short , and for head and neck reconstruction it may be necessary to take a
saphenous vein graft and perform an A-V fistula in the neck i.e. joining the ECA or 1 of its
branches to the IJV with the graft and allowing this to function.
58. Uses:
Provides good cortical bone which is reliable
Ideally suited for angle to angle mandibular defects
Also useful for maxillary reconstruction
Major disadvantage is that the skin paddle is unreliable.
59.
60.
61. Occasionally used free flaps in head and neck:
Pec minor flap
Temporoparietal flap
Groin flap
Gracilis flap
Serratus anterior flap
Omentum flap