SlideShare a Scribd company logo
RADIOPHARMACEUTICALS
PREPARED BY:AKSHITA
B.PHARMACY-1
1503
RADIOACTIVITY
 It refers to the radiations or particles which are emitted from
nuclei as a result of nuclear instability.
 These radiations are generally emitted from heavy metals like:
uranium , thorium , radium , etc.
 The substances that emits such radiations are called
RADIOACTIVE SUBSTANCE.
 The phenomenol of spontaneous and continuous emition of
such radiations is called RADIOACTIVITY.
PROPERTIES OF
RADIOACTIVITY
 These radiations can penetrate through solid material , can ionize
the gases , produce a glow on zinc sulphide[ZnSO4] paint or affect
the photographic plates.
 These radiations are emitted without any external agencies.
 These are independent of temperature , pressure ,
concentration , or catalyst.
TYPES OF RADIATIONS
 The radiations emitted by the radioactive isotopes is in the
form of charged particles i.e. ALPHA RAYS AND BETA
RAYS[alpha is positively charged and beta is negatively
charged]
 There are some uncharged particles also that are called
GAMMA RAYS .
MEASUREMENT OF
RADIOACTIVITY
 To measure the radiations of alpha beta and gamma rays
many techniques involving DETECTION and COUNTING
OF INDIVIDUAL PARTICLES , PHOTONS have been
available.
 The method selected for the measurement of radioactivity
depends upon the “extent of energy dissipation and
penetrability of radiation.”
MEASUREMENT OF
RADIOACTIVITY
 For measurement of radioactivity many devices are used. Some are
listed below:
 IONIZATION CHAMBER
 PROPORTIONAL CHAMBER
 SCINTILLATION COUNTER
 GEIGER-MULLER COUNTER
 SEMICONDUCTOR DETECTORS
 PHOTOGRAPHIC PLATE METHOD
IONIZATION CHAMBER
IONIZATION CHAMBER
 These are of various shapes and sizes.
 A chamber is filled with GAS and is fitted with TWO
ELECTRODES kept a different potentials .
 It is connected to a measuring device to indicate the FLOW OF
ELECTRIC CURRENT.
 The filled gas can be He , Ar , etc.
 They have poor resolution due to large number of chrge carriers.
PRINCIPLE:
 The radiation causes ionization of gas molecules or produce
ions which result in the emission of electrons.
 This shows change in electric current which is measured
with measuring device.
 The current produced is of 10-15 ampere.
PROPORTIONAL
COUNTER
PROPORTIONAL
COUNTER
 The proportional counter is a type of gaseous ionization detector
device used to measure particles of ionizing radiation.
 The key feature is its ability to measure the energy of incident
radiation, by producing a detector output that is proportional to the
radiation energy; hence the detector's name.
SCINTILLATION
COUNTER
SCINTILLATION
COUNTER
 A scintillation counter is an instrument for detecting and
measuring ionizing radiation by using the excitation effect of
incident radiation on a scintillator material, and detecting the
resultant light pulses.
 The counter consists of a scintillation crystal coupled with
PHOTOMULTIPLIER TUBE , an AMPLIFIER and a SCALER.
PRINCIPLE
 When ionizing radiation strikes certain substances like
phosphorous [or a flurogenic materials] a flash of light is given
out .
 The flash is collected by a photomultiplier tube which
produces electric impulse.
 This impulse , on further amplification , is recorded by
means of a scaler.
TWO MAIN TYPES:
 INORGANIC SCINTILLATOR[ SODIUM IODIDE]:
This is for gamma rays.
 ORGANIC SCINTILLATOR
This is for alpha and beta rays.
GEIGER COUNTERS
 The Geiger counter is an instrument used for
measuring ionizing radiation used widely in applications such
as radiation dosimetry , radiological protection, experimental
physics and the nuclear industry.
 This is commomly known as GEIGER MULLER[GM] and is
the best of all radiation detectors.
 They can detect all the three types of radiations [ alpha , beta
and gamma]
CONSTRUCTION
 A Geiger counter consists of a
Geiger-Müller tube, the sensing
element which detects the radiation
and the processing electronics
which displays the result.
PRINCIPLE
 The Geiger-Müller tube is filled with an inert gas such as helium, neon,
or argon at low pressure, to which a high voltage is applied. The tube briefly
conducts electrical charge when a particle or photon of incident radiation makes
the gas conductive by ionization. The ionization is considerably amplified within
the tube by the Townsend discharge effect to produce an easily measured
detection pulse, which is fed to the processing and display electronics. This large
pulse from the tube makes the G-M counter relatively cheap to manufacture, as
the subsequent electronics is greatly simplified.[2] The electronics also generates
the high voltage, typically 400–600 volts, that has to be applied to the Geiger-
Müller tube to enable its operation.
SEMICONDUCTOR
DETECTOR
 They are useful in measuring X-rays and Gamma rays.
 In this, charge carriers produced by ionizing radiation are
electron-hole pairs.
 These travel towards the positive electrodes with high
velocities.
PHOTOGRAPHIC PLATE
METHOD
 An ionizing particle causes an activation and darkening of a
photographic plate.
 The degree of darkening gives the measure of the total
activity.
 This method is used to locate the exact distribution of
radioactive material in a thin section.
 This method is mainly detect the GAMMA Rays.

More Related Content

What's hot

Scintillation Detector.pptx
Scintillation Detector.pptxScintillation Detector.pptx
Scintillation Detector.pptx
MandeepKaur528541
 
Half life of radioactive material
Half life of radioactive materialHalf life of radioactive material
Half life of radioactive material
MirzaMusmanBaig
 
Gas filled detectors
Gas filled detectorsGas filled detectors
Gas filled detectors
Amara Usman
 
Presentation for Radioactivity
Presentation for RadioactivityPresentation for Radioactivity
Presentation for RadioactivityHira Rizvi
 
Radioactive decay
Radioactive decayRadioactive decay
Radioactive decay
Sarbjit Rindi
 
Nuclear Medicine Instrumentation and quality control presentation
 Nuclear Medicine Instrumentation and quality control presentation Nuclear Medicine Instrumentation and quality control presentation
Nuclear Medicine Instrumentation and quality control presentation
Mumba Chilimboyi
 
Radioactivity and laws of radioactivity
Radioactivity and laws of radioactivityRadioactivity and laws of radioactivity
Radioactivity and laws of radioactivity
dypradio
 
Production of x rays
Production of x rays Production of x rays
Production of x rays
VIneeth C
 
Radiation safety in diagnostic nuclear medicine
Radiation safety in diagnostic nuclear medicineRadiation safety in diagnostic nuclear medicine
Radiation safety in diagnostic nuclear medicine
SGPGIMS
 
Interaction of ionising radiation
Interaction of ionising radiationInteraction of ionising radiation
Interaction of ionising radiation
Kiran Ramakrishna
 
Lecture 1 basic nuclear physics 1 - basic atomic structure
Lecture 1   basic nuclear physics 1 - basic atomic structureLecture 1   basic nuclear physics 1 - basic atomic structure
Lecture 1 basic nuclear physics 1 - basic atomic structure
Delovita ginting
 
Chapter 22.2 : Radioactive Decay
Chapter 22.2 : Radioactive DecayChapter 22.2 : Radioactive Decay
Chapter 22.2 : Radioactive DecayChris Foltz
 
Background Radiation
Background RadiationBackground Radiation
Background Radiation
Iqlaas Sherif
 
X ray tube
X ray tubeX ray tube
X ray tubeRad Tech
 
Chapter 3 detection devices
Chapter 3 detection devicesChapter 3 detection devices
Chapter 3 detection devicesROBERT ESHUN
 
Radiation detectors
Radiation detectors Radiation detectors
Radiation detectors
Jonathan Lalrinmawia
 
Radiation detection and measurement
Radiation detection and measurement Radiation detection and measurement
Radiation detection and measurement Shahid Younas
 
Radioactivity.pptx
Radioactivity.pptxRadioactivity.pptx
Radioactivity.pptx
Rachana Choudhary
 
Nuclear medicine
Nuclear medicineNuclear medicine
Nuclear medicine
Shrikant Nagare
 

What's hot (20)

Scintillation Detector.pptx
Scintillation Detector.pptxScintillation Detector.pptx
Scintillation Detector.pptx
 
Half life of radioactive material
Half life of radioactive materialHalf life of radioactive material
Half life of radioactive material
 
Gas filled detectors
Gas filled detectorsGas filled detectors
Gas filled detectors
 
Presentation for Radioactivity
Presentation for RadioactivityPresentation for Radioactivity
Presentation for Radioactivity
 
Radioactive decay
Radioactive decayRadioactive decay
Radioactive decay
 
Nuclear Medicine Instrumentation and quality control presentation
 Nuclear Medicine Instrumentation and quality control presentation Nuclear Medicine Instrumentation and quality control presentation
Nuclear Medicine Instrumentation and quality control presentation
 
Radioactivity and laws of radioactivity
Radioactivity and laws of radioactivityRadioactivity and laws of radioactivity
Radioactivity and laws of radioactivity
 
Production of x rays
Production of x rays Production of x rays
Production of x rays
 
Radiation safety in diagnostic nuclear medicine
Radiation safety in diagnostic nuclear medicineRadiation safety in diagnostic nuclear medicine
Radiation safety in diagnostic nuclear medicine
 
Interaction of ionising radiation
Interaction of ionising radiationInteraction of ionising radiation
Interaction of ionising radiation
 
Lecture 1 basic nuclear physics 1 - basic atomic structure
Lecture 1   basic nuclear physics 1 - basic atomic structureLecture 1   basic nuclear physics 1 - basic atomic structure
Lecture 1 basic nuclear physics 1 - basic atomic structure
 
Chapter 22.2 : Radioactive Decay
Chapter 22.2 : Radioactive DecayChapter 22.2 : Radioactive Decay
Chapter 22.2 : Radioactive Decay
 
Background Radiation
Background RadiationBackground Radiation
Background Radiation
 
X ray tube
X ray tubeX ray tube
X ray tube
 
Chapter 3 detection devices
Chapter 3 detection devicesChapter 3 detection devices
Chapter 3 detection devices
 
Radiation detectors
Radiation detectors Radiation detectors
Radiation detectors
 
Radioactivity
RadioactivityRadioactivity
Radioactivity
 
Radiation detection and measurement
Radiation detection and measurement Radiation detection and measurement
Radiation detection and measurement
 
Radioactivity.pptx
Radioactivity.pptxRadioactivity.pptx
Radioactivity.pptx
 
Nuclear medicine
Nuclear medicineNuclear medicine
Nuclear medicine
 

Similar to Radiopharmaceuticals final

Nuclear i nstrumentation
Nuclear i nstrumentationNuclear i nstrumentation
Nuclear i nstrumentation
shalet kochumuttath Shaji
 
Slide share
Slide share Slide share
Slide share
Vasuki Arumugam
 
Radiation detection and measurements
Radiation detection and measurementsRadiation detection and measurements
Radiation detection and measurements
Vasuki Arumugam
 
Radiopharmaceuticals.pptx
Radiopharmaceuticals.pptxRadiopharmaceuticals.pptx
Radiopharmaceuticals.pptx
MihirDeshmukh7
 
Pharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptx
Pharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptxPharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptx
Pharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptx
Ms. Pooja Bhandare
 
Nuclear radiation detecters
Nuclear radiation detectersNuclear radiation detecters
Nuclear radiation detecters
SangeethaSivakumar10
 
Geiger muller counter
Geiger muller counter Geiger muller counter
Geiger muller counter
ARCHITBHARTI
 
Radiopharmaceuticals
RadiopharmaceuticalsRadiopharmaceuticals
Radiopharmaceuticals
muskaangandhi1
 
Radiopharmaceuticals 2
Radiopharmaceuticals 2Radiopharmaceuticals 2
Radiopharmaceuticals 2
Dipali Kulkarni
 
Radiation Detectors-operation and applications.pptx
Radiation Detectors-operation and applications.pptxRadiation Detectors-operation and applications.pptx
Radiation Detectors-operation and applications.pptx
debeshidutta2
 
Radiation detectors
Radiation detectorsRadiation detectors
Radiation detectors
Kiran Ramakrishna
 
Gm counter& scintillation counter
Gm counter& scintillation counterGm counter& scintillation counter
Gm counter& scintillation counter
SoniyaS13
 
Radioisotope technique and methods
Radioisotope technique and methodsRadioisotope technique and methods
Radioisotope technique and methods
University of Mumbai
 
radioisotopetechnique-161107054511.pdf
radioisotopetechnique-161107054511.pdfradioisotopetechnique-161107054511.pdf
radioisotopetechnique-161107054511.pdf
SrimathideviJ
 
nuclear radiation detector unit V
nuclear radiation detector unit Vnuclear radiation detector unit V
nuclear radiation detector unit V
Dr. Vishal Jain
 
Radioactivity and detection of radioactivity.pptx
Radioactivity and detection of radioactivity.pptxRadioactivity and detection of radioactivity.pptx
Radioactivity and detection of radioactivity.pptx
LalitKishore18
 
Radio-active Counters
Radio-active CountersRadio-active Counters
Radio-active Counters
Nizam Ashraf
 
Geiger muller counter- brief introduction
Geiger muller counter- brief introductionGeiger muller counter- brief introduction
Geiger muller counter- brief introduction
subhananthini jeyamurugan
 
Assignment radiation
Assignment radiationAssignment radiation
Assignment radiationSany Ali
 
Gamma ray spectroscopy
Gamma ray spectroscopyGamma ray spectroscopy
Gamma ray spectroscopy
AryaReson
 

Similar to Radiopharmaceuticals final (20)

Nuclear i nstrumentation
Nuclear i nstrumentationNuclear i nstrumentation
Nuclear i nstrumentation
 
Slide share
Slide share Slide share
Slide share
 
Radiation detection and measurements
Radiation detection and measurementsRadiation detection and measurements
Radiation detection and measurements
 
Radiopharmaceuticals.pptx
Radiopharmaceuticals.pptxRadiopharmaceuticals.pptx
Radiopharmaceuticals.pptx
 
Pharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptx
Pharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptxPharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptx
Pharmaceutical Inorganic chemistry UNIT-V Radiopharmaceutical.pptx
 
Nuclear radiation detecters
Nuclear radiation detectersNuclear radiation detecters
Nuclear radiation detecters
 
Geiger muller counter
Geiger muller counter Geiger muller counter
Geiger muller counter
 
Radiopharmaceuticals
RadiopharmaceuticalsRadiopharmaceuticals
Radiopharmaceuticals
 
Radiopharmaceuticals 2
Radiopharmaceuticals 2Radiopharmaceuticals 2
Radiopharmaceuticals 2
 
Radiation Detectors-operation and applications.pptx
Radiation Detectors-operation and applications.pptxRadiation Detectors-operation and applications.pptx
Radiation Detectors-operation and applications.pptx
 
Radiation detectors
Radiation detectorsRadiation detectors
Radiation detectors
 
Gm counter& scintillation counter
Gm counter& scintillation counterGm counter& scintillation counter
Gm counter& scintillation counter
 
Radioisotope technique and methods
Radioisotope technique and methodsRadioisotope technique and methods
Radioisotope technique and methods
 
radioisotopetechnique-161107054511.pdf
radioisotopetechnique-161107054511.pdfradioisotopetechnique-161107054511.pdf
radioisotopetechnique-161107054511.pdf
 
nuclear radiation detector unit V
nuclear radiation detector unit Vnuclear radiation detector unit V
nuclear radiation detector unit V
 
Radioactivity and detection of radioactivity.pptx
Radioactivity and detection of radioactivity.pptxRadioactivity and detection of radioactivity.pptx
Radioactivity and detection of radioactivity.pptx
 
Radio-active Counters
Radio-active CountersRadio-active Counters
Radio-active Counters
 
Geiger muller counter- brief introduction
Geiger muller counter- brief introductionGeiger muller counter- brief introduction
Geiger muller counter- brief introduction
 
Assignment radiation
Assignment radiationAssignment radiation
Assignment radiation
 
Gamma ray spectroscopy
Gamma ray spectroscopyGamma ray spectroscopy
Gamma ray spectroscopy
 

Recently uploaded

FAIR & AI Ready KGs for Explainable Predictions
FAIR & AI Ready KGs for Explainable PredictionsFAIR & AI Ready KGs for Explainable Predictions
FAIR & AI Ready KGs for Explainable Predictions
Michel Dumontier
 
platelets- lifespan -Clot retraction-disorders.pptx
platelets- lifespan -Clot retraction-disorders.pptxplatelets- lifespan -Clot retraction-disorders.pptx
platelets- lifespan -Clot retraction-disorders.pptx
muralinath2
 
Mammalian Pineal Body Structure and Also Functions
Mammalian Pineal Body Structure and Also FunctionsMammalian Pineal Body Structure and Also Functions
Mammalian Pineal Body Structure and Also Functions
YOGESH DOGRA
 
erythropoiesis-I_mechanism& clinical significance.pptx
erythropoiesis-I_mechanism& clinical significance.pptxerythropoiesis-I_mechanism& clinical significance.pptx
erythropoiesis-I_mechanism& clinical significance.pptx
muralinath2
 
Citrus Greening Disease and its Management
Citrus Greening Disease and its ManagementCitrus Greening Disease and its Management
Citrus Greening Disease and its Management
subedisuryaofficial
 
GBSN - Biochemistry (Unit 5) Chemistry of Lipids
GBSN - Biochemistry (Unit 5) Chemistry of LipidsGBSN - Biochemistry (Unit 5) Chemistry of Lipids
GBSN - Biochemistry (Unit 5) Chemistry of Lipids
Areesha Ahmad
 
Anemia_ different types_causes_ conditions
Anemia_ different types_causes_ conditionsAnemia_ different types_causes_ conditions
Anemia_ different types_causes_ conditions
muralinath2
 
filosofia boliviana introducción jsjdjd.pptx
filosofia boliviana introducción jsjdjd.pptxfilosofia boliviana introducción jsjdjd.pptx
filosofia boliviana introducción jsjdjd.pptx
IvanMallco1
 
platelets_clotting_biogenesis.clot retractionpptx
platelets_clotting_biogenesis.clot retractionpptxplatelets_clotting_biogenesis.clot retractionpptx
platelets_clotting_biogenesis.clot retractionpptx
muralinath2
 
Richard's aventures in two entangled wonderlands
Richard's aventures in two entangled wonderlandsRichard's aventures in two entangled wonderlands
Richard's aventures in two entangled wonderlands
Richard Gill
 
Lateral Ventricles.pdf very easy good diagrams comprehensive
Lateral Ventricles.pdf very easy good diagrams comprehensiveLateral Ventricles.pdf very easy good diagrams comprehensive
Lateral Ventricles.pdf very easy good diagrams comprehensive
silvermistyshot
 
insect taxonomy importance systematics and classification
insect taxonomy importance systematics and classificationinsect taxonomy importance systematics and classification
insect taxonomy importance systematics and classification
anitaento25
 
Penicillin...........................pptx
Penicillin...........................pptxPenicillin...........................pptx
Penicillin...........................pptx
Cherry
 
Orion Air Quality Monitoring Systems - CWS
Orion Air Quality Monitoring Systems - CWSOrion Air Quality Monitoring Systems - CWS
Orion Air Quality Monitoring Systems - CWS
Columbia Weather Systems
 
In silico drugs analogue design: novobiocin analogues.pptx
In silico drugs analogue design: novobiocin analogues.pptxIn silico drugs analogue design: novobiocin analogues.pptx
In silico drugs analogue design: novobiocin analogues.pptx
AlaminAfendy1
 
ESR_factors_affect-clinic significance-Pathysiology.pptx
ESR_factors_affect-clinic significance-Pathysiology.pptxESR_factors_affect-clinic significance-Pathysiology.pptx
ESR_factors_affect-clinic significance-Pathysiology.pptx
muralinath2
 
Viksit bharat till 2047 India@2047.pptx
Viksit bharat till 2047  India@2047.pptxViksit bharat till 2047  India@2047.pptx
Viksit bharat till 2047 India@2047.pptx
rakeshsharma20142015
 
Hemostasis_importance& clinical significance.pptx
Hemostasis_importance& clinical significance.pptxHemostasis_importance& clinical significance.pptx
Hemostasis_importance& clinical significance.pptx
muralinath2
 
general properties of oerganologametal.ppt
general properties of oerganologametal.pptgeneral properties of oerganologametal.ppt
general properties of oerganologametal.ppt
IqrimaNabilatulhusni
 
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...
Sérgio Sacani
 

Recently uploaded (20)

FAIR & AI Ready KGs for Explainable Predictions
FAIR & AI Ready KGs for Explainable PredictionsFAIR & AI Ready KGs for Explainable Predictions
FAIR & AI Ready KGs for Explainable Predictions
 
platelets- lifespan -Clot retraction-disorders.pptx
platelets- lifespan -Clot retraction-disorders.pptxplatelets- lifespan -Clot retraction-disorders.pptx
platelets- lifespan -Clot retraction-disorders.pptx
 
Mammalian Pineal Body Structure and Also Functions
Mammalian Pineal Body Structure and Also FunctionsMammalian Pineal Body Structure and Also Functions
Mammalian Pineal Body Structure and Also Functions
 
erythropoiesis-I_mechanism& clinical significance.pptx
erythropoiesis-I_mechanism& clinical significance.pptxerythropoiesis-I_mechanism& clinical significance.pptx
erythropoiesis-I_mechanism& clinical significance.pptx
 
Citrus Greening Disease and its Management
Citrus Greening Disease and its ManagementCitrus Greening Disease and its Management
Citrus Greening Disease and its Management
 
GBSN - Biochemistry (Unit 5) Chemistry of Lipids
GBSN - Biochemistry (Unit 5) Chemistry of LipidsGBSN - Biochemistry (Unit 5) Chemistry of Lipids
GBSN - Biochemistry (Unit 5) Chemistry of Lipids
 
Anemia_ different types_causes_ conditions
Anemia_ different types_causes_ conditionsAnemia_ different types_causes_ conditions
Anemia_ different types_causes_ conditions
 
filosofia boliviana introducción jsjdjd.pptx
filosofia boliviana introducción jsjdjd.pptxfilosofia boliviana introducción jsjdjd.pptx
filosofia boliviana introducción jsjdjd.pptx
 
platelets_clotting_biogenesis.clot retractionpptx
platelets_clotting_biogenesis.clot retractionpptxplatelets_clotting_biogenesis.clot retractionpptx
platelets_clotting_biogenesis.clot retractionpptx
 
Richard's aventures in two entangled wonderlands
Richard's aventures in two entangled wonderlandsRichard's aventures in two entangled wonderlands
Richard's aventures in two entangled wonderlands
 
Lateral Ventricles.pdf very easy good diagrams comprehensive
Lateral Ventricles.pdf very easy good diagrams comprehensiveLateral Ventricles.pdf very easy good diagrams comprehensive
Lateral Ventricles.pdf very easy good diagrams comprehensive
 
insect taxonomy importance systematics and classification
insect taxonomy importance systematics and classificationinsect taxonomy importance systematics and classification
insect taxonomy importance systematics and classification
 
Penicillin...........................pptx
Penicillin...........................pptxPenicillin...........................pptx
Penicillin...........................pptx
 
Orion Air Quality Monitoring Systems - CWS
Orion Air Quality Monitoring Systems - CWSOrion Air Quality Monitoring Systems - CWS
Orion Air Quality Monitoring Systems - CWS
 
In silico drugs analogue design: novobiocin analogues.pptx
In silico drugs analogue design: novobiocin analogues.pptxIn silico drugs analogue design: novobiocin analogues.pptx
In silico drugs analogue design: novobiocin analogues.pptx
 
ESR_factors_affect-clinic significance-Pathysiology.pptx
ESR_factors_affect-clinic significance-Pathysiology.pptxESR_factors_affect-clinic significance-Pathysiology.pptx
ESR_factors_affect-clinic significance-Pathysiology.pptx
 
Viksit bharat till 2047 India@2047.pptx
Viksit bharat till 2047  India@2047.pptxViksit bharat till 2047  India@2047.pptx
Viksit bharat till 2047 India@2047.pptx
 
Hemostasis_importance& clinical significance.pptx
Hemostasis_importance& clinical significance.pptxHemostasis_importance& clinical significance.pptx
Hemostasis_importance& clinical significance.pptx
 
general properties of oerganologametal.ppt
general properties of oerganologametal.pptgeneral properties of oerganologametal.ppt
general properties of oerganologametal.ppt
 
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...
 

Radiopharmaceuticals final

  • 2.
  • 3. RADIOACTIVITY  It refers to the radiations or particles which are emitted from nuclei as a result of nuclear instability.  These radiations are generally emitted from heavy metals like: uranium , thorium , radium , etc.  The substances that emits such radiations are called RADIOACTIVE SUBSTANCE.  The phenomenol of spontaneous and continuous emition of such radiations is called RADIOACTIVITY.
  • 4. PROPERTIES OF RADIOACTIVITY  These radiations can penetrate through solid material , can ionize the gases , produce a glow on zinc sulphide[ZnSO4] paint or affect the photographic plates.  These radiations are emitted without any external agencies.  These are independent of temperature , pressure , concentration , or catalyst.
  • 5. TYPES OF RADIATIONS  The radiations emitted by the radioactive isotopes is in the form of charged particles i.e. ALPHA RAYS AND BETA RAYS[alpha is positively charged and beta is negatively charged]  There are some uncharged particles also that are called GAMMA RAYS .
  • 6. MEASUREMENT OF RADIOACTIVITY  To measure the radiations of alpha beta and gamma rays many techniques involving DETECTION and COUNTING OF INDIVIDUAL PARTICLES , PHOTONS have been available.  The method selected for the measurement of radioactivity depends upon the “extent of energy dissipation and penetrability of radiation.”
  • 7. MEASUREMENT OF RADIOACTIVITY  For measurement of radioactivity many devices are used. Some are listed below:  IONIZATION CHAMBER  PROPORTIONAL CHAMBER  SCINTILLATION COUNTER  GEIGER-MULLER COUNTER  SEMICONDUCTOR DETECTORS  PHOTOGRAPHIC PLATE METHOD
  • 9. IONIZATION CHAMBER  These are of various shapes and sizes.  A chamber is filled with GAS and is fitted with TWO ELECTRODES kept a different potentials .  It is connected to a measuring device to indicate the FLOW OF ELECTRIC CURRENT.  The filled gas can be He , Ar , etc.  They have poor resolution due to large number of chrge carriers.
  • 10. PRINCIPLE:  The radiation causes ionization of gas molecules or produce ions which result in the emission of electrons.  This shows change in electric current which is measured with measuring device.  The current produced is of 10-15 ampere.
  • 12. PROPORTIONAL COUNTER  The proportional counter is a type of gaseous ionization detector device used to measure particles of ionizing radiation.  The key feature is its ability to measure the energy of incident radiation, by producing a detector output that is proportional to the radiation energy; hence the detector's name.
  • 14. SCINTILLATION COUNTER  A scintillation counter is an instrument for detecting and measuring ionizing radiation by using the excitation effect of incident radiation on a scintillator material, and detecting the resultant light pulses.  The counter consists of a scintillation crystal coupled with PHOTOMULTIPLIER TUBE , an AMPLIFIER and a SCALER.
  • 15. PRINCIPLE  When ionizing radiation strikes certain substances like phosphorous [or a flurogenic materials] a flash of light is given out .  The flash is collected by a photomultiplier tube which produces electric impulse.  This impulse , on further amplification , is recorded by means of a scaler.
  • 16. TWO MAIN TYPES:  INORGANIC SCINTILLATOR[ SODIUM IODIDE]: This is for gamma rays.  ORGANIC SCINTILLATOR This is for alpha and beta rays.
  • 17. GEIGER COUNTERS  The Geiger counter is an instrument used for measuring ionizing radiation used widely in applications such as radiation dosimetry , radiological protection, experimental physics and the nuclear industry.  This is commomly known as GEIGER MULLER[GM] and is the best of all radiation detectors.  They can detect all the three types of radiations [ alpha , beta and gamma]
  • 18. CONSTRUCTION  A Geiger counter consists of a Geiger-Müller tube, the sensing element which detects the radiation and the processing electronics which displays the result.
  • 19. PRINCIPLE  The Geiger-Müller tube is filled with an inert gas such as helium, neon, or argon at low pressure, to which a high voltage is applied. The tube briefly conducts electrical charge when a particle or photon of incident radiation makes the gas conductive by ionization. The ionization is considerably amplified within the tube by the Townsend discharge effect to produce an easily measured detection pulse, which is fed to the processing and display electronics. This large pulse from the tube makes the G-M counter relatively cheap to manufacture, as the subsequent electronics is greatly simplified.[2] The electronics also generates the high voltage, typically 400–600 volts, that has to be applied to the Geiger- Müller tube to enable its operation.
  • 20. SEMICONDUCTOR DETECTOR  They are useful in measuring X-rays and Gamma rays.  In this, charge carriers produced by ionizing radiation are electron-hole pairs.  These travel towards the positive electrodes with high velocities.
  • 21. PHOTOGRAPHIC PLATE METHOD  An ionizing particle causes an activation and darkening of a photographic plate.  The degree of darkening gives the measure of the total activity.  This method is used to locate the exact distribution of radioactive material in a thin section.  This method is mainly detect the GAMMA Rays.