A 41-year-old woman presented with hand pain. Radiographs of her hands showed a lacelike appearance of the bones with small lytic lesions affecting the small bones, particularly the middle and distal phalanges. These lesions typically have a lytic or lacy reticular appearance and represent an osteoporotic tunneling process producing destructive lesions involving the bone cortex and medulla. Accompanying soft tissue swelling is also often seen. This presentation is characteristic of sarcoidosis affecting the small bones of the hands.