This document discusses radial, median, and ulnar nerve injuries. It describes the anatomy and course of each nerve, typical injury locations and mechanisms, clinical features of injuries, and classifications of nerve injuries. Treatment options are also summarized, including nerve mobilization, grafting, and surgical techniques like neurolysis and neurorrhaphy.
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
Claw Hand,Definition,Causes,Types,Symptoms and ManagementDr.Md.Monsur Rahman
Dr.Md.Monsur Rahman, Bachelor of Physiotherapy (BPT), Master of Physiotherapy (MPT) in Musculoskeletal Disorders, ABC-Spine in Osteopathic Approach,
Maharishi Markandeshwar (Deemed to be University), Ambala -Haryana.
anatomy of median nerve,course in arm and struthers ligament, branches in the forearm, carpal tunnel and course in hand, high and low median nerve injuries, principles of surgical management, pronator teres syndrome, anterior interosseous nerve syndrome, open and endoscopic carpal tunnel release
Claw Hand,Definition,Causes,Types,Symptoms and ManagementDr.Md.Monsur Rahman
Dr.Md.Monsur Rahman, Bachelor of Physiotherapy (BPT), Master of Physiotherapy (MPT) in Musculoskeletal Disorders, ABC-Spine in Osteopathic Approach,
Maharishi Markandeshwar (Deemed to be University), Ambala -Haryana.
anatomy of median nerve,course in arm and struthers ligament, branches in the forearm, carpal tunnel and course in hand, high and low median nerve injuries, principles of surgical management, pronator teres syndrome, anterior interosseous nerve syndrome, open and endoscopic carpal tunnel release
The radial nerve is a continuation of posterior cord of brachial plexus in the axilla. It is the largest nerve of the brachial plexus. It supplies the posterior ( extensor) compartment of upper limb. It carries fibers from all the roots of ( C5,C6,C7,C8 and T1) of the brachial plexus. Allows you to move muscles and feel skin sensation in certain parts of the upper limb. Symptoms of radial nerve injury may include pain, numbness, and/or paresthasia especially in the middles finger, index finger , thumb , back of the hand and /or arm.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
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Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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3. Radial nerve
• C5,C6, C7, C8, T1
• It is the terminal branch of the posterior cord
of the brachial plexus
4. Course
oIn the axilla
• It lies anterior to the
subscapularis, teres major
and lattismus dorsi
muscle
• Motor supply to the long
head of triceps
• Posterior cutaneous nerve
of arm
5. In the arm
• Lies in the spiral groove of humerus
• Re-enters anterior compartment by
piercing lateral intermuscular
septum
• Motor supply to triceps (medial
and lateral head), anconeus,
brachialis, brachioradialis, extensor
carpi radialis longus
• Sensory : lower lateral cutaneous
nerve of arm
posterior cutaneous nerve
of forearm
6. In the elbow
• Anterior to the lateral
epicondyle, radial nerve
divides into the terminal
branches :
1. Posterior interosseus
nerve
2. Superficial radial sensory
nerve
7. In the forearm
• PIN reaches the back of the forearm
by passing round lateral aspect of the
radius between the two heads of
supinator
• As it emerges from the supinator
posteriorly, the nerve at first lies
between the superficial and deep
extensor muscles.
• At the distal border of extensor
pollicis brevis, it passes deep to
extensor pollicis longus and
diminished to a fine thread, descends
on the interosseus membrane to the
dorsum of the carpus- supply carpal
ligaments and articulations
10. Radial nerve injury
1. Very high– above the spiral
groove
• crutch palsy
• Saturday night palsy
• Trauma/operations around the
shoulder
2. High – at or below the spiral
groove
• Fracture shaft of humerus
• Prolonged torniquet pressure
11. 3. Low– at or below the elbow
• PIN injury– radial tunnel syndrome
fractures (monteggia fracture)
iatrogenic
• superficial radial nerve injury
o fracture
o iatrogenic (venous canulation)
o Laceration
o Blunt trauma
12. Clinical features
• Very high radial injury–
o weak elbow extension
o loss of wrist, finger and thumb extension (wrist drop)
o Sensory loss over the posterior arm, forearm and
posterolateral hand
• High radial injury
o Normal elbow extension
o Loss of wrist, finger and finger extension
o Normal sensation over posterior arm and forearm
o Sensory loss over posterolateral hand
13. • Low radial injury
Posterior interosseus nerve injury
o Normal elbow and wrist extensors
o Weak finger and thumb extensors
o Normal sensation over posterior arm, forearm and
posterolateral hand
Superficial radial nerve injury
o Normal extensors
o Sensory loss over posterolateral hand
o Normal sensation over posterior arm and forearm
14. Wartenberg syndrome
• Compression of
superficial branch of
radial nerve between
ECRL and
brachioradialis
• Numbness over
posterior aspect of
thumb
15. Radial tunnel syndrome
• About 5 cm space
• Dorsally– capsule of the
radiocapitellar joint
• Volarly– brachioradialis
• Laterally– ECRB and ECRL
• Medially– biceps tendon and
brachialis
• PIN nerve compressed
• C/F– loss of finger and thumb
extension, weak wrist
extension
16. Median nerve
• Roots from the lateral ( C5, C6,
C7) and medial ( C8, T1) cords
unite to form the median nerve
• In the axilla– no branches
• In the arm– descends along the
lateral side of the 3rd part of the
axillary artery and brachial
artery
• Near the insertion of the
coracobrachialis, it crosses in
front of the brachial artery from
lateral to medial side
17. In the cubital fossa
• Lies medial to the
brachial artery
• Covered by bicipital
aponeurosis
18. In the forearm
• Enters forearm between
the two heads of
pronator teres
• Passes beneath the arch
of flexor digitorum
superficialis
• Runs between flexor
digitorum superficialis
and flexor digitorum
profundus
19. Branches in the forearm
1. Anterior interosseus nerve
• Arises between the two heads of pronator teres
• Descends between and deep to FPL and FDP
along with anterior interosseus artery
• Supplies
i. Flexor policis longus
ii. FDP (lateral half i.e. Index and middle finger)
iii. Pronator quadratus
21. In the wrist
• 5 cm proximal to the
flexor retinaculum it
emerges from behind the
lateral edge of FDS
• Lies between the tendons
of FDS and FCR
• Passes laterally from
beneath the tendon of
Palmaris Longus deep to
the retinaculum
22. Branches in the hand
1. Lateral terminal branch
• Supplies thenar muscles
• 1st lumbrical
• 3 proper palmer digital
nerves
2. Medial terminal branch
• Supplies 2nd lumbrical
• 2 common palmer digital
nerves
27. Classification
• High: above the origin of Anterior
interosseous nerve (proximal to elbow)
• Low: injury in distal 3rd of forearm
• Carpel tunnel syndrome
28. High median nerve injury
• Injury proximal to elbow
• Due to forearm fractures or elbow dislocations
• Stab and gun shot wounds
• Paralysis of all the muscles supplied by it in
forearm and hand
29. Low median nerve injury
• Injury in distal 3rd of forearm
• Cuts in front of wrist and carpel bone
dislocations
• Spare forearm muscle
• paralysis of muscles of hand, thenar intrinsic
muscle paralysis
• Thumb abduction and opposition weak
• Sensation lost over radial 3 and half fingers
30. • Anesthesia over median nerve distribution in
hand
• Thenar eminence wasted, thumb abduction
and oppositions of fingers are weak
• Sensations lost over three and half of radial
fingers
31. Examinations
• Flexor pollicis longus:
patient is asked to flex
the terminal phalynx of
the thumb while his/her
base of thumb is held
32. • Flexor digitorium
superficialis and
profundus: (oscher’s
clasping test) patienr is
asked to clasp both the
hands where index
finger of affected side
fails to flex.
33. • Flexor carpi radialis: hand deviates to ulnar
side when flexed against resistance
• Muscles of thenar eminance: abductor pollicis
brevis (pen test): pen is kept level higher than
thumb and pts is asked to touch tip of pen
40. Ulnar nerve
• Composed of fibers from C8
and T1 coming from medial
cord of brachial plexus
• Above the axilla: It courses
with the axillary artery and
vein and lies deep to
pectoralis minor
• In the axilla, it crosses
medial to brachial artery and
lies deep to the pectoralis
major
41. In the arm
• At the level of distal attachment
of coracobrachialis to the
humerus (about 10 cm proximal
to the medial epicondyle), ulnar
nerve pierces the medial
intermuscular septum to enter
the posterior compartment of
the arm.
• Here it lies on the anterior
border of the medial head of the
triceps
• Then it passes through the
ligament of Struthers and then
behind the medial epicondyle
through cubital tunnel
42.
43. In the forearm
• As the nerve exits the cubital tunnel, it courses
between the two heads of flexor carpi ulnaris
and enters the anterior compartment of the
forearm.
• Shortly after exiting the cubital tunnel, ulnar
nerve gives off motor branches to the flexor
carpi ulnaris
• It then lies on the anterior surface of the flexor
digitorum profundus
• At about 5 cm distal to the medial epicondyle,
ulnar nerve gives off branches to the ulnar
aspect of FDP (providing innervation to long
flexors of ring and small fingers)
• In the middle of the forearm, at about 12 cm
distal to the medial epicondyle, ulnar nerve
becomes superficial and meets with the ulnar
artery as it travels towards the wrist
44. In the wrist
• Ulnar nerve and artery lie in a canal
formed by the pisiform bone
medially and the hook of hamate
laterally (guyon’s canal)
• In this region the nerve divides into
1. The superficial sensory branch–
distal palm, 5th and half of 4th digit
2. The deep motor branch–
hypothenar muscles, adductor
pollicis,3rd and 4th lumbricals,
palmar digital branches to medial
one and half fingers
45.
46. Ulnar nerve injury
At the level of elbow
Motor loss
• FCU and medial half of FDP paralyzed
• Profundus tendon to the ring and little fingers will be
functionless
• Terminal phalanges to these fingers fail to flex properly
• Flexion of wrist will result in abduction due to paralysis of
FCU
• Small muscles of hand will be paralyzed except the muscles
of thenar eminence and first two lumbricals
• Adductor pollicis longus is paralyzed-- adduction of thumb
not possible
47. • Metacarpophalyngeal joints
become hyperextended due
to paralysis of lumbrical and
interosseus muscles
• IP joints are flexed (claw
hand)
• Dorsum of hand shows
hollowing due to wasting of
the dorsal interosseus
muscles
48. Sensory loss
• Loss of skin sensation over anterior and
posterior surfaces of medial 3rd of the hand
and medial one and half fingers
49. At the level of wrist
Motor loss
• Small muscles of the hand paralyzed
• Claw hand more obvious (as FDP not
paralyzed)
• Marked flexion of terminal phalanges occur
50. Sensory loss
• Sensory loss over the palmer surface of medial
3rd of the hand and medial one and half finger
51. Froment’s sign
• Weakness of adductor
pollicis: pts asked to grip
sheet of paper forcefully
between thumb and index
finger while examiner try
to pull it away, powerful
flexion of thumb
interphalyngeal joint of
affected side signal
weakness in adductor
pollicis.
• FPL flexes thumb
52. Card test and Egawa test
• Inability to hold a card or paper
between the fingers due to loss
of adduction by the palmer
interossei
Egawa test
• With the palm placed flat on the
table, the patient is asked to
move the middle finger sideways
• This is a test for the dorsal
interossei of middle finger
53. Guyons tunnel syndrome
• Entrapment of ulnar
nerve in pisohammate
tunnel(guyon’s canal)
• Seen in long distance
cyclist, lean with
pisiform pressing on
handlebars
54. Cubital tunnel syndrome(ulnar
neuronitis)
• Compression or
entrapment of nerve in
medial epicondylar
tunnel(cubital tunnel)
• Esp in severe valgus
deformity of elbow or
prolong pressure of
elbow on anesthetised
patient
55. Autonomous sensory zones
• These are the regions where single nerve supply distinct
and non-overlapping areas of skin
• Radial nerve: 1st dorsal web space of hand (Anatomical
snuff box)
• Median nerve: Distal phalanx (tip) of index finger (2nd
finger)
– Other: Tip of thumb
• Ulnar nerve: Distal phalanx (tip) of little finger (5th finger)
57. Classifications
• Seddon’s classifications:
1. Neurapraxia:
• reversible physiological nerve conduction block
• Spontaneous recovery after few days
2. Axonotmesis:
• loss of conduction but the nerve is in continuity and nerve
tubes are intact
• Recovery may occur but may take several months
3. Neurotmesis:
• Severe damage to the nerve
• May occur without actually dividing the nerve
• Spontaneous recovery unlikely
58. • Sunderland classifications:
1. 1st degree: Transient ischemia and
neuroprexia, Reversible
2. 2nd degree: Seddon’s axonotmesis,
regeneration can lead to complete or near
complete recovery without intervention.
3. 3rd degree: worse, endoneurium disrupted
but perineural sheath intact, fibrosis limit the
recovery
59. • 4th degree: only epineurium is intact, nerve
trunk still in continuity but internal damage is
severe , recovery unlikely
• 5th degree: nerve divided and will have to be
repaired
60. Diagnosis
Clinical examination
• Tinel sign– gentle percussion by finger or
hammer over the course of injured nerve
produces tingling sensation in the distribution
of the injured nerve
• A positive sign is presumptive evidence that
regenerating axonal sprouts that have not
obtained complete myelinization are
progressing along the endoneural tube
62. Treatment of nerve injuries
.General considerations
• Maintain ABC
• Evalutate nerve injury
• Open wound should be cleansed and debrided
• Immediate primary repair of nerve done if
o Wound is clean and sharply incised
o Patient is stable
o Adequate personnel and equipments
• Delayed primary repair– 7-18 days
• >18 mths—loss of motor end plates and muscle fibrosis
• Release of compression
63. • When closed fractures are complicated by peripheral
nerve injuries, reinnervation awaited and early surgical
exploration avoided.
• If nerve deficit follows manipulation or casting of a
closed fracture, early exploration of nerve done.
64. Techniques
• Neurolysis
o External neurolysis– nerve is freed from enveloping scar
o Internal neurolysis– nerve sheath dissected longitudinally to
relieve the pressure from the fibrous tissue within the nerve
• Epineural neurorrhaphy
• Perineural (fascicular ) neurorraphy
individual fasciculi sutured within the nerve trunk
Suture used– 8-0 or 9-0 monofilament nylon for epineural
suturing and 9-0 or 10-0 for perineural suturing
65.
66.
67. Closing nerve gaps
• Mobilization of nerve
• Positioning of joint—to relax the nerve
• Transposition
• Bone resection
• Nerve grafts
68. Interfascicular nerve graft
If nerve gap is more than 10 cm
Donor nerves
• Sural
• Saphenous
• Lateral cutaneous nerve of thigh
• Lateral and medial cutaneous nerve of the forearm
• Posterior cutaneous nerve of the forearm
• Superficial nerve of the radial nerve
• Dorsal branch of the ulnar
• Intercostal nerves
69. Post- operative care
• Upper limb immobilised in plaster slab (minimum of 4
wks)
• Wound dressed after 7-10 days