Radial Nerve is very important topic for first year MBBS Students and as well as for day today clinical practice. This slide gives you full course & relations with clear diagrams as well as applied anatomy with clinical Co-relation.
Radial Nerve is very important topic for first year MBBS Students and as well as for day today clinical practice. This slide gives you full course & relations with clear diagrams as well as applied anatomy with clinical Co-relation.
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
With the pandemic overclouding the whole world it has effected every strato of people including the Orthopaedic groups. This is to highlight the impact of COVID 19 on the orthopaedic in general.
Conservative management in 3 and 4 part proximal humerus fractureBipulBorthakur
Proximal humerus fracture is common in both young as well as elderly people with most of the elderly patients unable to undergo operative management. This study is to see the aspect of conservative management in proximal humerus fracture.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
1. ANATOMY OF RADIAL
NERVE AND WRIST DROP
DR. BIPUL BORTHAKUR
PROFESSOR,
DEPARTMENT OF ORTHOPAEDICS
SILCHAR MEDICAL COLLEGE AND HOSPITAL
2. ANATOMY OF RADIAL NERVE
o The radial nerve isacontinuation of posterior cord of
brachial plexus.
o It isthe largestnerve of the brachial plexus.
o It suppliesthe posterior(extensor)
compartment of upperlimb.
o It carriesfibres from all the roots(C5,C6,C7, C8,andTl)of
brachialplexus .
4. COURSE IN AXILLA
• The radial nerveliesposterior to the third partof the
axillaryartery andanteriorto the musclesforming the
posterior wall of the axilla.
• Hereit givesoff the following three branches:
1. Posterior cutaneousnerveofarm
2. Nerveto the long headoftriceps.
3. Nerveto the medial headoftriceps
5. COURSEINTHEARM
• Radialnerveentersthe arm
at the lower border of
the teresmajor.
• It passesbetweenthe long
and medialheadof tricepsto
enter the lower triangular
space,through whichit
reachesthe spiralgroove
alongwith profundabrachii
artery.
8. • At the lower 3rd of the
humerus, it piercesthe
lateral intermuscular
septumto enter anterior
part of the arm.
• It lies between the
brachialismedially and
brachioradialis and extensor
carpiradialislongus laterally.
9. COURSE IN FOREARM
• Toenter the forearm, the
radial nerve moves
anteriorly over the lateral
epicondyle of the
humerus.
• In the cubital fossa, it
terminate into two
branches:
1. Surperficial branch
(sensory).
2. Deep branch (motor) also
called as posterior
interosseous nerve
10.
11. COURSE OF SUPERFICIAL RADIAL NERVE
It descends deep to brachioradialis ,emerges proximal
to radial styloid process and passes over the roof of
anatomical snuff-box.
It supplies skin over the lateral part of the dorsum of
hand and dorsal surfaces of lateral 3⅟₂ digits
(excluding the nail beds).
12.
13. RADIAL NERVE PALSY
Clinical findings
The patient loses the ability to extend the wrist, fingers and thumb movements that are
essential for function grasp.
In addition patient loses the grip strength because he cannot stabilize the wrist during
power grip.
A high radial nerve palsy is defined as an injury proximal to the elbow. Wrist, fingers(MCP
joint) and thumb extension and abduction are lost and results in WRIST DROP.
14. RADIAL NERVE PALSY
Clinical findings
Low radial nerve palsy is defined as injury to the PIN, occurs distally to the elbow. Wrist
extension is preserved because the more proximally innervated ECRL remains intact.
If the PIN is injured proximally ECU function may be lost resulting in radial deviation and
wrist extension.
If the injury to the PIN is more distal ECU function is preserved and wrist extension remains
balanced.
15. ETIOLOGY
Humeral fractures – during
fracture(Holstein-Lewis) or during surgery
Iatrogenic – upper limb surgery
Direct trauma
Prolonged application of tourniquet
Crutch palsy
Intramuscular injections
Compression neuropathies-
Saturday night paralysis
17. Lesionsof the radialnerve
Lesions Motor deficits Sensory loss
Lesionat theaxilla Tricepsweakness Lateral dorsum of the handand
injured by the pressure
of the upper end of
crutch (crutch palsy),
by adislocation atthe
shoulder joint,
Brachioradialis weakness
Extensor weaknessof the
wrist - "wristdrop”
wrist
Dorsumof the thumb
Proximal dorsum of fingers
2 and 3
Byafracture of
the proximal humerus.
Lesionat thespiral Tricepsis spared! Lateral dorsum of the handand
wrist
Dorsumof the thumb
Proximal dorsum of fingers
2 and 3
groove of humerus: Brachioradialis weakness
Midshaft fracture of
humerus.
Wrongly placed
Extensor weaknessof the
wrist - "wrist drop”
intramuscular injection.
Saturday night paralysis.
Lesionat the radial
tunnel
(humeroradialjoint)
Extensor weaknessof the
wrist - "wrist drop" -maybe
mild
Lateral dorsum of the handand
wrist
Dorsumof the thumb
Proximal dorsum of fingers 2 &3.
18. TREATMENT OF RADIAL PALSY
Non-operative:-
Full passive range of motion in all joints of the wrist and
hand and prevention of contractures, including that of the
thumb-index web.
Splints
Wrist drop can be treated successfully by splints
19. INTERNAL SPLINT
Burkhalter proposed early transfer of PT-ECRB to
restore wrist extension as an adjunct to nerve repair.
It restores the power grip quickly and effectively since
wrist extension is restored
Advantages are:
It works as a substitute during nerve regrowth and largely
eliminates an external splint
Subsequently the transfer aids the newly innervated and
weak wrist extensor
It continues to act as a substitute in case nerve regeneration
is poor or absent
20. INDICATIONS FOR SURGERY
In a sharp injury exploration is indicated for diagnostic,
therapeutic and prognostic purposes
In avulsion , blasting injures –to identification of the
nerve injury and making the ends of the nerve with
sutures for later repair.
When a nerve deficit follows blunt or closed trauma,
and no clinical or electrical evidence of regeneration
has occurred after an appropriate time, exploration of
the nerve is indicated.
22. TENDON TRANSFER FOR
RADIAL NERVE PALSY
There are three main goals:
Restoration of finger(MCP joint) extension
Restoration of thumb extension
Restoration of wrist extension
Three main patterns of tendon transfer
Jones transfer
Brand’s transfer
Boyes transfer
23. TENDON TRANSFER FOR
RADIAL NERVE PALSY
Restoration of wrist extension
Most accepted method is PT to ECRB transfer.
If recovery of the radial nerve is not expected, the transfer should be done in end-to-end
fashion.
If the radial nerve has been repaired and ECRB re-innervation is expected in the future, the
transfer should be done in a end-to-side fashion.
24.
25. TENDON TRANSFER FOR
RADIAL NERVE PALSY
Restoration of thumb extension
The Palmaris longus or ring finger FDS are most often used.
When the ring FDS is used, it can be split and inserted into the both EPL and the EIP,
allowing concomitant thumb and index finger extension.
When the PL is used as a motor, the EPL is usually rerouted volarly to meet the PL in a direct
line of pull, which results in abduction of the thumb as well as IPJ extension.
26.
27. TENDON TRANSFER FOR
RADIAL NERVE PALSY
Restoration of finger MCP joint extension
Can be done transferring the FCR, FCU or FDS tendon.
Jones transfer: In 1900s Jones popularized the use of FCU to restore MCP extension
Jones transfer sacrifices the only remaining ulnar-sided wrist motor which results in radial
deviation of the wrist along with the loss of ulnar deviation with wrist flexion which is an
important wrist motion essential for activities like hammering and throwing.
28.
29. POST-OPERATIVE CARE
AND REHABILITATION
Regardless of the procedure performed the patient should be placed in an above elbow splint or
cast.
The elbow should be flexed at 90 degree with forearm pronated and wrist extended at 30
degree.
This takes tension off the PT to ECRB transfer.
The thumb should be abducted and extended and MCP joints of the fingers extended to take
tension off the transfers to the EDC and the EIP.
The IP joints of the fingers should be left free.
30. POST-OPERATIVE CARE
AND REHABILITATION
The post-operative splint can be changed at one to two weeks for wound check and to refit the
splint.
At 4 weeks post-operatively a thermoplastic splint should be fabricated.
During the first 4 weeks of the surgery it is important to maintain the ROM of the shoulder and
the IP joints of the fingers.
At 4 weeks mobilization begins and exercises will focus on mobilization of single joints at a time
while keeping tension off the transfer.
Mobilization begins with active ROM and advance to gentle passive ROM.