Tuberculosis is a chronic infectious disease caused by the bacterium Mycobacterium tuberculosis, which primarily affects the lungs. It spreads through the air when people who are sick with TB expel bacteria into the air, for example by coughing. Predisposing factors include poverty, malnutrition, and conditions that weaken the immune system. There are two main types - primary TB occurs in those never exposed before and may spread to lymph nodes, while secondary TB occurs from reactivation of a previous infection after immunity is compromised. Diagnosis involves tests such as chest x-rays, sputum smear and culture, and Mantoux skin test. Treatment consists of a multi-drug regimen administered under direct observation to prevent drug resistance,