The document discusses various topics related to pulmonary physiology including:
1) Lung volumes and capacities are measured using spirometry, with the sum of two volumes being measured.
2) Boyle's law states that in a constant temperature system, gas pressure is inversely proportional to volume.
3) At sea level, the partial pressure of oxygen in the atmosphere is approximately 160 mm Hg.
Bronchiectasis refers to the congenital/acquired irreversible airway dilation that involves the bronchi/bronchioles in either a focal or a diffuse manner.
It is a pulmonary disease related to chronic infections in the background of inability of respiratory mucosa to clear the infections and impaired ciliary function.
It is chronic disease with high morbidity and mortality
Acute exacerbation of bronchial asthma dr. mukesh bhatt afpa_rdmc_06_20180422Parthiv Mehta
Exacerbation of Bronchial Asthma can be simple and easy to difficult and life threatening. This presentation is a point of view of a Family Physician with practical aspects to understand
Bronchiectasis refers to the congenital/acquired irreversible airway dilation that involves the bronchi/bronchioles in either a focal or a diffuse manner.
It is a pulmonary disease related to chronic infections in the background of inability of respiratory mucosa to clear the infections and impaired ciliary function.
It is chronic disease with high morbidity and mortality
Acute exacerbation of bronchial asthma dr. mukesh bhatt afpa_rdmc_06_20180422Parthiv Mehta
Exacerbation of Bronchial Asthma can be simple and easy to difficult and life threatening. This presentation is a point of view of a Family Physician with practical aspects to understand
1. In the above diagram C arteriol blood which carries oxyginated bl.pdfanilart346
1. In the above diagram C arteriol blood which carries oxyginated blood from left vetricle to
body parts, The partial pressure PO2 is 80-100 and partial pressure of PCO2 is 40.
2.E represents veinus blood, which carries deoxyginated blood from tissues to heart. The partial
pressure PO2 is 40-50 and partial pressure of CO2 PCO2 is 45.
3. Hyberbaric setting are used in medical treatment in which ambient pressure is greater than sea
level. It is used in hyberbaric oxygen theraphy.
4. This helps to increase the higher of concentration of oxygen in tissues. But higher pressure of
xygen may cause toxicity. It causes temporary blurred vision.
B. Differece in Partial pressure gradient between alveolar air and pulmonary capillary blood, and
systemic capillary blood and surrounding tissue.
Ability of oxygen to bind haemoglibin is called affinity for oxygen. Fetal haemoglobin has more
greater affinity to oxygen.
Solution
1. In the above diagram C arteriol blood which carries oxyginated blood from left vetricle to
body parts, The partial pressure PO2 is 80-100 and partial pressure of PCO2 is 40.
2.E represents veinus blood, which carries deoxyginated blood from tissues to heart. The partial
pressure PO2 is 40-50 and partial pressure of CO2 PCO2 is 45.
3. Hyberbaric setting are used in medical treatment in which ambient pressure is greater than sea
level. It is used in hyberbaric oxygen theraphy.
4. This helps to increase the higher of concentration of oxygen in tissues. But higher pressure of
xygen may cause toxicity. It causes temporary blurred vision.
B. Differece in Partial pressure gradient between alveolar air and pulmonary capillary blood, and
systemic capillary blood and surrounding tissue.
Ability of oxygen to bind haemoglibin is called affinity for oxygen. Fetal haemoglobin has more
greater affinity to oxygen..
This is the introduction to airway management for Advanced EMTs though some medics might find it useful too. Focuses mainly on supraglottic and periglottic airway devices as well as basic anatomy , physiology, etc. Talks about apniec defusion too.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
47. Alveolar pressure may exceed arterial pressure in all of the following conditions EXCEPT A. Hemorrhage B. Patients on positive pressure ventilation C. Normal individual playing a wind instrument D. Healthy woman during normal inspiration
48. Alveolar pressure of oxygen at sea level is approximately A. 21 mmHg B. 45 mmHg C. 40 mmHg D. 100 mmHg
49.
50. Please select the correct relationship Top of the lung Bottom of the lung A. Ventilation Higher Lower B. Blood Flow Higher Lower C. V/Q Higher Lower D. PO 2 Lower Higher E. PCO 2 Higher Lower
51. Select the FALSE statement regarding the diffusion capacity for oxygen A. It is directly proportional to the number of pulmonary capillaries opened at a given time B. It is inversely proportional to the thickness of the alveolar-capillary membrane C. It is increased during the exercise D. It is unaffected by removal of part of the lung
52. Transfer of CO into the blood is “diffusion limited” because A. Partial pressure of CO rises very high in the blood as it flows along the pulmonary capillary B. CO chemically combines with Hb at a very high rate, keeping the pressure gradient at a high level C. CO transports is not dependent on thickness of alveolar-capillary membrane D. CO transport is limited by the amount of blood flowing through pulmonary capillaries
53. Which of the following has the greatest effect on the ability of blood to transport oxygen A. Capacity of the blood to dissolve oxygen B. pH of plasma C. CO 2 content of red blood cells D. Amount of hemoglobin in the blood E. Temperature of the blood
54. What is the difference in the arterial oxygen content of an individual who is breathing room air versus breathing 100%oxygen A. Zero B. About 1.8ml C. About 5.4ml D. 10.2ml
55. The affinity of hemoglobin for oxygen is decreased by all of the following EXCEPT A. Increased hydrogen ion concentration B. Increased temperature C. Exercise D. Increased 2,3 DPG E. Decreased temperature
56. How is CO2 transported ? A A small portion of CO 2 (5%) is transported in the dissolved state to the lungs. B The dissolved CO 2 reacts with water to form carbonic acid. C Formation of carbamino compounds with plasma proteins and hemoglobin. D All of the above E None of the above
57. BOYLES law states A. In a constant temperature system, pressure is inversely proportional to volume. B. In a constant volume system, pressure is directly proportional to the temperature. C. In a constant temperature system, pressure is directly proportional to volume. D. In a constant volume system, pressure is inversely proportional to the temperature.
58. On the the summit of Mt. Everest, where the barometric pressure is about 247mmHg, the partial pressure of inspired oxygen is about? A. 1 mm Hg B. 8 mm Hg C. 42 mm Hg D. 100 mm Hg
59. The volume of air that could enter the lung after a normal inspiration is the A. Tidal volume B. Expiratory reserve volume C. Residual volume D. Inspiratory reserve volume E. Dead space volume
60. During inspiration, as the diaphragm contracts, the pressure in the pleural space becomes? A. Equal to zero B. More positive C. More negative D. Equal to the pressure in the alveoli E. Equal to the pressure in the atmosphere
61. When a pneumothorax is induced, the chest wall__________ and the lungs____ A. Collapses in, Expands out B. Expands out, Collapses in C. Both Remain where they were D. Both collapse in
62.
63. During the effort independent region of a forced expiration, flow is limited by? A. Contraction of expiratory muscles B. Inertia of chest wall C. Transmural pressure becomes zero D. Increased airway compliance E. Transmural pressure becomes positive
64. A patient is being artificially ventilated during surgery at a rate of 20 breaths/min and a tidal volume of 250ml/breath. Assuming a normal anatomical dead space of 150ml, the alveolar ventilation in this patient is A. 1000ml/min B. 2000ml/min C. 3000ml/min D. 4000ml/min E. 5000ml/min
65. In which of the following conditions is alveolar PO 2 increased and alveolar PCO 2 decreased A.Breathing air with low PO 2 B.Increased alveolar ventilation and unchanged metabolism C.Decreased alveolar ventilation and unchanged metabolism D.Increased metabolism and unchanged alveolar ventilation E.Proportional increase in metabolism and alveolar ventilation
66. In the upright position, ventilation per unit lung volume is greater at the base of the lung than at the apex because the base of the lung A. Has more negative intrapleural pressure than the apex at the start of inspiration B. Is less expanded than the the apex C. Has lower compliance than the apex D. Has more intrapulmonary-intrapleural pressure difference than the apex at the start of inspiration
67. BOYLES law states A. In a constant temperature system, pressure is inversely proportional to volume. B. In a constant volume system, pressure is directly proportional to the temperature. C. In a constant temperature system, pressure is directly proportional to volume. D. In a constant volume system, pressure is inversely proportional to the temperature.