The document discusses the history and development of pulmonary artery catheters. It describes how Dr. Swan and Dr. Ganz invented the balloon-tipped catheter and how it allows direct measurement of pressures in the heart and lungs. The document outlines the proper insertion technique and provides normal values for pressures measured in different areas of the heart and lungs. It also discusses indications, contraindications, and complications of pulmonary artery catheter use.
Pulmonary artery catheterisation, Cardiac surgeries, Non cardiac surgeries, LVEDD and PA pressure relationship, Technique and complications of PA placement
Pulmonary artery catheterisation, Cardiac surgeries, Non cardiac surgeries, LVEDD and PA pressure relationship, Technique and complications of PA placement
comprehensive presentation on 2D echo use in ICu set up. helpful in finding causes of shock and also in monitoring of fluid status in critically ill patients.
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Comprehensive presentation on intra arterial blood pressure with a good insight into the the basic physics and brief look into the risks and complications.
comprehensive presentation on 2D echo use in ICu set up. helpful in finding causes of shock and also in monitoring of fluid status in critically ill patients.
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Comprehensive presentation on intra arterial blood pressure with a good insight into the the basic physics and brief look into the risks and complications.
central venous pressure and intra-arterial blood pressure monitoring. invasiv...prateek gupta
central venous pressure and intra-arterial blood pressure monitoring. various sites for cvp and Ibp insertion. working principle for cvp and ibp. indication and complication. various waveform of cvp and ibp
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. History
Introduction of Right Heart Catheterization- 1929 by
Forsmann.
Urinary catheter into his own cubital vein and into his
right heart.
Cournand and Richards developed catheters that can
be advanced upto pulmonary artery.
3. 1970 - Dr Swan noticed how easy it was for
a sailboat to move even in the slightest
breeze.
Dr Swan then invented the balloon tipped
catheter.
Dr Ganz was working on thermo dilution
methods to calculate cardiac output.
So the pulmonary artery catheter was
named Swan Ganz.
7. Indications
• Diagnostic:
– Differentiation among causes of shock.
– Differentiation between mechanisms of
pulmonary edema.
– Evaluation of pulmonary hypertension.
– Diagnosis of pericardial tamponade.
– Unexplained dyspnea.
8. • Therapeutic:
– Management of perioperative patients with
unstable cardiac status
– Management of complicated myocardial
infarction.
– Management of patients following cardiac
surgery/high risk surgery
– Assess response to pulmonary
hypertension specific therapy.
9. Contraindications
• Absolute:
o Infection at insertion site.
o Tricuspid or pulmonary stenosis.
o Right atrial or ventricular mass.
• Relative:
Coagulopathy.
Thrombocytopenia.
Electrolyte disturbances (K/Mg/Na/Ca)
Severe Pulmonary HTN.
Arrhythmia, LBBB.
Newly inserted pacemaker.
10.
11.
12.
13. Preparation
1. Patient has to be monitored with continuous
ECG throughout the procedure.
2. Check balloon integrity by inflating with 1.5ml
of air.
3. Check lumens patency by flushing with saline.
4. Cover catheter with sterile sleeve provided.
14. Technique
1. Local infiltration done.
2. Aseptic precautions must be employed.
3. Cannulate vein with Seldinger technique.
4. Place sheath.
5. Pass catheter through sheath with tip curved
towards the heart(11 o’clock).
15. 6. Once tip of catheter passed through introducer
sheath --- inflate balloon at level of right
atrium~20cm.
7. Continous waveform analysis through right
ventricle pulmonary artery wedge position.
8.After acquiring wedge pressure deflate
balloon.
16. • Important:
– When advancing catheter- always inflate tip.
– When withdrawing catheter- always deflate.
– Once in pulmonary artery - NEVER INFLATE
AGAINST RESISTANCE - RISK OF PULMONARY
ARTERY RUPTURE
17.
18.
19. • Elevated RA pressure:
– Diseases of RV(infarction/ cardiomyopathy)
– Pulmonary hypertension
– Pulmonic stenosis
– Left to right shunts
– Pericardial diseases
– LV systolic failure
– Hypervolemia
20. • Abnormal RA waveforms:
– Tall v waves: Tricuspid Regurgitation
– Giant/ cannon a waves:
• Ventricular tachycardia
• Ventricular pacing
• Complete heart block
• Tricuspid stenosis
– Loss of a waves:
• Atrial fibrillation/ Atrial flutter
25. • Pulmonary artery:
– The risk of arrhythmias is greatest while
catheter tip is in RV
Thus, catheter should be advanced from RV to
without delay.
• Main components of PA tracing:
– Systolic and Diastolic pressure
– Dichrotic notch(due to closure of pulmonic
valve)
26. • Normal pulmonary artery pressures:
– Systolic -15-25mmHg
– Diastolic - 8-15 mmHg
– Mean - 10-22mmHg
27.
28. • Increase in mean pulmonary pressure:
– Acute:
• Venous Thromboembolism
• Hypoxemia induced Pulmonary Vasoconstriction
– Acute on Chronic:
• Hypoxemia induced pulm VC in patient with chronic
cardiopulmonary disease
– Chronic:
• Pulmonary hypertension
29. Pulmonary arterial occlusion pressure
•Final position of the catheter must be such that
PCOP tracing is obtained whenever 1.5ml volume of
balloon is insufflated.
Overwedged- If < 1ml of air is injected and PAOP
is seen.
–needs to be withdrawn
Too proximal- If maximal inflation fails to result in
PCOP tracing or after 2-3 seconds delay.
-advance the PAC.
30. • PCWP/PAOP interprets Left atrial pressures
LVEDP
– Best measured in
• Supine position
• At end of expiration
• Zone 3 (most dependent region)
– Normal PCWP- 6-15 mmHg ; Mean :9mmHg
31.
32. Lung zones by West and colleagues.
PAC wedged in lung zone 3 for accurate measure of
pulmonary venous (Pv) or left atrial (LA) pressure.
34. • Decreased PCWP:
– Hypovolemia
– Obstructive shock due to large pulmonary
embolus
• Abnormal waveforms
– Large a waves:
• MS
• LV systolic /diastolic function
• LV volume overload
• MI
– Large v waves - MR
36. • Related to insertion of PAC:
– Arrhythmias (most common- Ventricular/
– Misplacement
– Knotting
– Myocardial/valve/vessel rupture
• Related to maintenance and use of PAC:
– Pulmonary artery perforation
– Thromboembolism
– Infection
42. Bolus Thermodilution
Injecting a solution that is colder
than blood through the right atrial
port of the catheter and
measuring the temperature
change distally with a built in
thermistor.
The area under the time-
thermodilution curve is used to
calculate the cardiac output.
TIME
Conc.
Area under curve = CO
46. PAC Volumetric Thermo-dilution Catheter
Thermal Filament
• 10 cm in length
• 14-25 cm from tip
• Rests between RA & RV
• Should be free floating
and avoid endocardial
surface
• Should NOT be in PA
Balloon Inflation
• Appropriate inflation
volume is 1.25-1.5 cc
Proximal Injectate Port
• 26 cm from tip
• Transduce RV waveform &
withdraw ~ 5cm
• Should be located in RA
• Should NOT be in RV
47. Continues Cardiac Output Monitoring
Thermal filament in RA to provide
heat in specific, repetitive on-off
sequences, sensed by distal
thermistor.
These “pulses” of energy replace the
traditional fluid bolus.
Gives CCO value with a 30 sec
update.
No need for calibration, bolus
injection.
Correlates well with ‘gold standard’
bolus thermodilution.
48. ICO vs. CCO
GOLD Standard for CO
Area underneath washout curve
equates to CO
Suffers from inexperienced users
Misses information between
measurements
Time consuming
Still thermodilution technique
Continuous monitoring
Not time consuming
Remove inaccuracies associated
with Bolus technique
Continuous information to help
treat patient early
Cuts down on nursing/doctors time
CCO
ICO
49. TYPES OF PAC
Paceport – capable of providing cardiac pacing.
Continuous Cardiac Output-- produces
thermodilution curve to determine cardiac output.
Mixed venous O2 – can determine venous oxygen
Saturation.
Heparin coated.
50. CONS
PAC use in 5735 patients in first 24 hrs intensive care associated with
increased mortality, hospital stay and cost (Connors etal,1996)
Three trials including 3468 patients showed no effect on mortality but
higher incidence of adverse effects (Harvey etal (PACMAN), 2005; The
ESCAPE Trial, 2005; Sandham etal, 2003)
51. …….Cardiac surgery patients
National database analysis by Chiang et al., among 2,063,337
patients undergoing cardiac surgery (coronary and/or valve surgery)
in the US between 2000 and 2010, those who underwent pulmonary
artery catheterization were found to have a significantly higher
operative mortality.
Database analysis by Brovman et al. found that among 116,333
patients undergoing coronary artery bypass graft (CABG) or valve
replacement surgeries in the US between 2010 and 2014, the
presence of PAC did not result in significant decreases in the odds of
cardiac arrest or death
52. Trend in pulmonary artery catheter use between 1993 and
2004 according to pre-identified diagnoses (Wiener RS, Welch HG
Trends in the use of the pulmonary artery catheter in the United States, 1993–2004. JAMA
2007;298:423–9)
53.
54. PROS
Pulmonary artery catheter use is associated with reduced mortality in
severely injured patients: a National Trauma Data Bank analysis of
53,312 patients. Friese RS, Shafi S, Gentilello LM - Crit. Care Med. - Jun
2006; 34(6); 1597-601
Multi-center cohort analysis by Sotomi et al. in a population with
acute decompensated heart failure demonstrated that use of PAC
resulted in a decrease in all-cause mortality
In mixed medical and surgical population with PAC use, APACHE scores
– <25 - Increased mortality
– >31 - Significant benefit (Chittock etal, 2004)
55. Sarkar M, Umbarkar S. Pulmonary artery catheter – Dilemma is still on?. Ann Card
Anaesth 2021;24:1-3
56.
57. Summary
PAC itself is not a therapeutic intervention.
PAC can help to guide the therapy.
High doses of ionotropes or vasoconstrictors are best
managed (choose & titrate)using all the data from a PAC
(SVR; PVR; SVO2).