This document compares Oracle Primavera P6 and Microsoft EPM for project portfolio management software. It summarizes the experiences of two biotech companies, one using Primavera and one using EPM. Both systems provided schedule management and cost tracking. Primavera had advantages for customization and speed while EPM was easier to use but slower. Project prioritization was important, with both companies ranking projects based on business drivers, though Primavera calculated scores while EPM used pairwise comparisons. In conclusion, Primavera P6 is preferred for its robust capabilities over the less mature EPM, though company standards could favor Microsoft.