This document compares project portfolio management tools Microsoft EPM and Primavera P6 v7. It summarizes the experiences of two biotech companies, one using Primavera and one using Microsoft EPM. Key reasons for using project portfolio management included schedule management, cost management, and project selection assistance. The document discusses how each company handled transition from manual Excel tracking, system architecture differences, scheduling, cost tracking, project prioritization, and notes. It provides examples and screenshots from both Primavera and Microsoft EPM.