Streptomycin is an antibiotic produced by fermentation of Streptococcus griseus. It was discovered in 1944 and is effective against both gram-positive and gram-negative bacteria, especially Mycobacterium tuberculosis. The fermentation process involves three phases where S. griseus grows on a medium containing soy meal and glucose to produce streptomycin over 4-10 days. After filtration and purification steps including adsorption, elution and crystallization, the streptomycin is recovered and used clinically to treat tuberculosis and other bacterial infections.