prodrug in biopharmaceutical chemistry and drug design

1. PRODRUGS
Syllabus
Introduction
Different strategy with examples

3. 1. Carrier linked prodrug
- Compounds that contain active drugs linked to carrier group that can be removed
Enzymatically such as ester which is hydrolysed to active carboxylic acid containing drugs.
- The Carrier group is non toxic , inert, inactive when detached from drug.
- It should be remove easily.
-These link is temporary
-Example: Cholarmphenicol

4. 2. Bioprecursor Prodrug

5. Different strategies of design of prodrug.
1. Prodrug to improve membrane permiability

6. 2. Example

7. 3. Example
Torjane Horse approach for transport protein
Levodopa given in ester
form to
Cross BBB
Ester form

8. 2. Prodrug to prolong drug activity

9. 2. Example

10. 3. Prodrug masking side effects & drug toxicity

11. 2. Example

12. 4. Prodrug lowers water solubility

13. 5. Prodrug improve water solubility

14. 2. Example

15. 6. Prodrug used in targeting the drug therapy

16. 7. Prodrug increase the chemical
stability

17. 8. Prodrug activated by external influence of
sleeping agents