This document discusses hard and soft drugs. Hard drugs are biologically active and non-metabolizable, while soft drugs are designed to have predictable and controllable metabolism into nontoxic products after their therapeutic effect. Soft drugs provide advantages like avoiding toxic metabolites and increasing the therapeutic index. They are divided into categories like soft analogs, activated soft compounds, and those based on active or inactive metabolite approaches. The document contrasts soft drugs with prodrugs and provides examples to illustrate different types of soft drugs.