This document discusses tobacco control interventions as cost-effective "best buys" for preventing noncommunicable diseases. It outlines the tobacco epidemic and impact on health and economies. The WHO Framework Convention on Tobacco Control and MPOWER strategies are presented as evidence-based mechanisms for implementing demand reduction measures like tax increases and protection from smoke, as well as supply measures. Case studies show progress in implementing strong warning labels, advertising bans, and tax increases in countries like Iran, Jordan, and Egypt. Tobacco control is estimated to avert over 5 million deaths at relatively low cost.