This document provides operational guidelines for implementing Positive Health, Dignity and Prevention programs. It was developed jointly by the Global Network of People Living with HIV and UNAIDS based on extensive consultations. The guidelines aim to shift HIV responses to a more holistic and rights-based approach that empowers people living with HIV and meets their clinical, social and economic needs. The document outlines 8 components that programs should address, and provides a 3-step process for assessment, operationalization and planning of Positive Health, Dignity and Prevention actions at the national level to achieve global HIV targets.