This document provides an overview of the HIV response and opportunities for involvement by young people living with HIV (YPLHIV). It defines the HIV response as encompassing all efforts to prevent HIV infections, ensure human rights of those living with and affected by HIV, and provide access to services and support. It outlines the various actors in the HIV response, including networks of people living with and affected by HIV, community organizations, international NGOs, governments, UN agencies, donors, and researchers. The document emphasizes that the HIV response occurs at community, local, national, regional and global levels, providing YPLHIV with a wide range of potential involvement opportunities.