The point of inflection is the point on a curve where the concavity changes, such that the curve transitions from concave down to concave up or vice versa. Mathematically, it is the point where the second derivative equals zero or changes sign, indicating a switch between increasing and decreasing slope. To find the point of inflection, take the second derivative of a function and set it equal to zero to solve for the x-value where the concavity changes.