This document summarizes the case of a 3 day old male neonate born at 41 weeks gestation via lower uterine cesarean section with meconium aspiration and respiratory distress since birth. On examination, the baby was tachypneic with generalized convulsions, bulged chest, and weight below the 10th percentile. Investigations revealed perinatal asphyxia, hypoxic ischemic encephalopathy, and meconium aspiration. The diagnosis was term small for gestational age neonate with perinatal asphyxia, hypoxic ischemic encephalopathy, and meconium aspiration. Management included supportive care, antibiotics, anticonvulsants, and follow up.
Apnea (AP-nee-ah) is a pause in breathing that lasts 20 seconds or longer for full-term infants. If a pause in breathing lasts less than 20 seconds and makes your baby's heart beat more slowly (bradycardia) or if he turns pale or bluish (cyanotic), it can also be called apnea.
A Case of Primigravida with 36 weeks of pregnancy with IUD with obstructed la...Faisal Abdullah
This case was presented on weekly seminar of Department of Gynaecology and Obstetrics ( Unit 1) of Faridpur Medical College Hospital, in October 2019, by Intern Doctor Dr. Faisal Abdullah.
Apnea (AP-nee-ah) is a pause in breathing that lasts 20 seconds or longer for full-term infants. If a pause in breathing lasts less than 20 seconds and makes your baby's heart beat more slowly (bradycardia) or if he turns pale or bluish (cyanotic), it can also be called apnea.
A Case of Primigravida with 36 weeks of pregnancy with IUD with obstructed la...Faisal Abdullah
This case was presented on weekly seminar of Department of Gynaecology and Obstetrics ( Unit 1) of Faridpur Medical College Hospital, in October 2019, by Intern Doctor Dr. Faisal Abdullah.
Case report about Obstetric and Gynecological (obgyn) The patient came to the OPD complaining of vaginal bleeding for 5 months. After her menopause state.
Case Study Report on PIH and Severe Pre eclampsiaRashmi Regmi
it is a case study report on PIH and Severe Pre eclampsia
I did when I was posted on Kist Medical TEaching Hospital for Midwifery Practicum
Prepared by:
Rashmi Regmi
B Sc Nursing
Manmohan Memorial Institute Of health Sciences
Normal newborn care, by Dr Amal Khalil, Dean of Nursing college, Port said University, Port said. Presented in the NICU nursing workshop, organized by Nursing syndicate in Suez canal & Sinai in cooperation with Port said university college of nursing & Port said neonatology society, December,2014 Port said
A 32-year-old woman, gravida 5,Para1 ,Living 1 And abortion 3 presented to emergency department for bleeding per vagina at 33 weeks and 3 days,have GDM that is controlled by diet and previous LCSC 7 years ago. She is not in labor.
Case report about Obstetric and Gynecological (obgyn) The patient came to the OPD complaining of vaginal bleeding for 5 months. After her menopause state.
Case Study Report on PIH and Severe Pre eclampsiaRashmi Regmi
it is a case study report on PIH and Severe Pre eclampsia
I did when I was posted on Kist Medical TEaching Hospital for Midwifery Practicum
Prepared by:
Rashmi Regmi
B Sc Nursing
Manmohan Memorial Institute Of health Sciences
Normal newborn care, by Dr Amal Khalil, Dean of Nursing college, Port said University, Port said. Presented in the NICU nursing workshop, organized by Nursing syndicate in Suez canal & Sinai in cooperation with Port said university college of nursing & Port said neonatology society, December,2014 Port said
A 32-year-old woman, gravida 5,Para1 ,Living 1 And abortion 3 presented to emergency department for bleeding per vagina at 33 weeks and 3 days,have GDM that is controlled by diet and previous LCSC 7 years ago. She is not in labor.
A case presentation and discussion of ALL presented in a Tertiary Care Hospital ER. Includes presenting complaints, work-up, diagnosis and relevant case discussion.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Particulars of the patient
Name: Baby of Tamanna.
Age: 3 days.
Sex: Male.
Address: Laxmipur, Noakhali.
Date of Admission: 26.10.2015.
Date of Examination: 26.10.2015.
3. Chief Complaints
Born after 9 days of expected date of
delivery.
Passage of meconium in utero.
Delayed cry after birth.
Respiratory distress since birth.
4. History of present illness
According to the statement of father, baby was
delivered by LUCS 9 days after the expected date of
delivery with average birth weight. Baby cried about
10 minutes after birth following resuscitation. Baby
had h/o passage of meconium in utero and
developed respiratory distress since birth. He also
had h/o convulsion from 2nd day of life. With these
complaints, the baby was admitted in a local
hospital and then referred to Dhaka Shishu Hospital
for further evaluation and better management.
5. Birth History
Antenatal : Mother, Tamanna, a 20 years old
lady, gravida – 1st , para – 1, was on regular
antenatal check up and was normotensive &
nondiabetic. There was no history of fever
with rash or taking any offending drug during
her pregnancy period. She was immunized
against tetanus and her blood group is B
positive.
6. Birth History (cont..)
Postnatal : Baby cried about 10 minutes after
birth following N-P & O-P suction and physical
stimulation.
Natal : Baby was delivered by LUCS at 41 weeks
of gestational age at 10.00 PM on 24.10.2015 at
hospital due to maternal oligohydramnios. Liquor
was meconium stained.
7. Family History
He is the 1st issue of his non-consanguineous
parents.
Socio-economic History
He came from a low socio-economic family.
Feeding History
Baby was kept nothing per oral.
8. Physical Examination
o Baby was pink with O₂, acyanotic, anicteric,
having generalized convulsion.
o Weight : 2230 gm ( below 10th centile ).
o Length : 47 cm ( just below 10th centile ).
o OFC : 33 cm ( just below 10th centile ).
o Temperature : 99° F.
o CRT ˂ 3 seconds.
o SPO₂ (Pulse oximeter) : 98% with O₂ (5L/min).
9. Cont..
o Fontanelle : Normal, not bulged.
o Face : No dysmorphysm.
o Eye : Pupil size was normal, light reflex was
present.
o Nose : Normal.
o Ear : Normal.
o Oral cavity : Normal.
o Neck : Normal.
10. Cont..
o Respiratory rate : 68/min.
o Chest was bulged, chest movement was
symmetrical on both side, subcostal indrawing
was present.
o Air entry was good and symmetrical in both
side, no added sound.
o Heart rate : 100/min.
o Apex beat was palpable in left 4th intercostal
space just medial to the mid clavicular line, 1st
and 2nd heart sound was audible in all 4 areas,
no murmur.
11. Cont..
o Abdomen : Soft, not distended.
o Umbillicus : Meconium stained.
o Liver : Not palpable.
o Spleen : Not palpable.
o Kidneys : Not ballotable.
o Bowel sound : Present.
o Genitalia : Both testes are in scrotum.
12. Cont..
o Anal opening was patent.
o Spine : Normal.
o Hip joints (both) : Normal.
o Movement of all joints : Normal.
o Muscle tone : Normal.
o Primitive reflexes : Good.
o No visible congenital anomaly.
13. New Ballard Score
Neuromuscular Maturity
Neuromuscular Maturity
Sign
Score
Posture Flexion of hip and limb 3
Square window (Wrist) 30° 3
Arm recoil ˂90˚ 4
Popliteal angle 100° 3
Scarf sign Elbow do not pass midline 4
Heal to ear Up to 90˚ 3
14. New Ballard Score
Physical Maturity
Physical Maturity Sign Score
Skin Superficial peeling 2
Lanugo Mostly bald 4
Planter surface Creases over entire sole 4
Breast Full areola, 5 mm bud 4
Ear Formed and firm, instant
recoil
3
Genitals (male) Testes pendulous, deep
rugae
4
16. Salient feature
Baby of Tamanna, 3 days old male neonate, 1st issue
of his parents, was delivered by LUCS at 41 weeks of
gestational age due to maternal oligohydramnios
and cried about 10 minutes after birth with h/o
meconium aspiration. He developed respiratory
distress since birth and had h/o convulsion. Baby
was tachypnoeic, having generalized convulsion
with bulged chest with good air entry. His primitive
reflexes were normal with good muscle tone. His
weight falls below 10th centile.
17. Provisional Diagnosis
Term (41 weeks) with Small for Gestational
Age with Perinatal Asphyxia with Hypoxic
Ischemic Encephalopathy (ll) with Meconium
Aspiration Syndrome.
18. Investigations
Complete Blood Count :
• Hb%: 16.6 gm/dl
• WBC: Total count: 8,300/cumm
Differential count:
o Neutrophil: 60%
o Lymphocyte: 36%
o Monocyte: 02%
o Eosinophil: 02%
o Basophil : 00%
19. Cont..
o RBC: Macrocytic with normochromic.
o WBC: Shows as distribution.
o Platelet: Normal.
• Platelet : 1,79,000/cumm
• PBF:
23. Final Diagnosis
Term (41 weeks) with Small for Gestational Age
with Perinatal Asphyxia with Hypoxic Ischemic
Encephalopathy (ll) with Meconium Aspiration.
24. Management
A.Counseling.
B.Supportive:
Maintenance of temperature.
Airway clearance by O-P & N-P suction.
Maintenance of breathing by O₂ inhalation @
5L/min.
Maintenance of circulation.
Maintenance of hydration and nutrition : Inf.
10% dextrose in 0.225% NaCl ( 100ml/kg ).
25. Cont..
Inj. Ceftazidime 100 mg/kg/day in 2 divided
doses.
Inj. Amikacin 15 mg/kg/day in 2 divided
doses.
Inj. Phenobarbitone 20mg/kg IV stat.
Inj. Phenobarbitone 5mg/kg/day in 2 divided
doses (maintenance dose).
Inf. 10% Dextrose 2ml/kg IV bolus.
Inj. KT 1ml in each 100 ml IV fluid.
Inj. Dobutamine 5µgm/kg/min.
C.Follow up.