Meem, a 1 year 5 month old girl, presented with a 1 month history of fever and 20 days of cough. On examination, she appeared toxic and had reduced breathing sounds and dullness on percussion of the left lung. Chest X-ray and ultrasound showed a large left-sided pleural effusion. Thoracostomy drained purulent fluid and antibiotics were given. The final diagnosis was left-sided empyema thoracis likely due to pneumonia. Follow up found the patient afebrile with normal breath sounds.
Pneumonia - Community Acquired Pneumonia (CAP)Arshia Nozari
An overview to Community Acquired Pneumonia; It's Pathophysiology, Etiology, Epidemiology, Diagnosis and Treatment according to Harrison's Internal Medicine, 20th Edition (2018).
Pneumonia - Community Acquired Pneumonia (CAP)Arshia Nozari
An overview to Community Acquired Pneumonia; It's Pathophysiology, Etiology, Epidemiology, Diagnosis and Treatment according to Harrison's Internal Medicine, 20th Edition (2018).
Bronchiolitis is a common disease for children. After watching this slide you will be able to know about bronchiolitis. To get health services to visit our Facebook pages.
https://www.facebook.com/medicalstudyandhealthtips/
Pneumonia is an infection of the lower respiratory tract that involves the airways and parenchyma with consolidation of the alveolar spaces
Banadir Hospital Pediatric Departments
Bronchiolitis is a common disease for children. After watching this slide you will be able to know about bronchiolitis. To get health services to visit our Facebook pages.
https://www.facebook.com/medicalstudyandhealthtips/
Pneumonia is an infection of the lower respiratory tract that involves the airways and parenchyma with consolidation of the alveolar spaces
Banadir Hospital Pediatric Departments
Bilateral Pulmonary Hydatid Cysts with Ruptured & Infected Hydatid Cyst of Le...Dharmendra Joshi
Bilateral Pulmonary Hydatid Cysts with Ruptured & Infected Hydatid Cyst of Left Lung - A Case Presentation
Operations:
First Operation:
VATS Enucleation of Hydatid Cyst of Lung (Right side)
Second Operation:
VATS followed by minimally invasive open Enucleation and Capitonnage of Hydatid Cyst of Lung (Left side)
Thyroid Swelling: A practical guide on writing and presenting a clinical caseMuskaan Khosla
Every book tells us how to examine and what to examine in a clinical case. But, no book tells us exactly how to write a sheet and how to word the case. Here is a practical example ! Hope it helps!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
2. Particulars of the patient
Name: Meem
Age: 1 year 5 months
Sex: Female
Address: Manikgonj
Date of Admission: 18.06.2015
Date of Examination: 20.06.2015
5. History of present illness
According to the statement of mother,
Meem was reasonably well 1 month back.
Then she developed fever which was
initially low grade, intermittent in nature
and later became high grade, continued in
nature and relieved by taking antipyretics.
She also developed dry cough for last 20
days. She had no h/o contact with TB
patient.
6. History of present illness(cont..)
With these complaints, she was admitted in a
local hospital and treated with injectable
antibiotics. As her condition did not improve
significantly, she was referred to Dhaka Shishu
Hospital for further evaluation and better
management.
8. Birth History:
She was delivered normally at term without
any complication.
Feeding History:
She is on family diet.
Immunization History:
She is immunized as per EPI schedule.
9. Familly History
She is the 2nd issue of her non-consanguineous
parents. Her other family members are healthy.
Socio-economic History
She comes from a low socio-economic
background. She lives in a tin-shed house, drinks
tube-well water and uses sanitary latrine.
10. Treatment History
After admission, she was treated by oral and
injectable medications, but could not mention
the name.
Developmental History
She is developmentaly age appropriate.
11. General Examination :
Appearance: Ill looking, toxic
Anaemia: Mildly pale
Jaundice:
Cyanosis:
Clubbing: Absent
Oedema:
Dehydration:
12. Cont..
Skin: BCG mark present
Lymphnode: Not palpable
Signs of meningeal irritation: Absent
Ear:
Nose: Normal
Throat:
15. Systemic Examination
Respiratory system :
Inspection :
Respiratory rate: 32/min
Shape of the chest : Bulged on left side, inter-
costal fullness present on left side
Movement of the chest : Restricted in left side
16. Cont..
Palpation :
Trachea was shifted to the right side.
Chest expansibility was reduced in left side.
Apex beat was palpable in left 4th intercostal
space, medial to the midclavicular line..
Vocal fremitus was absent along the mid-
clavicular, mid-axillary and post-scapular line
of left side, normal in right side.
17. Cont..
Percussion :
Percussion note was dull over left lung field in
mid-clavicular, mid-axillary and post-scapular
line, normal in right lung field.
18. Cont..
Auscultation :
Breath sound and vocal resonance was absent
in left lung along the mid-clavicular, mid-
axillary and post-scapular line, normal in right
lung.
There was no added sound.
19. Cont..
Cardiovascular system :
1st & 2nd heart sounds are audible in all 4
areas.
There is no added sound.
Alimentary system :
No organomegaly.
No ascitis.
Other Systemic examination: No abnormality
20. Salient feature
Meem, 1 year 5 months old immunized girl,
was admitted with the complaints of fever for
1 month which was initially low grade,
intermittent in nature and later became high
grade, continued in nature and dry cough for
last 20 days. She had no h/o contact with TB
patient. Meem was toxic, febrile, mildly pale
and having BCG mark.
21. Cont..
Chest movement and expansibility was
reduced in left side. Mediastinum was shifted
to the right side, percussion note was dull on
left side. Vocal fremitus, vocal resonance and
breath sound was absent in left side and
normal in right side. There is no
lymphadenopathy or organomegaly.
27. Cont..
Chest X-ray: Homogenous opacity seen at left
lung field, heart and trachea are pushed
towards right, findings suggestive of pleural
effusion.
28. Cont..
Mantoux test : 00 mm
USG of chest : Thick pleural fluid with
consolidation seen at left side of hemithorax.
At left costophrenic angle – 294 ml,
mid part – 257 ml,
upper part – 237 ml.
29. Cont..
Pleural fluid study: Smear showed many
polymorphs, lymphocytes and histiocytes in
an eosiophillic proteinaceous background.
Total leukocyte count – Plenty
Biochemistry : Protein : 5.8 g/dl
Sugar : 53 mg/dl
Gram staining – Bacteria not found
Ziehl-Neelsen staining – AFB not found
Culture & sensitivity : No growth of bacteria.
31. Management
• Counseling.
• Supportive treatment:
Maintenance of nutrition and hydration.
Propped up position.
Antipyretics.
• Tube thoracostomy was done on 22.06.2015.
Chest tube was kept in situ for 2 days.
• Parenteral antibiotics: Inj. Meropenem
(20mg/kg/dose 8 hourly).
32.
33. Follow up on 24.06.2015
Patient was afebrile.
Respiratory rate : 24/min.
Shape of the chest was normal and movement
was bilaterally symmetrical. Trachea was
centrally placed.
Percussion note was resonant, vocal fremitus
and vocal resonance were normal and breath
sound was vesicular in both lungs.