It is a novel drug dosage form in herbal drugs.I have made it, because it is a part of my project work. I hope you will find helpful and knowledgeable. Thank you.

1. -Mayank pandey

2.  The term "phyto" means plant and "some" means
cell-like. Phytosomes are little cell like structures.
 This is advanced form of herbal formulations
which contains the bioactive phytoconstituents of
herb extracts surround and bound by a lipid.
 Most of bioactive constituents are water soluble
compounds like flavonoids, glycosides.
 Because of their water soluble property and
lipophilic outer layer it shows better absorption
and produce better bioavailability.

3.  Phytosome is a complex between natural product and
natural phospholipid.
 The Phytosome complex is obtained by reaction of
suitable amount of phospholipid and the substrate in
appropriate solvent such as glycerol.
 The main phospholipid-substrate interaction is due to
formation of hydrogen bonds between polar head of
phospholipid and polar functionalities of substrate.
 When treated with water, they assume a micelle shape,
forming structures which resembles liposomes.

5.  Enhanced absorption of herbal constituent.
 As the absorption of active constituents is improved,
its dose requirement is also reduced.
 Phosphotidylcholine acts as hepatoprotective, giving
synergistic effect.
 It shows better stability profile.
 It assures proper delivery of drugs to the respective
tissues.

6.  When administered orally or topically they limit their
bioavailability.
 Phytoconstituents is quickly eliminated from
phytosome.
 Stability problem.

7.  Phospholipids: phosphatidylcholine, egg
phosphatidylcholine, dipalmityl phosphatidylcholine,
phosphatidylcholine, phosphatidylethanolamine
 Aprotic solvent: Dioxane, acetone , methylene
chloride
 Non-solvent: n-hexane
 Alcohol: Ethanol, methanol

10. There are three types of methods of phytosomal
preparation. They are as follows:-
1. Antisolvent Precipitation Technique
2. Rotary Evaporation Technique
3. Solvent Evaporation Technique

11.  Spectroscopic evaluation:- It is employed in order to
confirm the formation of complex as well as to study
interactions
 Determination of drug content:- Determined by UV
spectrophotometer
 In-vitro and In-vivo evaluation:- This can be done
according to therapeutic activity measurement
parameters of biologically active phytoconstituents
present in Phytosome

12.  Improve bioavailability
 Improve efficacy
 Absorption enhancement
 Antioxidant properties
 Hepato protective
 Transdermal application
 Cancer treatment

13. Constituents Biological activity
Curcumin Anticancer and antioxidants
Ginkgo biloba Antidiabetic and cardioprotective
Ginsenosides Immunomodulator and
nutraceuticals
Hawthorn Cardioprotective
Naringenin Anticancer and anti
inflammmatory