Marie Curie was born in Poland as Maria Sklodowska, discovered radioactivity, and was the first person to win two Nobel Prizes. She discovered that the activity of uranium depended only on its quantity and that radiation came from within atoms.
Albert Einstein postulated that light travels in individual photons in 1905, and published his special theory of relativity that same year and general theory of relativity in 1916. He is renowned for his contributions to early 20th century physics.
Niels Bohr researched the structure of atoms, first postulating that electrons travel around the nucleus and predicted splitting of uranium atoms.
This power point slides presents how the electrons and protons were discovered together with the personalities involved with this scientific breakthrough.
Lesson 3 Atomos, Aristotle and Alchemy (Chemistry Before Modern History)Simple ABbieC
Lesson 3 Atomos, Aristotle and Alchemy (Chemistry Before Modern History)
CONTENT:
How the idea of the atom, along with the idea of the elements evolved
CONTENT STANDARD
At the end of the lesson, you will have to describe:
1. how the concept of the atom evolved from Ancient Greek to the present; and
2. how the concept of the element evolved from Ancient Greek to the present
LEARNING COMPETENCIES
At the end of the lesson, you will have to:
1. describe the ideas of the Ancient Greeks on the atom (S11/12PS-IIIa-b-5)
2. describe the ideas of the Ancient Greeks on the elements (2 hours) (S11/12PS-IIIa-b-6)
3. describe the contributions of the alchemists to the science of chemistry (S11/12PS-IIIb-7)
The discovery of the atomic world and the constituents of matterRochelle Forrester
The discovery of the atomic world and the constituents of matter was written to investigate the order of discovery of the sub atomic particles. The discovery of these particles took place in a necessary and inevitable order with charged particles, such as electrons and protons, discovered before neutrons, and particles in the outer regions of the atom such as electrons being discovered before protons and neutrons in the atomic nucleus, and with quarks which exist within protons and neutrons being the last discovery. The order of discovery is from those particles closest to us to those further from us in the sense of being deeper in the atom. The order of discovery and the social and cultural consequences of the discoveries took place in a necessary and inevitable order and is consistent with the conclusions reached in my book How Change Happens: A Theory of Philosophy of History, Social Change and Cultural Evolution.
Alchemy, the art of fiction and science intertwined. Or is it? Alchemy is about as old as man himself. See for yourself what mysteries lie awaiting your gaze. Gloucester, Virginia Links and News. GVLN. Visit us for all kinds of incredible works.
This power point slides presents how the electrons and protons were discovered together with the personalities involved with this scientific breakthrough.
Lesson 3 Atomos, Aristotle and Alchemy (Chemistry Before Modern History)Simple ABbieC
Lesson 3 Atomos, Aristotle and Alchemy (Chemistry Before Modern History)
CONTENT:
How the idea of the atom, along with the idea of the elements evolved
CONTENT STANDARD
At the end of the lesson, you will have to describe:
1. how the concept of the atom evolved from Ancient Greek to the present; and
2. how the concept of the element evolved from Ancient Greek to the present
LEARNING COMPETENCIES
At the end of the lesson, you will have to:
1. describe the ideas of the Ancient Greeks on the atom (S11/12PS-IIIa-b-5)
2. describe the ideas of the Ancient Greeks on the elements (2 hours) (S11/12PS-IIIa-b-6)
3. describe the contributions of the alchemists to the science of chemistry (S11/12PS-IIIb-7)
The discovery of the atomic world and the constituents of matterRochelle Forrester
The discovery of the atomic world and the constituents of matter was written to investigate the order of discovery of the sub atomic particles. The discovery of these particles took place in a necessary and inevitable order with charged particles, such as electrons and protons, discovered before neutrons, and particles in the outer regions of the atom such as electrons being discovered before protons and neutrons in the atomic nucleus, and with quarks which exist within protons and neutrons being the last discovery. The order of discovery is from those particles closest to us to those further from us in the sense of being deeper in the atom. The order of discovery and the social and cultural consequences of the discoveries took place in a necessary and inevitable order and is consistent with the conclusions reached in my book How Change Happens: A Theory of Philosophy of History, Social Change and Cultural Evolution.
Alchemy, the art of fiction and science intertwined. Or is it? Alchemy is about as old as man himself. See for yourself what mysteries lie awaiting your gaze. Gloucester, Virginia Links and News. GVLN. Visit us for all kinds of incredible works.
The Evolution of Atomic Theory and The Models of the AtomMichaelDeniega2
This is a carefully crafted presentation about the progress of the atomic theory showcasing different atomic model introduced by famous scientists. This is one of the important concepts of discussion in Physical Science 11
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
3. Who was it?
I was born in1766 Eaglesfield,
Cumberland, England
I wrote, y first scientific paper called:
extraordinary Facts relating to the Vision
of Colors. This was the first paper ever
to discover color blindness.
I made research on heat conduction, gas
expansion by heat, properties of light etc.
He told that atoms can neither be
created nor destroyed.
5. Who was it?
I was born in South Dakota, 1901
I made vital contributions to atomic
bomb
I also invented cyclotron that
accelerated particles to high velocity
without high voltage, used to make
new elements
I have also developed e/m ratio of
electron
7. Who was it?
I came to know that the activity of
uranium depended only on the quantity of
uranium present and that radiation did
indeed come from the atom itself rather
than an interaction between molecules.
I was known as Maria Sklodowska and
later it was changed.
I created the history by becoming the
first person to win two Nobel prizes.
9. Who was it?
I was the president of the German Research
Council and also the chairman of the
Commission for Atomic physics, chairman of
the nuclear physics working group.
I was one of the principal scientists leading
research and development in the nuclear
fission, the German nuclear project known as
the “Uranverien”.
I developed the Uncertainty principle of
Quantum Mechanics. I did not cook meth in a
trailer.
11. Who was it?
I carried out experiments regarding the
scattering of light by water and transparent
blocks of ice which explained the
phenomenon.
I also a started a company called Travancore
chemical and Manufacturing Co. ltd. Which
manufactured potassium chlorate.
I am the paternal uncle of Subramanian
Chandrasekhar, who discovered
Chandrasekhar limit.
13. Apart from being a scientist I was also
an architect.
I discovered the microscopic structure in
plants and named it as cell- the building
block of life.
According to my law the tension force in
a spring increases in direct proportion to
the length it is stretched to.
I wrote one of the scientific books ever
written called “Micrographia”.
Who was it?
15. Who was it?
At 2015 I won “BBVA Foundation
Frontiers of Knowledge award” and won
“Pride of Britain awards” at 2016.
I wrote books such as “On the Shoulders
of Giants”, “The universe in a Nutshell”
etc.,
I am the first to set out a theory of
cosmology by a union of the general
theory of relativity and quantum
mechanics.
18. Who was it?
In 1848 I discovered the concept of
being “right handed and left handed”
and found that almost every creature
has molecule in its body
I researched and invented vaccines
for cholera, diphtheria, plague,
tuberculosis etc
20. Who was it?
I was a scientist, mathematician,
physicist, astronomer, engineer,
and weapon-designer
I also invented one of the most
fundamental concepts of physics-
the centre of gravity
22. Who was it?
I have researched about the
structure of the atom
I was the first to postulate that
electrons travel around nucleus of
atom and also predicted splitting
of uranium atoms
24. Who was it?
I had postulated light travels in
individual photons, 1905
I have written special theory of
relativity 1905 & general theory
of relativity 1916
28. Who was it?
I have contributed to early theory of
beta decay and neutrino also
demonstrated nuclear transformation
with neutrons in elements
I have led an experiment that
performed first controlled nuclear
reaction
30. Who was it?
I have discovered alpha
and beta particles in 1898
I have also done
investigations of alpha
scattering in 1910 led to
the discovery of the
nucleus
34. Who was it?
I have made achievements in theory
expansions on Problems of Apollonius
I have also contribution to optical,
the corpuscular theory of light
Reflection
Refraction
Dispersion
40. Who was it?
I have made contribution to
electrochemistry & electromagnetism
I have made the discovery of many
materials that exhibit a weak repulsion
from a magnetic field (diamagnetism) &
plane of polarization of linearly
polarized light
42. Who was it?
I have worked on Kinetic Theory
& Thermodynamics and
contributed to electromagnetism
Discovered electromagnetic
theory of light propagation